Protein Alignment Ac3 and adcy5

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001165056.1
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1117
• Identity: 378/1117 - (33%)
• Similarity: 581/1117 - (52%)
• Gaps: 159/1117 - (14%)

  Fly    54 LNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINC----CMLLAYLALTA--- 111
            |..||..|..:..:|.|...:....|.....:|           .:|    |.|...|..||
Zfish   156 LERLYQRYFFRLNQSSLTMLMAVLVLVCAVMLG-----------FHCAGGMCQLTFVLVFTAAIV 209

  Fly   112 ----LLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDL---LGWAILL 169
                |:.:..|:.      |||..:.||   .:||.:|...|.|:......||..   :.|.:..
Zfish   210 LILTLMVVCNRNS------FHQDHMWIV---CYLLILLVLAVQVVGVLFVKPRSASEGIWWTVFF 265

  Fly   170 NFLVYVTLPLQL---IFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLY 231
            ..::|..||:::   :..|:.:..|...|...|    :..|..|..||.:|.::.:.:.::|:..
Zfish   266 IHVIYTLLPVRMRAAVITGIILSAIHVLISWRL----NDMDVFLWKQLVSNVLIFSCSNIVGVCT 326

  Fly   232 YFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE-AFKKIY 295
            ::..|..|::||.|.::.::.::..:.::.:||||||||||:|||::|:.|:.:...: .|.|||
Zfish   327 HYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAKQEDMMFHKIY 391

  Fly   296 MSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGA 360
            :.:|:|||||:|||.|||:::|..:||:||..|||||||||:||.:...||||||||||||:||.
Zfish   392 IQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL 456

  Fly   361 PDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVEL 425
            |:.|.|||..||.||:.|::||..|::.....|:||||||:|.|..|:||.|:|||||:|.||.|
Zfish   457 PEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTL 521

  Fly   426 ANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKK 490
            ||.||:.|||||:||:..||.:|||:::||...|.:|...|:...::||.|.        .|::|
Zfish   522 ANHMEAGGKAGRIHITKATLNYLNGDYDVEPGSGGERNVYLKKHNIETYLIV--------GCSQK 578

  Fly   491 INETQAEIA------------------------HPNPNGSTTDI--VSDEDDNDATLDDEELLAQ 529
            ..|.:|.||                        |.|.|..:.::  :..||..|.. ..|.|..:
Zfish   579 RKEEKAMIAKMNRQRTNSVTHNSTHWTDRPFYNHLNANSVSKEMKRMGFEDPKDKN-TQENLNPE 642

  Fly   530 NSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVY 594
            :.|.  ..:|.|:.|...::::.|:.|:.|                    |.|:.|.||:.|:
Zfish   643 DEVD--EFLGRAIDARSIDRLRSEHVKKFL--------------------LTFREPDLEKKYS-- 683

  Fly   595 REPYSSLPLLAALLVQCIDVLYSY------LVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGM 653
            ::..||.    ...|.|..:::.:      :::|.|.|........||.:.:::.||...|..|.
Zfish   684 KQVDSSF----GAYVACASLVFLFICFIQIIIVPHSGLMVGFYVLCLVVLMVVMFISAIYSCFGF 744

  Fly   654 LPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFF-----FVTFVRTEHIVSESEFNVTA 713
            .|.....:|||.........|..:...:.:..|..|::|.     ..|.:..|..:|.|..|...
Zfish   745 FPIPLQTLSKRIVQSRLNSTLVGVFTIVLVFISAFINIFTCSTDDLKTCLGQEFNISPSNVNACH 809

  Fly   714 SLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTK 778
            :..|.:|..    :.:::.|       ...:.||  ..:|.|.|:..:|.|:|.:|..|::.:.|
Zfish   810 AHFSSLNYT----LWSQNRL-------CNSSSPT--CNFPEYFSSCVLLSLLACSVFLQVSSIGK 861

  Fly   779 ILLLLSIAALHCYFNIFIMQ----------DLYALEDDFEHQP---IISTR----YAASGLLLVA 826
            :.|:|.|..|:    :.||:          ||..:.:......   |:.||    .....::.|.
Zfish   862 LFLMLFIEILY----VLIMEVPEVSLFDNVDLLVMANALAPNNGTCIVDTRVPLKIVTPVVITVF 922

  Fly   827 ALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDD 891
            .|||...|:.::...|:.|.||.:..|:||...:::..|..|::|:||..||.||:...:| :|:
Zfish   923 VLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR-NDE 986

  Fly   892 LYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIG 956
            ||.||...|.|:|||:.|||:||.|...||:|:||||.|||:|:|||.::...||:.:.||||||
Zfish   987 LYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDQFRQLEKIKTIG 1051

  Fly   957 STYMAASGINVQRTVRNDAPITERW-SHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPI 1020
            ||||||||:       ||:...:.. ||:..|.::|:.|...::.|||.|||:|.:|:|:|.||:
Zfish  1052 STYMAASGL-------NDSTYDKAGRSHIRALADYAMRLMDQMKYINEHSFNNFKMKIGLNMGPV 1109

  Fly  1021 TAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQL 1085
            .|||||||||.||||||||||||||:|||....||||.:...:|..:.||...||:|.|||||::
Zfish  1110 VAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLSSYNYTLEYRGVVKVKGKGEM 1174

  Fly  1086 MTFYLQGKSQSS 1097
            ||::|.|...:|
Zfish  1175 MTYFLNGGPNNS 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	46/163 (28%)
		CYCc	256..453	CDD:214485	112/197 (57%)
		Guanylate_cyc	294..476	CDD:278633	102/181 (56%)
		CYCc	860..1071	CDD:214485	107/211 (51%)
		Guanylate_cyc	892..1092	CDD:278633	108/200 (54%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	62/255 (24%)
		CYCc	354..548	CDD:214485	112/193 (58%)
		Guanylate_cyc	390..574	CDD:278633	103/191 (54%)
		DUF1053	598..687	CDD:283888	21/113 (19%)
		CYCc	961..1155	CDD:214485	106/201 (53%)
		Guanylate_cyc	987..1181	CDD:278633	108/200 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710