Protein Alignment Ac3 and adcy3a

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.2
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1145
• Identity: 453/1145 - (39%)
• Similarity: 646/1145 - (56%)
• Gaps: 147/1145 - (12%)

  Fly    33 SDVAGGVGIT-------GGGVVILPQHV--------LNELYHNYSIKQRRSGLKWFVFAAALFNI 82
            ||....||.|       .|..:.||:.:        |..||..|..:||...|...|..||||:.
Zfish    26 SDPGQAVGRTHEVTVRSSGCCLCLPRFMRLTFAPDSLENLYQTYFRRQRHETLLVLVVFAALFDC 90

  Fly    83 WTIGIPWDQSAPTRVINCCMLLA--YLALTALLHIGRRSDKPALRRFHQILLI------------ 133
            :.|            :.|.:|..  .||..|:..:|..:|         :||.
Zfish    91 YII------------VMCTVLYTADKLASVAVASVGLAAD---------VLLYLLCRYGLLPDRV 134

  Fly   134 ---IVPRALWLLSILHFTVYVILQPSFS----PRDLLGWAILLNFLVYVTLPLQL--IFLGLSIG 189
               :||.|||:|.......|:.|  :|:    |.|.:||....:|..::||||:|  |.|..|:.
Zfish   135 TRRLVPYALWVLIAAQIFCYLGL--NFARFHQPSDTVGWQAFFSFSFFLTLPLRLTPIVLITSVS 197

  Fly   190 CITYFICLSLPVGYSHWDSL----LSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSL 250
            |..:.:.|.:.:.....:.:    |..||.||.|:...|..:|::.|:|.:.|.::|||||::||
Zfish   198 CGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYVCAITVGVMSYYMADRKHRKAFLEARQSL 262

  Fly   251 EVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSS----EAFKKIYMSRHENVSILYADIVG 311
            |||:.:||||.:|||||||:||||:|.:|.:|:...:|    :.|..:||.||||||||:|||||
Zfish   263 EVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADIVG 327

  Fly   312 FTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGL 376
            ||.:||:.|||:|||:|||||||||:||.||.||||||||||||||.|.||.|.|||...:.|||
Zfish   328 FTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGL 392

  Fly   377 SMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHIS 441
            :||:||.||::|..:.||||||:|:|.||.|:|||::||:||:|.||.:|||||:.|..||||||
Zfish   393 AMVEAISYVREKTQTDVDMRVGVHSGMVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHIS 457

  Fly   442 DKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKK-INETQAEIAHPNPNG 505
            ..||..|:|||:||...|..|.|.|:..|::||.:...    ..|..|. ||..:..:...|.|.
Zfish   458 QNTLECLHGEFDVEPGNGGDRCEYLKERGIETYLVVLP----KGPVGKNGINGVKLSVTSSNGNS 518

  Fly   506 ----STTDIVSDEDDNDATLDDEELLAQNSVSNG-----HQIGI------AVTADEEEQVKLENF 555
                :||:..........|.:|.|.|....|:..     .::.:      .:.|.|.||    ..
Zfish   519 PLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQENEQ----EL 579

  Fly   556 KQRLKDELVTRDGHENLT-KDTN-IFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYS- 617
            .:.|.:.|:.|:..:.|. |.|| :.|||.:|:||..::|.:|..|.    ||....|:.:|::
Zfish   580 NKLLNEALLERETVQALKGKYTNRLSLRFTDPELETRFSVEKEKQSG----AAFSCSCVVLLFTA 640

  Fly   618 ---YLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIII 679
               .|:.|....:::.:|...|.:.:|.:.|||..|..:.||..|..|...:...:.|...|:..
Zfish   641 VMEALIDPWLVANYVTLAVGEVLLLILTICSLAAIFPRVFPKRLVSFSTWIDHTRWARNTWAMAA 705

  Fly   680 ALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDA 744
            ...:..::::||.             ......|:::||   ..|..:|||           :|..
Zfish   706 IFIVTLADIVDML-------------SCRAPQTSTVES---TAVPPVVTA-----------IRGC 743

  Fly   745 VPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQ---DLYALEDD 806
            ...     |.|.|...||.|||..::.|::|:.|:.|:|.|.......||:...   |||.|...
Zfish   744 AEN-----PKYYSFIAVLALIATTMLVQVSHMVKLTLMLLITVATGAVNIYSWSQTFDLYDLTRF 803

  Fly   807 FEHQ-PIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVY 870
            .|:: .::.::|..|.::.:..::....:||::...|.:|.||.||.||||...:||:.|||||.
Zfish   804 KEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVT 868

  Fly   871 NVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVIS 935
            |:||.|||.||:.:.||. ::||||||.|:||:|||:|||||||:||::||.|:||||||||:||
Zfish   869 NMLPEHVARHFLGSKKRD-EELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIIS 932

  Fly   936 DFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTV-------RNDAPITERWSHLAILVEFALE 993
            |||:||:.|||:.|.||||||||||||||:......       :.:....|||.|||.|.:|||.
Zfish   933 DFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALA 997

  Fly   994 LKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTE 1058
            :|..|.:||.||||:|:|::|:|.|.:.||||||||||:|||||||||||||||||..|.|||.|
Zfish   998 MKVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVE 1062

  Fly  1059 ETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSA 1098
            :...||:.:|:.|::||.:.|||||:|:|::|:|:.:..:
Zfish  1063 DCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGREKQGS 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	175/361 (48%)
		Guanylate_cyc	294..476	CDD:425528	117/181 (65%)
		Guanylate_cyc	892..1092	CDD:425528	126/206 (61%)
adcy3a	XP_009290286.2	None