DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and adcy2b

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_005170095.1	Gene:	adcy2b / 557902	ZFINID:	ZDB-GENE-060503-69	Length:	1142	Species:	Danio rerio

Alignment Length:	1202	Identity:	390/1202 - (32%)
Similarity:	605/1202 - (50%)	Gaps:	190/1202 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TSKSHSQRQTT-------SRRRQNDSD---VAG------------------GVGITGGGVVILPQ 51
            |..||..:.:|       .|.:|.|.|   |:|                  .:|::..|:. .|.
Zfish    15 THLSHPPQLSTLTEEDEPERHKQQDEDDEEVSGVQQDPMFQQTAYLLEGPEDMGVSSCGLK-SPD 78

  Fly    52 HVLNELYHNYSIKQRRSGLKWFVF-------AAALFNIWTIGIPWDQ------SAPTRVINCCML 103
            .|    |.:|....::..|..|:.       .|.|...:..|:..::      :.||      .|
Zfish    79 WV----YESYYRMSQQHPLIVFLLLIVMGACLALLAVFFASGLDMEEHMAFIMTVPT------TL 133

  Fly   104 LAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAIL 168
            ..:||:..|:.| ....|..||.|.  |||      |...:....:::.......|.|.:.:.:.
Zfish   134 AIFLAIFILVCI-ESVFKKLLRLFS--LLI------WGCLVAMGYLFMFFGGIICPWDQVSFFLF 189

  Fly   169 LNFLVYVTLPLQL------IFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALI 227
            :.|:||..||..:      ..|..|...:...||||..  ..|.::|:. |:.||.::.....:.
Zfish   190 IVFVVYTMLPFSMRDAVIASVLTSSSHTLVLSICLSNT--SDHMEALVW-QILANIIIFICGNVA 251

  Fly   228 GLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL-----GSSS 287
            |..:..:.:...|:.:.:....::..:.:|.:..:|||||||:||.|:|..|:.::     |.:.
Zfish   252 GAYHKHLMDLALKQTYHDTCNCIKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEIIQRLKGPNF 316

  Fly   288 SEA-----FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRI 347
            |:|     |..:|:.||.|||||||||||||.::|..|..:||.||||||.:||::|:....:||
Zfish   317 SQAENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRI 381

  Fly   348 KILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQR 412
            |||||||||:||.||...|||..||.|||.|.:||:.|::.....::||||:|:|.||.|::|.:
Zfish   382 KILGDCYYCVSGLPDPLLDHAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQ 446

  Fly   413 QWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFIT 477
            :||:||:|.||.|||.||:.|..||||||..||..|||.::||...|:.|:..|:..|:.||.:
Zfish   447 KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEQGNGQSRDSYLKEHGIVTYLV- 510

  Fly   478 KVVKAFASPCAKKINETQAEIAHPNPNG----STTDIVSDEDDNDATLDDEELLAQNSVSNGHQI 538
                  .:|.|:|.:........|...|    ::..:....:...|......|..::|::|  :.
Zfish   511 ------INPKAEKRSPLLLSAIRPTMYGAKMRASVRMTQYLESWGAAKPFANLHHRDSMTN--EN 567

  Fly   539 GIAVTAD--------EEEQVKLENFKQRLKDELVTR-----DG---------HENLTKDTNIFLR 581
            |:..|.|        ::...:.::.|:|.::||..|     ||         .|::.:   |.|.
Zfish   568 GMINTRDVPLGQYNCQQRSERTKSQKKRFEEELNERIIRTIDGINSQKQWLKSEDIQR---ISLF 629

  Fly   582 FKNPQLEQLYAVYREPYSSLPLL------AALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAM 640
            |.|..||:.|..     ::||..      |.|:..||.:: ..||||::|:..::.....:.:|:
Zfish   630 FHNKALEKEYRA-----TTLPAFKYYVTCACLIFFCIFIV-QVLVLPKTTVLEVSFGMAFLLLAL 688

  Fly   641 LVVISLA-------ESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMF--FFVT 696
            ::.|..|       ::.|..:|: ....||...:..::|      :|||:..:.:|.:.  |.:.
Zfish   689 ILCICFAGHILQWGKAASCTMPR-LPSSSKVITNKPWIR------LALTMATTALILVMAVFNMF 746

  Fly   697 FVRTEHIVSESEFNVT-ASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFG 760
            |:..:.:|:.:..|:: :|::...     |.:|..                :....|..|.....
Zfish   747 FLGEDRMVASTSLNISNSSMDGPY-----GQITNS----------------SNNKFYLPYFIYSC 790

  Fly   761 VLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFE------HQP-----IIS 814
            :|.||:.:|..::.:..|::::|.....   :||.|:|...::.||:.      .||     :..
Zfish   791 ILGLISCSVFLRINYELKMIIMLGAVVA---YNIIILQTHASILDDYSMALYKTQQPDRPGVLKD 852

  Fly   815 TRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAE 879
            .:...|..|.:..:.|..|||..::..|:.|.|:.:..::.|....|...|..|:.||||.||||
Zfish   853 LKTMGSISLFIFFVTLLVLARQNEYYCRLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAE 917

  Fly   880 HFM-KNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLEL 943
            ||: :|.|  ::|||.|||..|.|:|||:|:|.:||:|..||.:||||||.|||:|:|||.||..
Zfish   918 HFLGRNWK--NEDLYHQSYDTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSK 980

  Fly   944 PQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNH 1008
            |:|..:.||||||||||||:|:||...:........::.|:..:||||..|...|..||:.|||.
Zfish   981 PKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKLDVINKHSFND 1045

  Fly  1009 FVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQ 1073
            |.:::||||||:.||||||:||.||||||||||||||||||..|.|||||||..||:..||....
Zfish  1046 FRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETNWILQTLGYMCSC 1110

  Fly  1074 RGLVAVKGKGQLMTFYL-----QGKSQSSAEP 1100
            ||::.|||||.|.||::     |..||.:..|
Zfish  1111 RGIINVKGKGDLRTFFVHTEMTQSLSQGNVMP 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	38/168 (23%)
		CYCc	256..453	CDD:214485	107/206 (52%)
		Guanylate_cyc	294..476	CDD:278633	98/181 (54%)
		CYCc	860..1071	CDD:214485	122/211 (58%)
		Guanylate_cyc	892..1092	CDD:278633	116/204 (57%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831	56/248 (23%)
		CYCc	283..486	CDD:214485	106/202 (52%)
		Guanylate_cyc	328..512	CDD:278633	98/190 (52%)
		DUF1053	542..646	CDD:283888	23/113 (20%)
		CYCc	899..1106	CDD:214485	120/208 (58%)
		Guanylate_cyc	929..1128	CDD:278633	116/198 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710