Protein Alignment Ac3 and adcy6b

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_002666536.2
• Gene: adcy6b / 560807
• ZFINID: ZDB-GENE-090127-2
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1191
• Identity: 393/1191 - (32%)
• Similarity: 605/1191 - (50%)
• Gaps: 198/1191 - (16%)

  Fly     8 GQKTIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGGVVILPQH----VLNELYHNYSIKQRRS 68
            |.:.:....:....|||    :..|....|||...|      |..    .|..|.|.:..|:.:|
Zfish    87 GLRAVDLAFEDAETRQT----KNGDDPDEGGVERKG------PDRCFFTCLLRLAHIFQSKKFKS 141

  Fly    69 GLKWFVFAAALFNIWTIGIPWDQSAPTR-----VINCCMLLAY--------------------LA 108
            .....::....|.:       :||:.|.     |:.|.::||:                    |.
Zfish   142 AKLERLYQRYFFRL-------NQSSLTMLMGVLVVVCGVMLAFHCVQGPPDVAYASVLSVAMGLF 199

  Fly   109 LTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQ--------PSFSPRDLLGW 165
            ||.::...|..       |||       ..:|::|.|...|.|::|        |...|.. :.|
Zfish   200 LTLMVVCNRNG-------FHQ-------DYMWIVSYLVMGVLVVVQVFGLLMVDPPSMPEG-IWW 249

  Fly   166 AILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLL 230
            .:...:::|..||::: ...:..|.:...|.:.:...::..||.|..||.|||::.....:||:.
Zfish   250 TVFFIYIIYTLLPVRM-RAAVITGAVLSTIHIVMAWRFNLEDSFLYKQLCANAMIFLCTNIIGIC 313

  Fly   231 YYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE-AFKKI 294
            .::..|..|::||.|.:..::.::.::.::.:||||||||||:|||::|:.|:.:...: .|.||
Zfish   314 THYPAEVSQRQAFKETRGYIQARIHLQRENQQQERLLLSVLPRHVAMEMKADINAKKEDMMFHKI 378

  Fly   295 YMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISG 359
            |:.:|:|||||:|||.|||:::|..:||:||..|||||||||:||.:...||||||||||||:||
Zfish   379 YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAWENHCLRIKILGDCYYCVSG 443

  Fly   360 APDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVE 424
            .|:.|.|||..||.||:.|::||..|::.....|:||||||:|.|..|:||.|:|||||:|.||.
Zfish   444 LPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVT 508

  Fly   425 LANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAK 489
            |||:||:.|||||:||:..||.:|||::||||.||..|...|....::|:|:.        .|::
Zfish   509 LANQMEAGGKAGRIHITKATLQYLNGDYEVEAGFGGDRNAYLNNNNIETFFVL--------GCSQ 565

  Fly   490 KINETQAEIAH-----------------PNPNGSTT-----------DIVSDEDDNDATLDDEEL 526
            |..|.:|.:|.                 |:.:.|.|           |..|.:|:..|   .|.|
Zfish   566 KRKEEKAMMAKMQRARANSSEGLMPRWVPDRSFSRTKDSKVFRQMGIDEASSKDNRCA---QEAL 627

  Fly   527 LAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLY 591
            ..::.|.  ..:|.|:.|...:|::.::.|:.|                    |.|:.|.||:.|
Zfish   628 NPEDEVD--EFLGRAIDARSIDQLRKDHVKKFL--------------------LTFQTPLLEKKY 670

  Fly   592 AVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLH---FINIAAPLVPIAMLVVISLAESFSGM 653
            :...:......:...|||.|..|....::.|.:.|.   ||.|   .:.:|.::.|....|...:
Zfish   671 SKKVDDRFGGYVACTLLVFCFIVFIQIVIFPHTPLMLGLFITI---FIILAHVLFICAIYSCVKL 732

  Fly   654 LPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTE-------HI-VSESEFN 710
            .|.....||||.........|..:...|.:..|..::||   |..||:       |: :|||
Zfish   733 FPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFVNMF---TCDRTDMLACVAGHLNISES--- 791

  Fly   711 VTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTH 775
            ||..|..:::.:.|.        |.........|.|     .|.|.:...:|.|:..:|...::.
Zfish   792 VTLCLLYNLSGLAED--------PFFLCLDQPSACP-----LPEYFTYSVLLTLLCCSVFLHISS 843

  Fly   776 LTKILLLLSIAALHCYFNIF---------------IMQDLYAL-EDDFEHQPI--ISTRYAASGL 822
            :.|::|:|.|..  |:..:.               .:..|||. |.::..:.:  :|.|.:...:
Zfish   844 IGKLVLMLFIQI--CFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQETVTKVSLRVSIPVI 906

  Fly   823 LLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKR 887
            |.|..|||...|:.::...|:.|.||.:..|:||...:::..|..|::|:||..||.||:...:|
Zfish   907 LTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR 971

  Fly   888 SHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKI 952
             :|:||.||...|.|:|||:.|||:||:|...||:|:||||.|||:|:|||.::...:::.:.||
Zfish   972 -NDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEIIADFDEIISEEKYKQLEKI 1035

  Fly   953 KTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINH 1017
            ||||||||||||:|      :.....|..:|:..|.::|:.|:..::.|||.|||:|.:|:|:|.
Zfish  1036 KTIGSTYMAASGLN------DSTYDKEGRTHILALADYAMRLREQMKYINEHSFNNFQMKIGLNI 1094

  Fly  1018 GPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGK 1082
            ||:.|||||||||.||||||||||||||:|||....||||.:..::|...||....||||.||||
Zfish  1095 GPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKGYQLECRGLVKVKGK 1159

  Fly  1083 GQLMTFYLQGKSQSSAEPVAS 1103
            |.:.|::|      ::.||.|
Zfish  1160 GDMTTYFL------NSGPVCS 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	145/341 (43%)
		Guanylate_cyc	294..476	CDD:425528	104/181 (57%)
		Guanylate_cyc	892..1092	CDD:425528	105/199 (53%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	74/321 (23%)
		Guanylate_cyc	378..562	CDD:425528	105/191 (55%)
		Adcy_cons_dom	590..678	CDD:461877	22/112 (20%)
		Guanylate_cyc	975..1169	CDD:425528	105/205 (51%)