DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac3 and ADCY10

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_060887.2 Gene:ADCY10 / 55811 HGNCID:21285 Length:1610 Species:Homo sapiens


Alignment Length:1112 Identity:205/1112 - (18%)
Similarity:365/1112 - (32%) Gaps:396/1112 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 YYFMGEAKQ-KRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKI 294
            ||..||.|. .|.....|...|::|.:      |:.::.|:| |.:..|..:.            
Human   239 YYPSGEHKNLLRLACTLKPDPELEMSL------QKYVMESIL-KQIDNKQLQG------------ 284

  Fly   295 YMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKIL----GDCYY 355
            |:|....|:|::.:::    ......|:::...:.:.:.....:.:.:|....|:.    |..:.
Human   285 YLSELRPVTIVFVNLM----FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFL 345

  Fly   356 CISGAPDER-PD---HAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQR-QWQ 415
            |:.|.|.|: ||   ||:.|..........:..:|       .:.:|:.:|.|..||:|.. :.:
Human   346 CVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQ-------TVSIGVASGIVFCGIVGHTVRHE 403

  Fly   416 FDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI---- 476
            :.|..:.|.||.:| .....|.|.....|   .||                  :.|..||.    
Human   404 YTVIGQKVNLAARM-MMYYPGIVTCDSVT---YNG------------------SNLPAYFFKELP 446

  Fly   477 TKVVKAFA--SPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNS-------- 531
            .||:|..|  .|..:....|:..:.     |....|.:.:       :|..||.:|.        
Human   447 KKVMKGVADSGPLYQYWGRTEKVMF-----GMACLICNRK-------EDYPLLGRNKEINYFMYT 499

  Fly   532 -----VSNGHQI----GIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQL 587
                 :||..|:    |:......:..:|:|...|.....::.    .:|.|     :.|.    
Human   500 MKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIA----ISLNK-----ISFH---- 551

  Fly   588 EQLYAV---------------YREPYSSLPLLAALLVQ----CI--DVLYSYLVLPR-----STL 626
            :..|.:               |:|..::|......|:.    |:  |:.:....:.|     |||
Human   552 QTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTL 616

  Fly   627 H--------FINIAAPLVPIAMLV-VISLAESFSGMLPKFFVD-VSKRFNDITFVRELAAIIIA- 680
            .        |:.|...:|....:: :|..|:         ||| .|.||.: ..:|.|...||. 
Human   617 KKQKQLEILFMKILKLIVKEERIIFIIDEAQ---------FVDSTSWRFME-KLIRTLPIFIIMS 671

  Fly   681 -----------------------LTIG------FSNVIDMFFFVTFVRTE--------------- 701
                                   :.||      .||.|.:...|:.:..|               
Human   672 LCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFY 736

  Fly   702 ----------HIV-----SESE----------FNVTASLESDINLVVEGMVTAEHLLPASFVEQM 741
                      |.|     :|||          |..:..|...:|     |||......:..|..:
Human   737 CEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLN-----MVTLHSDKESEEVCHL 796

  Fly   742 RDAVPTERVLYPSYLSNFGVL----------ILIAIAVIAQLTHLTKIL-----------LLLSI 785
            ...|..:.:..|:.|....::          :|:..|.|..||..|::|           ::.::
Human   797 TSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKTL 861

  Fly   786 AAL------HCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDH-EDRV 843
            |.|      :|:.|...:|.  ||:   ::.|.....|        .:|:|.. :..||| |:..
Human   862 ATLVESNIFYCFRNGKELQK--ALK---QNDPSFEVHY--------RSLSLKP-SEGMDHGEEEQ 912

  Fly   844 IFKWKTEVAE----------QKETANDMRQRNEALVYNV---------------------LPVHV 877
            :.:.:.||.|          .::||.::..:::....::                     :|.| 
Human   913 LRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDFIPYH- 976

  Fly   878 AEHFMKNTKRSHDDL-------YSQSYAEVGVLFAS---MPNFSDFYSEETVNNQGLE-CLRFLN 931
              ||..|.:.:..|:       .|..:.....|..|   :|..|.|:.|.....:..| .|.|.:
Human   977 --HFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEIREKILNFFD 1039

  Fly   932 EVI-----SDFDAL-LELPQFQDIIKIKTIG-----------------------------STYMA 961
            .|:     ||.|.: ||..|.::|::|..:.                             ..|||
Human  1040 HVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMA 1104

  Fly   962 ASGIN----VQRTVRNDAPITERWS-----------------HLAILVEFALELKHALQSINE-Q 1004
            ...:|    :.:|::.|    :.||                 ::..:|.....|:.||:.:|. .
Human  1105 YMYLNEGQKLLKTLKKD----KSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIF 1165

  Fly  1005 SFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVN-VASRMESTGKAGAIQVTEET-CNIL--R 1065
            .:|...|.:.|:       |...|..||      || .|......||....|:..:| |..|  |
Human  1166 PYNLISLFLHIH-------VEKNRHFHY------VNRQAQESPPPGKKRLAQLYRQTVCLSLLWR 1217

  Fly  1066 LFGYTFL 1072
            ::.|::|
Human  1218 IYSYSYL 1224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 14/54 (26%)
CYCc 256..453 CDD:214485 39/205 (19%)
Guanylate_cyc 294..476 CDD:278633 36/190 (19%)
CYCc 860..1071 CDD:214485 56/303 (18%)
Guanylate_cyc 892..1092 CDD:278633 51/253 (20%)
ADCY10NP_060887.2 CHD 40..214 CDD:143636
AcyC <42..197 CDD:225025
CHD 292..461 CDD:143636 40/201 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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