Protein Alignment Ac3 and adcy6a

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1148
• Identity: 373/1148 - (32%)
• Similarity: 581/1148 - (50%)
• Gaps: 168/1148 - (14%)

  Fly    31 NDSDVAGGVG-ITGGG----VVILPQ------HVLNELYHNYSIKQRRSGLKWF-----VFAAAL 79
            :..|.|.|.| :|...    ||.:.|      ..|..||..|..:..:|.|...     :....:
Zfish   129 SSEDTASGTGSVTAADCWQRVVRVFQSKKFQSRKLERLYQRYFFRLNQSSLTMLMGVLVIVCGVM 193

  Fly    80 FNIWTIGIPWDQSAPTRVINCCMLLAYLAL-TALLHIGRRSDKPALRRFHQILLIIVPRALWLLS 143
            .....|      ..|..|:...:|...:|| .||:.:..|:.      |||       ..:|::|
Zfish   194 LTFHCI------HGPPDVVYASVLSVAMALFLALMVVCNRNG------FHQ-------DYMWMVS 239

  Fly   144 ILHFTVYVILQP----SFSPRDL---LGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPV 201
            .|...|.:|:|.    ..:||..   :.|::...:::|..||:::....||.|.::....|:.
Zfish   240 YLVIGVLIIVQVFGVLMVAPRSASEGIWWSVFFIYIIYTLLPVRMRAAVLSGGVLSAIHLLTT-- 302

  Fly   202 GYSHW-----DSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSA 261
                |     |..|..||:||.::.....:||:..::..|..|::||.|.:..::.::.::.::.
Zfish   303 ----WRINQDDEFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQ 363

  Fly   262 EQERLLLSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLV 325
            :||||||||||:|||::|:.|:.:...: .|.|||:.:|:|||||:|||.|||:::|..:||:||
Zfish   364 QQERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELV 428

  Fly   326 KMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKAN 390
            ..|||||||||:||.:...||||||||||||:||.|:.|.|||..||.||:.|::||..|::...
Zfish   429 MTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTG 493

  Fly   391 SPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVE 455
            ..|:||||||:|.|..|:||.|:|||||:|.||.|||.||:.|||||:||:..||.:|||::|||
Zfish   494 VNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLNGDYEVE 558

  Fly   456 AAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAH-----------------PNP 503
            ..||.:|...|:...::|:.:.        .|::|..:.:|.:|.                 |:.
Zfish   559 PGFGGERNAYLKENSIETFLVL--------GCSQKRKDEKAMMAKMQRTRTNSNEALVPRWVPDR 615

  Fly   504 NGSTT-----------DIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQ 557
            :.|.|           |..|.:|:..|   .|.|..::.|.  ..:|.|:.|...:|::.::.|:
Zfish   616 SFSRTKDSKVFRQMGIDETSSKDNRGA---QEALNPEDEVD--EFLGRAIDARSIDQLRKDHVKK 675

  Fly   558 RLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLP 622
            .|                    |.|:...||:.||...:......:...|||.|.......:|.|
Zfish   676 FL--------------------LTFQTSSLEKKYAKKVDDRFGGYVACTLLVFCFISFIQIVVFP 720

  Fly   623 RSTLHFINIAAPL-VPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFS 686
            . ||..:.|...: :.:|.::.|....|...:.|.....|||:.........|..:...:.:..|
Zfish   721 H-TLVMLGIYISIFIILANILFICAIYSCVKLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFIS 784

  Fly   687 NVIDMFFFVTFVRTEHIVSE----SEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPT 747
            ..::||...|....:.:..:    ||......:.:....|.:|:....:..|         :.|
Zfish   785 AFVNMFSCDTQKLVDCVAKQLNWSSEMVTPCIIHNMSRSVADGLSICPNNTP---------SCP- 839

  Fly   748 ERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSI------------AALHCYFNIFIMQDL 800
                :|.|.|...:|.|:|.:|..|::.:.|:.|:|.|            .||....::|:..:.
Zfish   840 ----FPEYFSYSVLLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTANA 900

  Fly   801 YALEDDFEHQPI-------------ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVA 852
            ....:..:....             :|.:.....:|.|..|||...|:.::...|:.|.||.:..
Zfish   901 LVFNETLQWSNFNTTTEQCTFRVTKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQAT 965

  Fly   853 EQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEE 917
            |:||...:::..|..|::|:||..||.||:...:| :|:||.||...|.|:|||:.|||:||.|.
Zfish   966 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFASISNFSEFYVEL 1029

  Fly   918 TVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWS 982
            ..||:|:||||.|||:|:|||.::...:::.:.||||||||||||||:|      :.....|..|
Zfish  1030 EANNEGVECLRLLNEIIADFDEIISEEKYRQLEKIKTIGSTYMAASGLN------DSTYDKEGRS 1088

  Fly   983 HLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMES 1047
            |:..|.::|:.|:..::.|||.|||:|.:|:|:|.||:.|||||||||.||||||||||||||:|
Zfish  1089 HITALADYAMHLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDS 1153

  Fly  1048 TGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYL 1090
            ||....||||.:...:|...||....||::.|||||::.|::|
Zfish  1154 TGVPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFL 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	48/169 (28%)
		CYCc	256..453	CDD:214485	112/197 (57%)
		Guanylate_cyc	294..476	CDD:278633	103/181 (57%)
		CYCc	860..1071	CDD:214485	106/210 (50%)
		Guanylate_cyc	892..1092	CDD:278633	104/199 (52%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	71/290 (24%)
		Guanylate_cyc	397..570	CDD:306677	101/172 (59%)
		DUF1053	609..696	CDD:310728	22/111 (20%)
		Guanylate_cyc	1004..1197	CDD:306677	104/199 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710