Protein Alignment Ac3 and adcy1a

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1121
• Identity: 381/1121 - (33%)
• Similarity: 590/1121 - (52%)
• Gaps: 177/1121 - (15%)

  Fly    54 LNELYHNYSIKQRRS----GLKWFVFAA---ALFNIWTIGIPWDQSAPTRVINCCML-------- 103
            |..|:..|::|..::    .|...:.||   ||..:.:.|..:..|..:..::|.:.
Zfish    37 LETLFQKYNLKLEQTATLKALAILILAASALALVELLSAGSRFTVSKGSHPVHCVIFTSLFIVTN 101

  Fly   104 LAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFT--VYVILQPSFSPRDLLGWA 166
            :.||.:|.|..|.|.    ||.......|:..|   :.|::.|.|  .:....||.:|...:...
Zfish   102 VKYLQVTQLQQIARL----ALLFSFTFALLCCP---FPLALGHGTQGTHGPDAPSTTPEQGVWQL 159

  Fly   167 ILLNFLVYVTLPLQLIFLGLSIGCI---TYFICLSLPVGYSH---WDSLLSNQLAANAVLIATAA 225
            :|:.|:.|..||::.: |.:..|.:   ::||..:..|....   |     ..|.|||||:....
Zfish   160 MLVTFVAYSLLPVRTL-LAVLFGVLVAASHFIVTATSVTARRPRVW-----TPLVANAVLLVGVN 218

  Fly   226 LIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEA 290
            |.|:......|..|::|||:|:..::.::.:|:::.:|||||:|:||::||::|:||........
Zfish   219 LSGVFVRVRTERAQRKAFLQARNCIQQRLQLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERI 283

  Fly   291 FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYY 355
            |.|||:.||:|||||:|||||||:::|..:||:|||:|||||.:||.||.:....||||||||||
Zfish   284 FHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYY 348

  Fly   356 CISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYS 420
            |:||....:.|||..||.|||.|:..|..|.:.....::||||:|||.||.|:||.|:||:||:|
Zfish   349 CVSGLTQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS 413

  Fly   421 KDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFIT-------- 477
            .||.|||.||:.|..|:|||:..||..|||::|||..||.:|...|....::|:||.
Zfish   414 NDVTLANMMEAGGLPGKVHITKATLECLNGDYEVEPGFGHERHAFLSKHAIETFFIVPSHRRKIF 478

  Fly   478 --------KVVK--AFASPC--------AKKINETQAEIAHPNPNGSTTDIVSDEDDND---ATL 521
                    |..|  .|.:.|        .:|:  .:|||...|       :::.|||:.   ...
Zfish   479 PGLILSDIKPAKRMEFKTVCYLLVQLMHCRKM--FKAEIPFSN-------VMTCEDDDKRRALRT 534

  Fly   522 DDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTN-IFLRFKNP 585
            ..|:|..:.|.|.|       ........::..:..||.:...|    |:...|.| |.|.:::.
Zfish   535 ASEKLRNRTSFSAG-------MVQNSPGTRVNRYIGRLIEARQT----ESEMADLNYITLTYRSR 588

  Fly   586 QLEQLY-AVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAES 649
            :.||.| .||.:.:.|..:::.:|.....|:| :|::|:..|           :.:|:|:.|.
Zfish   589 EREQRYLQVYDDAFISAVVISLVLTSFFAVVY-FLIIPQGLL-----------VVILLVLCLC-- 639

  Fly   650 FSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTA- 713
                    |...|..:..:|.|:   .....||:....|:..|..:..           ::||.
Zfish   640 --------FHMASVMYLHVTHVQ---CSPDCLTLQIRTVLCGFLVLLM-----------YSVTQG 682

  Fly   714 --------SLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVI 770
                    |||.:.::.:..:||..           ...|......|..|:....|:..:::|:.
Zfish   683 CVVTCVPWSLEGNSSISMVTVVTVN-----------GTGVGYRVCKYTPYVFLSCVMASLSVALY 736

  Fly   771 AQLTHLTKILLLLSIAALHCYFNIFIMQDLY--ALEDDFEH----QPIISTRYAASGLLLVAALA 829
            .:::.|.||||||.:..||   .:.:....|  |:...|.|    .|:::.      ||...||.
Zfish   737 LRVSSLPKILLLLLLNILH---TVVMETSGYRKAVGGGFFHTHGYDPVLAM------LLFSGALV 792

  Fly   830 LSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYS 894
            |.  .|.:|.:.|:.:.|.|:..|:::....::..|:.:::|:||.|||:||:.:..|:. |||.
Zfish   793 LH--CRQLDLKLRLDYLWATQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLLSNPRNM-DLYY 854

  Fly   895 QSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTY 959
            |||::|||||||:|||:|||.|...||.|:||||.|||:|:|||||::...::||.|||||||||
Zfish   855 QSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDALMDKECYRDIEKIKTIGSTY 919

  Fly   960 MAASGI------NVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHG 1018
            |||.|:      .|::::.         :||..:.::|:|:...|.:||.||:|.|||::|||.|
Zfish   920 MAAVGLVPTEGSKVKKSIS---------AHLCTVADYAIEMFDVLDAINYQSYNDFVLRVGINVG 975

  Fly  1019 PITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKG 1083
            |:.|||||||:|.||||||||||||||:|||..|.|||||:...:|..: |.|..||.|:|||||
Zfish   976 PVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVFRLLSGY-YDFNCRGQVSVKGKG 1039

  Fly  1084 QLMTFYLQGKSQSSAE 1099
            |::|::|:|::...|:
Zfish  1040 QMLTYFLEGRTPQGAQ 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	47/165 (28%)
		CYCc	256..453	CDD:214485	106/196 (54%)
		Guanylate_cyc	294..476	CDD:278633	98/181 (54%)
		CYCc	860..1071	CDD:214485	113/216 (52%)
		Guanylate_cyc	892..1092	CDD:278633	114/205 (56%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831	39/136 (29%)
		CYCc	251..446	CDD:214485	105/194 (54%)
		Guanylate_cyc	287..469	CDD:278633	98/181 (54%)
		DUF1053	513..601	CDD:283888	25/105 (24%)
		CYCc	819..1029	CDD:214485	114/220 (52%)
		Guanylate_cyc	852..1048	CDD:278633	114/205 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710