Protein Alignment Ac3 and adcy1b

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_073776301.1
• Gene: adcy1b / 569499
• ZFINID: ZDB-GENE-100805-1
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1150
• Identity: 384/1150 - (33%)
• Similarity: 589/1150 - (51%)
• Gaps: 204/1150 - (17%)

  Fly    78 ALFNIWTIGIPWDQSAPTRVINCCMLLA-YLALTALLHIG-----RRSDKPALRRFHQIL---LI 133
            |||..:.:.:  :|:|..:.::..:||: .|:|..||..|     .:...|.    |.:|   |.
Zfish    36 ALFRRYRLKL--EQTATLKALSVLILLSCSLSLLELLLSGTGLSVAQGSHPV----HSVLFISLF 94

  Fly   134 IVPRALWL----------LSILH-FTVYVILQP------SFSPRDLLGWAILLNFLVYVTLP--- 178
            ||....:|          ||:|. ||..|...|      :..|...:...:||.|:.|..||
Zfish    95 IVTNVQYLQVTQLQQIAHLSLLFGFTFAVPCCPLPQVSRAAGPEQGVWPLLLLTFVAYCLLPVRT 159

  Fly   179 -LQLIFLGLSIGCI-TYFICLSLPVGYSH-WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQK 240
             |.|:| ||.:... |.....:||..... |.||::|.|....|.::     ||....:.|..|:
Zfish   160 GLALLF-GLLLPLAHTLITASALPDNTQRLWRSLVANTLLFTGVNVS-----GLFVRILTERAQR 218

  Fly   241 RAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSIL 305
            :|||:|:..:|.::.:|:::.:|||||:|:||::||::|:||........|.|||:.||:|||||
Zfish   219 KAFLQARNCIEERLRMEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSIL 283

  Fly   306 YADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVL 370
            :|||||||:::|..:||:|||:|||||.:||.||.:....|||||||||||:||....:.|||..
Zfish   284 FADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHC 348

  Fly   371 CVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKA 435
            ||.|||.|:..|..|.:.....::||||:|||.||.|:||.|:||:||:|.||.|||.||:.|..
Zfish   349 CVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLP 413

  Fly   436 GRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITK---------VVKAFASPCAKKI 491
            |:|||:..||..|||::|||...|.:|...|....::|:||..         ::.:...|..|..
Zfish   414 GKVHITRSTLECLNGDYEVEPGNGRERHAFLLKHDIETFFIVPSHRRKIFPGLILSDIKPAKKMK 478

  Fly   492 NET---------------QAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIA 541
            .:|               :|||...|       :::.||.     |...:|........::....
Zfish   479 FKTVCYLLVQLMHCRKMFKAEIPFSN-------VMNCEDG-----DKRRVLRSAPEKLRNRTPTT 531

  Fly   542 VTADEEEQ-VKLENFKQRLKDELVTRDGHENLTKDTN-IFLRFKNPQLEQLYAVYREPY-SSLPL 603
            .:|.:... .::..:..||.:...|    |:.|.|.| :.|.:::.:.|:.|....:.| :...:
Zfish   532 ASAPQSSPGTRVNRYINRLIEARQT----ESDTADLNYLTLMYRDSERERRYHQLNDEYFTGAVV 592

  Fly   604 LAALLVQCIDVLYSYLVLPRSTLHFINIA---APLVPIAMLVVISLAESFSGMLPKFFVDVSKRF 665
            |:.|||..:..|| .|::|:.|:..:.:.   ..||...|.:.|:..:.|.|.|
Zfish   593 LSLLLVVLLGFLY-LLIIPQGTVVLVLLVFCICFLVVCIMYLHITRVQCFPGCL----------- 645

  Fly   666 NDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSES----------EFNVTASLESDIN 720
              ...:|....:.|.|.|                  :.|:::          ..|.|.|:
Zfish   646 --TIQIRTALCVFIVLLI------------------YAVAQACVVGCMPWLWPSNSTRSI----- 685

  Fly   721 LVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSI 785
            ::::.         |:.:.:....:|.....|.......|.|   ::|:..:::.:.|::|||.:
Zfish   686 VIIDA---------AAGLNRTMAELPCAGAQYAFLCCMLGTL---SMALFLRVSWIPKMILLLLL 738

  Fly   786 AALHCYFNIFIMQDL-----YALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIF 845
            ..|  |..|..:...     :||......:|::|        ||:.:.|::..:|.:|.:.|:.|
Zfish   739 LVL--YITILELSGFRRASGWALLSVRGLEPLLS--------LLLFSTAVALHSRQLDLKLRLDF 793

  Fly   846 KWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFM----KNTKRS--HDDLYSQSYAEVGVLF 904
            .|.|:..|:::....::..|:.:::|:||||||:||:    :|..||  |.|||.||||:|||||
Zfish   794 LWATQAEEERDGMEKVKLDNKRILFNLLPVHVAQHFLLSNPRNMVRSSEHQDLYYQSYAQVGVLF 858

  Fly   905 ASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQR 969
            ||:|||:|||.|...||.|:||||.|||:|:|||.|::...::||.||||||||||:|.|:  ..
Zfish   859 ASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGL--VP 921

  Fly   970 TVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDI 1034
            |:...|..:.. :||:.:.:||:|:...|..||.||:|.|||::|||.||:.|||||||:|.|||
Zfish   922 TIGTKAKKSTA-THLSTIADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDI 985

  Fly  1035 WGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQ---- 1095
            |||||||||||:|||..|.|||||:...:|: ..|..:.||.|:||||||::|::|:||:|
Zfish   986 WGNTVNVASRMDSTGVPGKIQVTEDVYRLLQ-NNYDLMCRGNVSVKGKGQMLTYFLEGKAQDPGI 1049

  Fly  1096 --------------------------SSAEPVASGVVVLNGQDSS 1114
                                      .|.....||:.|..|..||
Zfish  1050 RAPHHTGGLERRVHAIARTSSTQTKAGSVSSATSGLAVRVGLSSS 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	151/358 (42%)
		Guanylate_cyc	294..476	CDD:425528	97/181 (54%)
		Guanylate_cyc	892..1092	CDD:425528	114/199 (57%)
adcy1b	XP_073776301.1	None