DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and Phlpp1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	53/294 - (18%)
Similarity:	103/294 - (35%)	Gaps:	108/294 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   707 SEFNVTASLESDINLVVEGMVTAE-HLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVI 770
            :|.||:.:...::...|..|...: .||..:|::.:           |:.|.|           :
  Rat   680 AELNVSCNALREVPAAVGAMQNLQTFLLDGNFLQSL-----------PAELEN-----------M 722

  Fly   771 AQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTL-- 833
            .||::|.     ||       ||            :|...|.:..:..|...|.:|...:.||
  Rat   723 HQLSYLG-----LS-------FN------------EFTDIPEVLEKLTAVDKLCMAGNCMETLRL 763

  Fly   834 --------ARHMDHEDRVIFKWKTEVAE--QKETANDMRQRN----EALVYN-----------VL 873
                    .:|:|....::.|..|:..:  |..|..|:|...    :|:::|           ::
  Rat   764 QALRRMPHIKHVDLRLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLV 828

  Fly   874 PVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSE-----ETV-------------- 919
            .:::..:|:|       .||:.|...|.:....:||:..:...     |:|
  Rat   829 TLNICGYFLK-------ALYASSNELVQLDVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLD 886

  Fly   920 --NNQGLE------CLRFLNEVISDFDALLELPQ 945
              :||..|      |...|.::::..:.|..||:
  Rat   887 IGHNQICELPARLFCNSSLRKLLAGHNRLARLPE 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		CYCc	860..1071	CDD:214485	22/128 (17%)
		Guanylate_cyc	892..1092	CDD:278633	16/81 (20%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021
		RA_PHLPP1	<424..491	CDD:340760
		PH_PHLPP-like	498..594	CDD:270131
		PLN00113	602..>1109	CDD:215061	53/294 (18%)
		leucine-rich repeat	604..624	CDD:275380
		leucine-rich repeat	625..655	CDD:275380
		leucine-rich repeat	679..701	CDD:275380	5/20 (25%)
		leucine-rich repeat	702..724	CDD:275380	6/43 (14%)
		leucine-rich repeat	725..771	CDD:275380	13/69 (19%)
		leucine-rich repeat	772..795	CDD:275380	4/22 (18%)
		leucine-rich repeat	796..816	CDD:275380	4/19 (21%)
		leucine-rich repeat	817..858	CDD:275380	7/47 (15%)
		leucine-rich repeat	859..881	CDD:275380	2/21 (10%)
		leucine-rich repeat	882..904	CDD:275380	4/21 (19%)
		leucine-rich repeat	905..926	CDD:275380	4/16 (25%)
		leucine-rich repeat	927..950	CDD:275380
		leucine-rich repeat	951..974	CDD:275380
		leucine-rich repeat	977..1000	CDD:275380
		leucine-rich repeat	1001..1024	CDD:275380
		leucine-rich repeat	1067..1112	CDD:275380
		PP2Cc	1151..1403	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900