Protein Alignment Ac3 and si:dkey-206f10.1

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_009293230.1
• Gene: si:dkey-206f10.1 / 560719
• ZFINID: ZDB-GENE-041014-154
• Length: 1187
• Species: Danio rerio
• Alignment Length: 1199
• Identity: 390/1199 - (32%)
• Similarity: 616/1199 - (51%)
• Gaps: 191/1199 - (15%)

  Fly     2 EANLENGQKTIAS-TSKSHSQRQTTSRR--------RQNDSDVAGGVGI---------TGGGVVI 48
            :|.:|...|.|.| .|:..::|:::..|        |.:.|....|..:         ...|.:|
Zfish    63 DAYIEEINKQIRSKASRGMTKRRSSVARVHPSFFGERSSSSSTQTGTSVDYISDADFFVHWGNII 127

  Fly    49 LPQHV-----------LNELYHNYSIKQRRSGL--KWFVFAAALFNIWTIGIPWDQSAPTR---- 96
            ...||           |.:||..:|...||:.|  ...:.|||..:::.:.:   ..||.|
Zfish   128 HGVHVPTLRHIFKSKDLEKLYQRHSSHTRRTSLVVTNIIDAAAKLHLFLLYL---ALAPDRSDIL 189

  Fly    97 -------VINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWL---LSILHFTVYV 151
                   .:.|.:.|..|.||.     :||..|....:       ...|.||   ..:|....|.
Zfish   190 MSWFTGFFMACAIALCVLVLTC-----KRSHSPKWLHY-------AGMASWLSQTAQVLGGLAYG 242

  Fly   152 ILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSL-LSNQLA 215
            :      .||...:.:...|..|..|||.|:: .:..|.:|..:.|:... ..|...: |..:|.
Zfish   243 L------ERDQSWYVLFTLFATYTLLPLPLLW-AIGAGTLTSILHLTAET-IRHISEVGLFRKLL 299

  Fly   216 ANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMR 280
            |.|:|..:..:.||..:::.:..|::||||.::.:|.:|.:|.::..||||:||:||:.||::|.
Zfish   300 AKALLYTSMNVAGLFIHYLTDRSQRQAFLETRRCIEGRMKLETENQRQERLVLSILPRFVALEMI 364

  Fly   281 EDLGSSSSE----AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEK 341
            .|:.|...|    .|.|:|:.::::||||:|||.|||.:|...|||:||::|||||.|||||||:
Zfish   365 SDMTSMDDELDPQQFHKVYIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLNELFGRFDRLAEE 429

  Fly   342 YQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLA 406
            |..||||||||||||:||.|:.:..||..||.|||:|:..::.::::.|..:|||:|||||:||.
Zfish   430 YDCLRIKILGDCYYCVSGVPEPQRAHARCCVEMGLAMISTMRSLRKQQNFDMDMRIGIHTGSVLC 494

  Fly   407 GILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGL 471
            |:||.::|||||:|.||.:||.:|:.|..||:|||..||..|:|.|:.|...|.:|.|.||...:
Zfish   495 GVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIHISRATLDCLDGSFQTEDGRGYERNEFLRKHNI 559

  Fly   472 KTYFITKVVKAFASPCAKK--INETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSN 534
            .|:.|          |.|:  :||.:||  ||....:....            ::|:||  |.||
Zfish   560 DTFLI----------CHKEDDLNEMEAE--HPKTRHNNRPW------------NKEILA--SFSN 598

  Fly   535 GHQIGIAVTA-----DEEEQVKLEN-----FKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQ 589
            |....:..::     .:|...::|:     ..:|::.|.:           |.:.|.||:..:|:
Zfish   599 GSYTQLPTSSACRSMSKEINKRIEHAIDLRSSERMRQEHI-----------TPVTLVFKDAHIEE 652

  Fly   590 LYAVYREPYSSLPLLAA----LLVQCIDVLYSYLVLPRSTL-HFINIAAPLVPIAMLVVISLAES 649
            .::..|:......|:.:    ||:..:..|   :.:||..| ..:.....|:...:|:|:.|||.
Zfish   653 KFSQVRDEMFKTNLVCSFIMLLLLMAVQAL---IPVPRMYLWTVLQFCLFLLGYLLLLVMVLAEE 714

  Fly   650 FS---GMLPKFFVDVSKRFNDITFVRELAAI-IIALTIGFSNVIDMFFFVTFVRTEHIVSESEFN 710
            |.   |:|.:|...:    ::...:|.|..| .||:..|.: :.||.:          .:.||..
Zfish   715 FKHSPGVLQQFCCWI----HENNSMRNLLTITAIAMNFGMA-LFDMMW----------CNSSEMK 764

  Fly   711 VTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTH 775
            ..::.|:      ||....:.              |.....||......||:.::..||..:::.
Zfish   765 EISTRET------EGYKAGQK--------------PLTACTYPEVFVLSGVVSMVTCAVFLRMSS 809

  Fly   776 LTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIIS----TRYAASGLLLVAALALSTL--A 834
            |.|:.:||.:.|::.||.......||..:.:.||   :|    .|.....:||:|...::.|  .
Zfish   810 LLKLTILLFVVAVYTYFIEVSFHMLYVHQQEHEH---LSRSHFLRRKGVSILLMAMFMIAVLYNG 871

  Fly   835 RHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAE 899
            |..:...|:.|.|:.:..::.:...|:|:.||.|::|:||.|||.||::. .|:..:||||||.|
Zfish   872 RRWEATTRLDFLWRLQAQQEVQEMRDLREHNECLLHNILPAHVARHFLER-NRNDQELYSQSYDE 935

  Fly   900 VGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASG 964
            |||:|||:..|:|:|.::.:.::|:|||:.|||:|:|||.|||...|.||.|||||||.||||||
Zfish   936 VGVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELLEESYFLDIEKIKTIGSCYMAASG 1000

  Fly   965 INVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARK 1029
            ::..:..|    :...|.||:.||.|||.::..|:.||:.|.|:|.|::||.|||:.||||||.|
Zfish  1001 LSPDKQSR----VVNDWHHLSELVLFALAMQETLREINKHSMNNFQLRVGIAHGPVVAGVIGATK 1061

  Fly  1030 PHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG----KGQLMTFYL 1090
            |.|||||.|||:||||:|||.:|.|||.|.|.|||..:|:....||.:.:||    ||::.|:::
Zfish  1062 PQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFI 1126

  Fly  1091 QGKSQSSAEPVASGVVVLNGQDSSAVEST 1119
            ..|.:.    |:|..:...|::.....:|
Zfish  1127 STKRRL----VSSNGIADRGKNGHTGRTT 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	138/340 (41%)
		Guanylate_cyc	294..476	CDD:425528	96/181 (53%)
		Guanylate_cyc	892..1092	CDD:425528	107/203 (53%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:318454	67/267 (25%)
		Guanylate_cyc	382..564	CDD:425528	96/181 (53%)
		Adcy_cons_dom	<603..662	CDD:461877	10/69 (14%)
		Guanylate_cyc	928..1126	CDD:425528	107/201 (53%)