Protein Alignment Ac3 and adcy3b

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_068071803.1
• Gene: adcy3b / 564719
• ZFINID: ZDB-GENE-041014-276
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1075
• Identity: 422/1075 - (39%)
• Similarity: 620/1075 - (57%)
• Gaps: 95/1075 - (8%)

  Fly    54 LNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRR 118
            |.::|..|.::||:..|...:..|||||.:.|.:.....:|.::....:....||...||:|..|
Zfish    49 LEKIYQTYFLRQRQETLLVLIVFAALFNGYVIIMCAVVYSPDKLNTLAVAAGGLASDILLYITSR 113

  Fly   119 SDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPS--FSPRDLLGWAILLNFLVYVTLPLQL 181
            .   .|...| :...:||.|||||.::|...|..|..:  ::..|.:||.....|..::||||.|
Zfish   114 F---RLLPVH-VSACLVPYALWLLIMVHVLCYFSLNFAGFYAAGDTVGWQTFFIFSFFLTLPLPL 174

  Fly   182 --IFLGLSIGCITYFICLSLPVGYSHWD----SLLSNQLAANAVLIATAALIGLLYYFMGEAKQK 240
              |.|.....|..:.:.|...:...:.|    |:|..||.||.:|...|.|:|::.|||.:.|.:
Zfish   175 APIVLLSVFSCCAHTLLLGFTISLRNQDKLQLSVLIRQLVANLMLYFGAMLVGVMSYFMADRKYR 239

  Fly   241 RAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL-----GSSSSEAFKKIYMSRHE 300
            .||||||:||||.:.::|||.:||.||||:||||:|.:|.:.:     ..:.::.|..:||.|||
Zfish   240 TAFLEAKQSLEVSLTLKEQSQQQEELLLSILPKHIADEMLQGMKKGANQKTDAQQFNTMYMYRHE 304

  Fly   301 NVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERP 365
            :||||:|||||||.:||..:.::|||:|||||||||:||.::.||||||||||||||.|.||.|.
Zfish   305 DVSILFADIVGFTQLSSAVTPKELVKVLNELFARFDKLAAQHHQLRIKILGDCYYCICGLPDYRE 369

  Fly   366 DHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKME 430
            |||...:.||||||:||.||::|..:.||||||:|:|.||.|:|||::|||||:|.||.:|||||
Zfish   370 DHAACSIMMGLSMVEAISYVREKTQTGVDMRVGVHSGTVLGGVLGQKRWQFDVWSTDVTVANKME 434

  Fly   431 SSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQ 495
            |.|..||||||..|...|:.|||:|...|.:|.:.|...|:.||.:     ..|...||......
Zfish   435 SGGIPGRVHISQSTKDCLHDEFELEEGNGGERCDYLLEKGIDTYLV-----VMAKETAKTNGVGN 494

  Fly   496 AEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLK 560
            ..:.  |.:||:|.:.:..::::.    :.|...:....|.         |||.:.|      |.
Zfish   495 GTVI--NTSGSSTSVKNTAEESET----QHLQLPSITEEGM---------EEEHLNL------LS 538

  Fly   561 DELVTRDGHENL--TKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPR 623
            ..|:.|:..|.|  .|.:.:.|||::|.||..|:..:|..:.:.......|.........|:.|:
Zfish   539 KTLLEREAEEILEEKKTSALSLRFEDPDLESRYSAEKERQTGVAFSCCCAVLIFTSAMEILIDPQ 603

  Fly   624 STLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNV 688
            ..::::.:|...:.:.:|.:.|||..|..:..:..|..|:..:...:.|...|:.....:..:.|
Zfish   604 LIVNYVTLAIGELLLLILTLCSLAAVFPRVFSRRLVSFSQWIDRTRWARNTWAMAAIFVLTMAEV 668

  Fly   689 IDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYP 753
            .||   ::.|:...::..|...||                         :|.:.:....|...:.
Zfish   669 ADM---LSCVQPPLLLLNSSSGVT-------------------------LESLGNGGCAENPKHY 705

  Fly   754 SYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALED-----DFEHQPII 813
            .|:|   ||.|:|..::.||:|:.|:.|:|.:.......||.....:|.:.|     |:.:. ::
Zfish   706 GYIS---VLSLVATVMLVQLSHVVKLALMLLVTIATGAVNIHSWMYIYDIYDFIRYLDYRYS-VV 766

  Fly   814 STRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVA 878
            .|||..:.::::..|.....|||::.:.|.:|.||.||.:|||...:||..|||||.|:||.|||
Zfish   767 PTRYLLTVMIIIMMLGFYYFARHVERQSRKLFLWKIEVTDQKEKVYEMRTYNEALVTNMLPEHVA 831

  Fly   879 EHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLEL 943
            :||:.:.||. ::||||||.|:||:|||:|||||||:||::||.||||||.|||:|||||:||:.
Zfish   832 KHFLGSKKRD-EELYSQSYDEIGVMFASIPNFSDFYTEESINNGGLECLRILNEIISDFDSLLDR 895

  Fly   944 PQFQDIIKIKTIGSTYMAASGINVQRTVR-------NDAPITERWSHLAILVEFALELKHALQSI 1001
            .:|:.|.||||||||||||||:..:....       .|..:.:||.|.|.|.:|||.:|..|.::
Zfish   896 TEFRHITKIKTIGSTYMAASGVTPESNTNGYADRKIEDQSLLDRWQHFADLADFALAMKVMLGNL 960

  Fly  1002 NEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRL 1066
            |:||||:|:|::|:|.|.:.||||||||||:|||||||||||||||||..|.|||.|:..|||:.
Zfish   961 NKQSFNNFMLRIGLNKGSVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYNILKE 1025

  Fly  1067 FGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPV 1101
            :|:.|::||.:.|||||:|:||:::||     :||
Zfish  1026 YGFRFVRRGPIYVKGKGELLTFFMKGK-----DPV 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	170/345 (49%)
		Guanylate_cyc	294..476	CDD:425528	111/181 (61%)
		Guanylate_cyc	892..1092	CDD:425528	123/206 (60%)
adcy3b	XP_068071803.1	AcyC	95..460	CDD:441717	176/368 (48%)
		Guanylate_cyc	298..460	CDD:425528	104/161 (65%)
		AcyC	627..1048	CDD:441717	187/453 (41%)
		Guanylate_cyc	844..1051	CDD:425528	123/206 (60%)