Protein Alignment Ac3 and Adcy4

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_062158.2
• Gene: Adcy4 / 54223
• RGDID: 2034
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1104
• Identity: 379/1104 - (34%)
• Similarity: 560/1104 - (50%)
• Gaps: 163/1104 - (14%)

  Fly    83 WTIG--IPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSI- 144
            |..|  :..|.|..|.|:  |.|..:..|     :|..|.:..|:|:.:.|..::..||..|..
  Rat    49 WASGRELTSDPSFLTTVL--CALGGFSLL-----LGLASREQQLQRWTRPLSGLIWAALLALGYG 106

  Fly   145 LHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLS--IGCITYFICLSLPVGY---S 204
            ..||..|:     |..|.:.:.:.:.|.||..|||.:.....:  |..:::.:.|.|.:|:   |
  Rat   107 FLFTGGVV-----SAWDQVSFFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWRPES 166

  Fly   205 HWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLS 269
            ..|  |..||||||||.....::|..:..:.|...:..|.||..||..:..::.:...||.||||
  Rat   167 QRD--LLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLS 229

  Fly   270 VLPKHVAIKMREDL------GSSS----SEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDL 324
            :||.::|.:|:.::      |.||    :..|..:|:.||:.||:|||||||||.::|..|.::|
  Rat   230 ILPAYLAREMKAEIMARLQAGQSSRPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKEL 294

  Fly   325 VKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKA 389
            |.||||||.:||::|::::.:|||||||||||:||.|...||||:.||.|||.|.:||:.::...
  Rat   295 VLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVAT 359

  Fly   390 NSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEV 454
            ...::||||:|:|:||.|::|.::||:||:|.||.|||.||:.|..|||||:..|||.|.|.:.|
  Rat   360 GVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAV 424

  Fly   455 EAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDA 519
            |.|..|.|:..||..|..||.:       ..|.|::.:|          .|:...::|..:.:
  Rat   425 ERADMEHRDPYLRELGEPTYLV-------IDPWAEEEDE----------KGTERGLLSSLEGH-- 470

  Fly   520 TLDDEELLAQNSVSNG------HQIGIAVTADEEEQVKLENFKQR-----------LKDELVTRD 567
            |:....|:.:...|.|      |...:...|.....:..:.|..:           |.|||.|.|
  Rat   471 TMRPSLLMTRYLESWGAAKPFAHLSHVDSPASTSTPLPEKAFSPQWSLDRSRTPRGLHDELDTGD 535

  Fly   568 GH-----ENL--------TKDTNIF-LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSY 618
            ..     |.|        :||.|:. |.|:..::|:.|.:...|..........||...:.....
  Rat   536 AKFFQVIEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQM 600

  Fly   619 LVLPRSTLHFINIAAPLVPIAMLVVISLAESFS----------GMLPKFFVDVSKRFNDITFVRE 673
            ||..|........:...:...:|:.:..:|..:          ..||...|.|:.| ..:.....
  Rat   601 LVTTRPPALATTYSITFLLFLLLLFVCFSEHLTKCVQKGPKMLHWLPALSVLVATR-PGLRVALG 664

  Fly   674 LAAIIIALTIGFSNVIDMFFF-----VTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLL 733
            .|.|::..|:.   |:.:.|.     ..|:...  ||...||.:..|.:.:.|:
  Rat   665 TATILLVFTMA---VVSLLFLPVSSDCPFLAPN--VSSVAFNTSWELPASLPLI----------- 713

  Fly   734 PASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQ 798
                      ::|        |..:..||..::.::...::...|:||||......|  ::|:..
  Rat   714 ----------SIP--------YSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLVASC--SLFLHS 758

  Fly   799 DLYALEDDFEHQPIISTRYAAS-----GLL----LVAAL-------ALSTLARHMDHEDRVIFKW 847
            ..: |.|     .:|:..|..|     |:|    |:.|:       .|..|||..::..|:.|.|
  Rat   759 HAW-LSD-----CLIARLYQGSLGSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLW 817

  Fly   848 KTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSD 912
            |.::.:::|....|......|:.||||.|||..|:...:| ::|||.|||..|.|||||:|:|.:
  Rat   818 KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-NEDLYHQSYECVCVLFASIPDFKE 881

  Fly   913 FYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQ--RTVRNDA 975
            ||||..:|::||||||.|||:|:|||.||..|:|..:.||||||||||||:|:|..  :..:.||
  Rat   882 FYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGQDTQQDA 946

  Fly   976 PITER-WSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTV 1039
               || .|||..:||||:.|...|..||:.|||:|.|::|:||||:.||||||:||.||||||||
  Rat   947 ---ERSCSHLGTMVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTV 1008

  Fly  1040 NVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVAS 1103
            ||||||||||..|.|||||||...|:..|||...||::.|||||||.|::|......:..|.||
  Rat  1009 NVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGSPSAS 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	139/348 (40%)
		Guanylate_cyc	294..476	CDD:425528	96/181 (53%)
		Guanylate_cyc	892..1092	CDD:425528	123/202 (61%)
Adcy4	NP_062158.2	AcyC	40..453	CDD:441717	162/424 (38%)
		Guanylate_cyc	264..430	CDD:425528	89/165 (54%)
		Adcy_cons_dom	479..581	CDD:461877	21/101 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..523		2/24 (8%)
		AcyC	648..1053	CDD:441717	174/451 (39%)
		Guanylate_cyc	861..1060	CDD:425528	122/201 (61%)