Protein Alignment Ac3 and ACXA

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Alignment Length: 1150
• Identity: 306/1150 - (26%)
• Similarity: 522/1150 - (45%)
• Gaps: 224/1150 - (19%)

  Fly    54 LNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTR--VINCCMLLAYLAL-TALLHI 115
            |.|.|..|.|:...|.|..||....|..:....|.|..:..|:  .||....|..|.| |.||.|
  Fly    42 LEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSI 106

  Fly   116 GRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPL- 179
            ....|.....|:.......:...:.:|..:.|..|...:.:: |.:.| :.:.:..::|:.||:
  Fly   107 NFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNW-PLNTL-YDVFVLCMIYMFLPIP 169

  Fly   180 -----QLIFLGLSIGCITYFICLSL-----PVGYSHWDSLLS----NQLAANAVLIATAALIGLL 230
                 .|:.:.:|:..:.|||....     ...|.|...::|    :.|..|        ::|:.
  Fly   170 SSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFN--------MMGIF 226

  Fly   231 YYFMGEAKQKRAFLEAKKSLEVKMVIEE----QSAEQERLLL-SVLPKHVAIKMRED-------- 282
            :..|.:...:.:||:     ..:.:.||    |:..||.||| |:||..:|..:::.
  Fly   227 FRIMNDTMVRSSFLD-----RYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQP 286

  Fly   283 ------LGSS-SSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAE 340
                  ||:| ::|.|..|.:  |.:|||||||:|.:|.:::|.:.:.|||:|::|:||||..|.
  Fly   287 DNDFYHLGTSRTAENFMSIQI--HNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAAL 349

  Fly   341 KYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVL 405
            .::..|||.|||||||::|..:..||||.:.|.:|:||:..||.|....:..:.||:|:|:|.:.
  Fly   350 SFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLF 414

  Fly   406 AGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNG-EFEV----EAAFGEKREEL 465
            ||::|:.:.|:|::..||.:|:::|::|..|.||:|.:||:.||. |:.:    |:|   :::.:
  Fly   415 AGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESA---QKDPV 476

  Fly   466 LRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQN 530
            |:...:.||.:|      |.|...  ::....|....||.....:.|:.        ..::|..|
  Fly   477 LQKHPMSTYLLT------AIPSLD--SDKTISIVEGVPNLDLQTVGSNR--------KSQILKPN 525

  Fly   531 SVSNGHQIGIAVTADEEEQVKLENFK---------QRLKDELVTRDGHENLTKDTNIF-LRFKNP 585
            .:|  |::     .:|..::.:..||         :.||:|.|.|        |..|| :.||:.
  Fly   526 LLS--HEM-----REEFRKMPVGGFKFQFPWSRRERNLKNEKVER--------DLGIFCVAFKDK 575

  Fly   586 QLEQLYAVYREPY---SSLPL-----LAALLVQCI---DVLYSYLVLPRSTLHFINIAAPLVPIA 639
            .:|..| :::..|   .|:.|     ...:.:|.:   |:.|:.:|        |||.|..|...
  Fly   576 SVEWNY-LHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVV--------INIIAFFVLTF 631

  Fly   640 MLVVI---SLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIAL--TIGFSNVIDMFFFVTFVR 699
            :|.:.   .:....||.            |:.....:|:..|..|  .|..|.|:.:..::..:.
  Fly   632 LLFICWYKKVCWWHSGQ------------NEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIIL 684

  Fly   700 TEHIVSESEFNVTASLESD-INL-VVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVL 762
            ..::|...   :..|.|.| ..| ::|..:....:.|.:             ..:|...:|...|
  Fly   685 CYYMVISL---ILMSCEKDQYELDIIESKLYNYDMDPFT-------------CFHPWAYTNMMAL 733

  Fly   763 ILIAIAVIAQLTHLTKILLLLSIAALH----CYFNIFIMQDLYALEDDFEH----QPIISTRYAA 819
            ||......|::....|..:..:.|.:.    |:...||          |||    .|.:....|.
  Fly   734 ILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFI----------FEHSVTTSPYLKAEIAH 788

  Fly   820 SGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKN 884
            |..:.:..:.:....|..:...::.:|...::..::::|:...|....|:.|:||.||.|.::.:
  Fly   789 SCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSS 853

  Fly   885 TKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLE-LPQFQD 948
            ..:  .:||.::|..|.|:||.:.||          ...|..||.||::|:.||.||. ..|:..
  Fly   854 IAK--HELYYENYRMVSVMFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYV 906

  Fly   949 IIKIKTIGSTYMAASGINV----------------------QRTVRNDAPITERWSH---LAILV 988
            :.|||.:|.|||||.|::.                      |...|.::.|.|: :|   ..|:.
  Fly   907 VEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEK-NHDEVAFIMA 970

  Fly   989 EFALELKHALQSINE----QSFNHFV----LKMGINHGPITAGVIGARKPHYDIWGNTVNVASRM 1045
            .|||:|...|...|:    :.|:..:    :::||:.|.|.|||:||.:||||||||.||:||||
  Fly   971 TFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRM 1035

  Fly  1046 ESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYL 1090
            ||||.:|.||||:||...|..|......|||..|||:|::.|:::
  Fly  1036 ESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFV 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	35/191 (18%)
		CYCc	256..453	CDD:214485	85/217 (39%)
		Guanylate_cyc	294..476	CDD:278633	73/186 (39%)
		CYCc	860..1071	CDD:214485	87/244 (36%)
		Guanylate_cyc	892..1092	CDD:278633	87/232 (38%)
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	58/263 (22%)
		CYCc	262..464	CDD:214485	79/203 (39%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	73/193 (38%)
		CYCc	831..1055	CDD:214485	85/236 (36%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	87/231 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850