DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and si:ch211-132f19.7

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_688903.4	Gene:	si:ch211-132f19.7 / 560410	ZFINID:	ZDB-GENE-130530-619	Length:	1183	Species:	Danio rerio

Alignment Length:	1213	Identity:	382/1213 - (31%)
Similarity:	603/1213 - (49%)	Gaps:	206/1213 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KTIASTSKSH--SQRQTTSRRRQNDSDVAGGVGITGGGVV---ILP-------QHVLNELYHNYS 62
            |..:|.::.|  .:|.:|..|:..:|.......::.|..|   .||       .|.|..||..:|
Zfish    83 KRRSSAARIHPFRERNSTCTRKSTESVTDADFFVSWGSTVRGIFLPALHHKFKSHDLEHLYQQHS 147

  Fly    63 IKQRRSGLK-------------WFVFAAALFNI------WTIGIPWDQSAPTRVINCCMLLAYLA 108
            ..|||:.|.             .|::.|....:      |..|:.....|    |.|.::|....
Zfish   148 SGQRRTSLVVTNVIDILTKLHIIFIYLALAPEMVDSQHGWLAGLLMALGA----IICVLVLTCKG 208

  Fly   109 LTALLHIGRRSDKPALRRFHQILLIIVPRALWL---LSILHFTVYVILQPSFSPRDLLGWAILLN 170
            |.:          |...|:..:       |.||   :..|...||.:....       .|.:|..
Zfish   209 LMS----------PDYLRYAGL-------ASWLSQTVQALGGLVYGLETDQ-------SWYVLFT 249

  Fly   171 -FLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFM 234
             |.:|..|||.|:: .:.:|.:|..:.|.:....::.|:.:..:|.|..:|.......||..:::
Zfish   250 LFAIYTLLPLPLLW-SICMGFLTAALHLFVDTFKNYNDTAIVRKLLAKGLLYMGMNTAGLFIHYL 313

  Fly   235 GEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE----AFKKIY 295
            .:..|::||||.::.:|.::.:|.::..||||::|:||:.:|::|..|:.:...|    .|.|.|
Zfish   314 SDRAQRQAFLETRRCIEGRVKMERENQRQERLVMSILPRFIAMEMIGDMTALDDELLPQQFHKTY 378

  Fly   296 MSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGA 360
            ..::::||||:|||.|||::|.|..||:||:.|||||.|||||||:...:|||||||||||:||.
Zfish   379 FHQYKDVSILFADIKGFTSLSMTMPAQELVRTLNELFGRFDRLAEENHCMRIKILGDCYYCVSGV 443

  Fly   361 PDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVEL 425
            |:.:..||..||.|||:|:..|:||:::....:|||:|||:|:||.|:||.::|||||:|.||::
Zfish   444 PEPQTAHARCCVEMGLAMINTIRYVRKELKRDMDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVDV 508

  Fly   426 ANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKK 490
            ||.:|:.|..||:|||..||..|.|.:|.|...|.:|.|.||...:.|:.|....:....|  .|
Zfish   509 ANMLEAGGIPGRIHISRATLDCLEGVYETEEGRGHERNEFLRKHKIDTFLIRHTPQDDKEP--PK 571

  Fly   491 INETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSV----SNG------HQIGIAVTAD 545
            :..|.                .||....|.|..:.::..|.:    :||      :||.......
Zfish   572 VRRTS----------------KDETTWSAELPFDNIIGMNCILATFTNGSLVHLPNQITPHCAGS 620

  Fly   546 EEEQVKLENFKQRLKDELVTRDGHENLTKD--TNIFLRFKNPQLEQLYAVYREPYSSLPLLAALL 608
            .|       ..:|:|..:..|.. |.:.|:  |...|.||:..:|..::..|:......|..:.|
Zfish   621 RE-------INKRIKQAIEVRSS-ERMRKEHITPFTLVFKDTHIEGKFSQMRDEMFKSNLACSFL 677

  Fly   609 VQCIDVLYSYLVLPRSTLHFINIAAPLVP----------------IAMLV-VISLAESFSGMLPK 656
            :                |.||..|..|:|                :.||| :::|||.|. ..|.
Zfish   678 L----------------LLFIMAAQALIPSPQFFPMIIQFLVFLFVYMLVLLVTLAEEFK-RSPP 725

  Fly   657 FFVDVSKRFNDITFVRELAAI-IIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDIN 720
            :...:....::...:|.|..: .||:..|.::....:...||..||.....||..
Zfish   726 YLQHLCCWIHETKSIRNLLTLTAIAINFGVASCNIFWCNGTFEETEKSNKNSEHG---------- 780

  Fly   721 LVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSI 785
                              :|.    |.....:|.:....||:.::..||..:|:.|.|:.:|..:
Zfish   781 ------------------KQW----PVNICTHPEFFVLSGVVAMVTCAVFLRLSCLLKLAVLTLV 823

  Fly   786 AALHCY-----FNI-FIMQDLYALEDDFEHQPIISTRY---AASGLLLVAALALSTL--ARHMDH 839
            .|::.|     |:: ||.|        .::..|..::|   ....:||:|...:..|  :|.::.
Zfish   824 IAVYTYLIEVAFHVLFIRQ--------HQNSQIQRSQYLRRKGISVLLMAMFVVVVLYNSRQLET 880

  Fly   840 EDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLF 904
            ..|:.|.|:.:..::.|...::|:.||.|:||:||.|||.||::. .|:::||:|:||..|||:|
Zfish   881 TSRLDFLWRLQARQEVEDMKELREHNECLLYNILPAHVARHFLER-DRNNEDLFSESYERVGVMF 944

  Fly   905 ASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQR 969
            ||:|.|||:|.::.:.:|.:||||.|||:|:|||.||:.|.||||.|||||||.||||||::.::
Zfish   945 ASIPGFSDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEK 1009

  Fly   970 TVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDI 1034
            ....|     .|:||:.||.|||.::..|:.||:::.|.|.|::||:|||:.||||||.||.|||
Zfish  1010 QECED-----EWAHLSTLVLFALAMQETLKEINKRTSNDFWLRVGISHGPVVAGVIGATKPQYDI 1069

  Fly  1035 WGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG----KGQLMTFYLQGKSQ 1095
            ||.|||:||||:|||.:|.|||.|.|..:|...|:....||.:.|||    :|.:.|:::..:..
Zfish  1070 WGMTVNLASRMDSTGLSGRIQVPEATSRVLAEHGFMLQLRGEIYVKGVSERRGAVRTYFVSSREH 1134

  Fly  1096 SS--AEPVASGVVVLNGQDSSAVESTSELEASDIKMPLLKMNG 1136
            :|  ||...|..:.| |:::.|....|.::|.. |..|.:.||
Zfish  1135 NSSYAERNTSRGISL-GRNTLAAVVFSLVQARK-KEELREANG 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	40/161 (25%)
		CYCc	256..453	CDD:214485	101/200 (51%)
		Guanylate_cyc	294..476	CDD:278633	95/181 (52%)
		CYCc	860..1071	CDD:214485	113/210 (54%)
		Guanylate_cyc	892..1092	CDD:278633	105/203 (52%)
si:ch211-132f19.7	XP_688903.4	AC_N	<133..375	CDD:292831	61/270 (23%)
		CYCc	338..537	CDD:214485	100/198 (51%)
		Guanylate_cyc	381..559	CDD:278633	94/177 (53%)
		DUF1053	579..667	CDD:283888	20/95 (21%)
		CYCc	903..1103	CDD:214485	112/205 (55%)
		Guanylate_cyc	932..1131	CDD:278633	105/203 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710