Protein Alignment Ac3 and npr1a

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001038402.1
• Gene: npr1a / 560653
• ZFINID: ZDB-GENE-060503-539
• Length: 1067
• Species: Danio rerio
• Alignment Length: 1196
• Identity: 234/1196 - (19%)
• Similarity: 416/1196 - (34%)
• Gaps: 408/1196 - (34%)

  Fly   131 LLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILL-----NFLVYVTLPLQLIF------L 184
            |.:|:|        ||.|.|....|...|  .|.||:..     |.|  ....|||:|      .
Zfish    49 LAVILP--------LHNTEYPWAWPRVGP--ALYWALEKVNSDPNLL--AGYHLQLVFNSSENKE 101

  Fly   185 GLSIGCITYFICLSLPVGY---------------------SHWD--SLLSNQLAANAVLIATAAL 226
            ||....:...:.:.|...|                     :||:  .:.|...|....|.::...
Zfish   102 GLCSDSVAPLVAVDLKFSYNPWAFIGPGCDYSSSPVARFTTHWEVPMITSGARALGFNLYSSITN 166

  Fly   227 IGLLYYFMGE--AKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAI-----KMREDLG 284
            ||..:..:||  .:..|.|...|.:    |::...:...:|      |.:.|:     :||||
Zfish   167 IGPTHKKLGEFVLRMHRHFGWDKHA----MLMFNDNKNDDR------PCYFAVEGPYTQMRED-- 219

  Fly   285 SSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLN----------------ELFA 333
                            |::   ||.:.|..........:|::.::                :|..
Zfish   220 ----------------NIT---ADDLVFNEDEEPLRYDELLRDISHKARVVYVCCKWETFRKLMV 265

  Fly   334 RFDRLA---EKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKY----------- 384
            .|.|..   |:|....|.:.|.........|..|.|............||.:.|
Zfish   266 EFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGDADDNAAKEAFKSVKILTYREPQNPEYKDF 330

  Fly   385 VQQKANSPVDM-------------RVGIHTGAVL-----------------AGILGQRQWQFDVY 419
            |.:.....:||             ....|.|.:|                 ..::.:|.|....:
Zfish   331 VSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYH 395

  Fly   420 SKDVELANKMESSGKAGRVHI---SDKTLAFL--------NGEFEVEAAFGEKREELLRIAGLKT 473
                         |..|.|.:   .|:.:.|.        .|::::.:.:...:::::...|:|.
Zfish   396 -------------GVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKV 447

  Fly   474 YFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDI--VSDEDDNDATLDDEELLAQNSVSNGH 536
            :::.                     ..|.|     ||  ...::||.|.|.....:        |
Zfish   448 HWLK---------------------GRPPP-----DIPECGFKNDNPACLAKTVTM--------H 478

  Fly   537 Q-----------IGIAVTADEEEQVKLEN------FKQRLKD----------------------- 561
            |           |.:.||.....::||||      ::...:|
Zfish   479 QMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRRACSKLTISLRG 543

  Fly   562 ----ELVTRDGHENLTKDTNIF------LRFKNP-----------QLEQLYAVYREPYSSLPLLA 605
                .|:|.||:..:...|..:      :::.|.           :|:.:..|..|.      |.
Zfish   544 SNYGSLLTMDGNFQIYAKTGYYKGNITAIKYVNKKRIELTRKVLFELKHMRDVQNEH------LT 602

  Fly   606 ALLVQCID-----VLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRF 665
            ..:..|||     :|..|  .||.:|.                 .|.||....|...|     |:
Zfish   603 RFIGACIDPPNICILTEY--CPRGSLQ-----------------DLMESEGITLDWMF-----RY 643

  Fly   666 ---NDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEF--NVT----ASLESDINL 721
               |||  |:.:|.:..::.:...|          :::.:.|.:|.|  .:|    .|...|.||
Zfish   644 SLINDI--VKGMAFLHNSVIVSHGN----------LKSSNCVVDSRFVLKITDYGLESFHKDSNL 696

  Fly   722 ------VVEGMVTAEHLL----PASFVEQMRDAVPTERVLYPSYLSNFGVLI------------- 763
                  ....:.||..||    |.:...|..|            :.:||:::
Zfish   697 DDVHAFYARQLWTAPELLRADNPPACGTQKGD------------VYSFGIILQELALLKGVFYLE 749

  Fly   764 --------LIAIAVIAQLTHLTKILLLLSIA------ALHCYFNIFIMQDLYALEDDFEHQPIIS 814
                    :|...|..:..:|..:|...|.:      .|.|:     .:|:....|..:.:.::.
Zfish   750 GPCLSPKEIIERVVEGRWPYLRPLLCPQSHSEEMGQLMLRCW-----SEDVNERPDFSQIKVLLR 809

  Fly   815 TRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAE 879
            ......|..::..| ||.:.::.::.:.:       |.|:.:..::.:::.|||:|.:||..|||
Zfish   810 KNNCGYGSNILDNL-LSRMEQYANNLEEL-------VEERTQAYHEEKRKAEALLYQILPHSVAE 866

  Fly   880 HFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELP 944
            ...:.     :.:.::::..|.:.|:.:..|:...:|.|    .:|.:..||::.:.|||:::
Zfish   867 QLKRG-----EMVQAEAFDSVTIYFSDIVGFTALSAEST----PMEVVTLLNDLYTCFDAIID-- 920

  Fly   945 QFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQS--INEQSFN 1007
            .| |:.|::|||..||..||:          |:.....|...:...:|.|..|:.|  |..:...
Zfish   921 NF-DVYKVETIGDAYMVVSGL----------PVRNGKLHAREIARMSLALLEAVHSFRIRHRPNL 974

  Fly  1008 HFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFL 1072
            ...|::||:.||:.|||:|.:.|.|.::|:|||.||||||.|:|..|.|:|.|..:|:.|....|
Zfish   975 QLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQL 1039

  Fly  1073 Q-RGLVAVKGKGQLMTFYLQGKSQSS 1097
            : ||.|.:||||::.|::|.|:..|:
Zfish  1040 ELRGDVEMKGKGRMRTYWLLGEISSN 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	42/194 (22%)
		CYCc	256..453	CDD:214485	39/272 (14%)
		Guanylate_cyc	294..476	CDD:278633	34/252 (13%)
		CYCc	860..1071	CDD:214485	66/212 (31%)
		Guanylate_cyc	892..1092	CDD:278633	67/202 (33%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380	76/455 (17%)
		ANF_receptor	66..421	CDD:279440	65/402 (16%)
		PK_GC-A_B	540..814	CDD:270944	56/332 (17%)
		TyrKc	554..808	CDD:197581	53/312 (17%)
		HNOBA	<823..868	CDD:285003	14/52 (27%)
		CYCc	847..1032	CDD:214485	64/206 (31%)
		Guanylate_cyc	874..1060	CDD:278633	67/202 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810