DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac3 and adcy1b

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_001161822.1 Gene:adcy1b / 569499 ZFINID:ZDB-GENE-100805-1 Length:1114 Species:Danio rerio


Alignment Length:1144 Identity:381/1144 - (33%)
Similarity:585/1144 - (51%) Gaps:199/1144 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 ALFNIWTIGIPWDQSAPTRVINCCMLLA-YLALTALLHIG-----RRSDKPALRRFHQIL---LI 133
            |||..:.:.:  :|:|..:.::..:||: .|:|..||..|     .:...|.    |.:|   |.
Zfish    36 ALFRRYRLKL--EQTATLKALSVLILLSCSLSLLELLLSGTGLSVAQGSHPV----HSVLFISLF 94

  Fly   134 IVPRALWLL-----SILH------FTVYVILQP------SFSPRDLLGWAILLNFLVYVTLP--- 178
            ||....:||     .|.|      ||..|...|      :..|...:...:||.|:.|..||   
Zfish    95 IVTNVQYLLVTQLQQIAHLSLLFGFTFAVPCCPLPQVSRAAGPEQGVWPLLLLTFMAYCLLPVRT 159

  Fly   179 -LQLIFLGLSIGCI-TYFICLSLPVGYSH-WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQK 240
             |.|:| ||.:... |.....:||..... |.||::|.|....|.::     ||....:.|..|:
Zfish   160 GLALLF-GLLLPLAHTLITASTLPDNTQRLWRSLVANTLLFTGVNVS-----GLFVRILTERAQR 218

  Fly   241 RAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSIL 305
            :|||:|:..:|.::.:|:::.:|||||:|:||::||::|:||........|.|||:.||:|||||
Zfish   219 KAFLQARNCIEERLRMEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSIL 283

  Fly   306 YADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVL 370
            :|||||.|:::|..:||:|||:|||||.:||.||.:....|||||||||||:||....:.|||..
Zfish   284 FADIVGSTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHC 348

  Fly   371 CVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKA 435
            ||.|||.|:..|..|.:.....::||||:|||.||.|:||.|:||:||:|.||.|||.||:.|..
Zfish   349 CVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLP 413

  Fly   436 GRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITK---------VVKAFASPCAKKI 491
            |:|||:..||..|||::|||...|.:|...|....::|:||..         ::.:...|..|..
Zfish   414 GKVHITRSTLECLNGDYEVEPGNGRERHAFLLKHDIETFFIVPPHRRKIFPGLILSDIKPAKKMK 478

  Fly   492 NET---------------QAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIA 541
            .:|               :|||...|       :::.||.     |...:|........::...|
Zfish   479 FKTVCYLLVQLMHCRKMFRAEIPFSN-------VMNCEDG-----DKRRVLRSAPEKLRNRTPTA 531

  Fly   542 VTADEEEQ-VKLENFKQRLKDELVTRDGHENLTKDTN-IFLRFKNPQLEQLYAVYREPY-SSLPL 603
            .:|.:... .::..:..||.:...|    |:.|.|.| :.|.:::.:.|:.|....:.| :...:
Zfish   532 ASAPQSSPGTRVNRYINRLIEARQT----ESDTADLNYLTLMYRDSERERRYHQLNDEYFTGAVV 592

  Fly   604 LAALLVQCIDVLYSYLVLPRSTLHFINIA---APLVPIAMLVVISLAESFSGMLPKFFVDVSKRF 665
            |:.|||..:..|| .|::|:.|:..:.:.   ..||...|.:.|:..:.|.|.|           
Zfish   593 LSLLLVVLLGFLY-LLIIPQGTVVLVLLVFCICFLVVCIMYLHITRVQCFPGCL----------- 645

  Fly   666 NDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSES----------EFNVTASLESDIN 720
              ...:|....:.|.|.|                  :.|:::          ..|.|.|:     
Zfish   646 --TIQIRTALCVFIVLLI------------------YAVAQACVVGCMPWLWPSNSTRSI----- 685

  Fly   721 LVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSI 785
            ::::.         |:.:.:....:|.....|.......|.|   ::|:..:::.:.|.:|||.:
Zfish   686 VIIDA---------AAGLNRTMAELPCAGAQYAFLCCMLGTL---SMALFLRVSWIPKTILLLLL 738

  Fly   786 AALHCYFNIFIMQDL-----YALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIF 845
            ..|  |..|..:...     :||......:|::|        ||:.:.|::..:|.:|.:.|:.|
Zfish   739 LVL--YITILELSGFRRASGWALLSVRGLEPLLS--------LLLFSTAVALHSRQLDLKLRLDF 793

  Fly   846 KWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNF 910
            .|.|:..|:::....::..|:.:::|:||||||:||:.:..|:. |||.||||:|||||||:|||
Zfish   794 LWATQAEEERDGMEKVKLDNKRILFNLLPVHVAQHFLLSNPRNM-DLYYQSYAQVGVLFASIPNF 857

  Fly   911 SDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDA 975
            :|||.|...||.|:||||.|||:|:|||.|::...::||.||||||||||:|.|:  ..|:...|
Zfish   858 NDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGL--VPTIGTKA 920

  Fly   976 PITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVN 1040
            ..:.. :||:.:.:||:|:...|..||.||:|.|||::|||.||:.|||||||:|.|||||||||
Zfish   921 KKSTA-THLSTIADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVN 984

  Fly  1041 VASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQ---------- 1095
            |||||:|||..|.|||||:...:|: ..|..:.||.|:||||||::|::|:||:|          
Zfish   985 VASRMDSTGVPGKIQVTEDVYRLLQ-NNYDLMCRGNVSVKGKGQMLTYFLEGKAQDPGIRAPHHT 1048

  Fly  1096 --------------------SSAEPVASGVVVLNGQDSS 1114
                                .|.....||:.|..|..||
Zfish  1049 GGLERRVHAIARTSSTQTKAGSVSSATSGLAVRVGLSSS 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 57/183 (31%)
CYCc 256..453 CDD:214485 105/196 (54%)
Guanylate_cyc 294..476 CDD:278633 96/181 (53%)
CYCc 860..1071 CDD:214485 115/210 (55%)
Guanylate_cyc 892..1092 CDD:278633 114/199 (57%)
adcy1bNP_001161822.1 AC_N <128..270 CDD:292831 44/147 (30%)
CYCc 236..431 CDD:214485 104/194 (54%)
Guanylate_cyc 272..454 CDD:278633 96/181 (53%)
DUF1053 498..585 CDD:283888 20/102 (20%)
CYCc 806..1012 CDD:214485 114/210 (54%)
Guanylate_cyc 839..1035 CDD:278633 114/199 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.710

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