DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	305	Identity:	81/305 - (26%)
Similarity:	148/305 - (48%)	Gaps:	41/305 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 ATAALIGLLYYFMGEAK--QKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLG 284
            ||..|:.|...|..|.|  |:...|..:..|.:: .:|::..:.:.||.||||..||.::|..
Mouse   348 ATRDLVLLGEQFREEYKLTQELEILTDRLQLTLR-ALEDEKKKTDTLLYSVLPPSVANELRHK-- 409

  Fly   285 SSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYS----AQDLVKMLNELFARFDRLAEKYQQ- 344
                   :.:...|::||:||::.||||.|..|.::    |..:|.:||:|:.|||.|.:..:.
Mouse   410 -------RPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNP 467

  Fly   345 --LRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAG 407
              .:::.:||.|..:||.|:....||....|:.|.|::....||....| |.:.:|||||.|:.|
Mouse   468 FVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGES-VQITIGIHTGEVVTG 531

  Fly   408 ILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLK 472
            ::|||..::.::...|.|.::.|::|:.|::::|:.|...|...        |..:.|..:
Mouse   532 VIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSP--------ENSDPLFHL---- 584

  Fly   473 TYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDN 517
                     ....|.:.|..:...::...:...:.|:..::||:|
Mouse   585 ---------EHRGPVSMKGKKEPMQVWFLSRKNTGTEETNEEDEN 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	20/64 (31%)
		CYCc	256..453	CDD:214485	63/203 (31%)
		Guanylate_cyc	294..476	CDD:278633	55/188 (29%)
		CYCc	860..1071	CDD:214485
		Guanylate_cyc	892..1092	CDD:278633
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572
		HNOBA	207..406	CDD:311573	19/58 (33%)
		Guanylate_cyc	412..605	CDD:306677	57/214 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900