Protein Alignment Ac3 and NPR2

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_024303324.1
• Gene: NPR2 / 4882
• HGNCID: 7944
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1128
• Identity: 236/1128 - (20%)
• Similarity: 419/1128 - (37%)
• Gaps: 334/1128 - (29%)

  Fly   106 YLALTALLHIGRRSDKPALRRFHQILLIIVPRALW--LLSILHFTVYVILQPSFSPRDLLGWAIL 168
            :.|..|||::..|:|.    |.|...:..|..||.  .||:.| .||. .:|. .|.....:...
Human   162 WTARAALLYLDARTDD----RPHYFTIEGVFEALQGSNLSVQH-QVYA-REPG-GPEQATHFIRA 219

  Fly   169 LNFLVYVTLPLQL---IFL-----GLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAA 225
            ...:||:..||::   |.|     .|:.|...:|.   |.|   ..:||.:....|.
Human   220 NGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFY---LDV---FGESLRAGPTRAT-------- 270

  Fly   226 LIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAE----QERLLLSVLPKHVAIKMREDLGSS 286
              |..:......:|.:|..||.:::.|....|..:.|    |.|||         |:.|||.|..
Human   271 --GRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLL---------IRAREDFGVE 324

  Fly   287 SSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFAR----------FDRLAEK 341
            ...:...:......:..:|||:::..| |....:.:|.::::.::..|          .|:..::
Human   325 LGPSLMNLIAGCFYDGILLYAEVLNET-IQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDR 388

  Fly   342 YQQLRIKILGD---------CYYC---------------ISGAP----------------DERPD 366
            .....:..:||         .:|.               :.|||                |:.|.
Human   389 ETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPL 453

  Fly   367 HAVLCVHMGLSMVKAIKYVQQKANSPVDMRV--GIHTGAVLAGILGQRQWQFDVYSKDVELAN-K 428
            ..:..|.:|    ..|.::....:|.:..|.  .:.....||.:|.:.:|:      :::..| :
Human   454 STLAIVALG----TGITFIMFGVSSFLIFRPYRKLMLEKELASMLWRIRWE------ELQFGNSE 508

  Fly   429 MESSGKAGRVHISDK-----TLAFLNGEFEVEAAFG-------------EKREELLR-------- 467
            ....|...|:.:|.:     :|...:|::::.|..|             :||.||.|
Human   509 RYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKH 573

  Fly   468 IAGLKTYFITKVVKAFASPCAKKINETQAEIAHPN--------PNGSTTDIVSDEDDNDATLDDE 524
            :..::...:|:.:.|...|              ||        |.||..||:.::..|   ||
Human   574 MRDVQFNHLTRFIGACIDP--------------PNICIVTEYCPRGSLQDILENDSIN---LD-- 619

  Fly   525 ELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDG---HENLTKDTNIFLRFKNPQ 586
             .:.:.|:.|....|:|.                |.:.:::..|   ..|...|:...|:..:..
Human   620 -WMFRYSLINDLVKGMAF----------------LHNSIISSHGSLKSSNCVVDSRFVLKITDYG 667

  Fly   587 L------------EQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLP-----RSTLHFINI--- 631
            |            ..|||....|::.|.:|              |:.|     |......||
Human   668 LASFRSTAEPDDSHALYASEAHPHNPLFIL--------------LLFPPRDGGRGRWSDSNIGMS 718

  Fly   632 -----AAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDM 691
                 .||               |.|..|..|:...|.:.    ..||.:.....|.|.... |:
Human   719 PGGLGGAP---------------FRGTWPAGFLFSEKLWT----APELLSGNPLPTTGMQKA-DV 763

  Fly   692 FFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLY-PSY 755
            :.| ..:..|..:....|            .:||:    .|.|...|:::|:.   :|..: ||
Human   764 YSF-GIILQEIALRSGPF------------YLEGL----DLSPKEIVQKVRNG---QRPYFRPS- 807

  Fly   756 LSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALE----DDFEHQPIISTR 816
                           ...|.|.:.|:||             |:..:|.:    .||........|
Human   808 ---------------IDRTQLNEELVLL-------------MERCWAQDPAERPDFGQIKGFIRR 844

  Fly   817 YAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHF 881
            :...|...:....|..:.::.::.:::       |.|:.:...:.:::.|||:|.:||..|||..
Human   845 FNKEGGTSILDNLLLRMEQYANNLEKL-------VEERTQAYLEEKRKAEALLYQILPHSVAEQL 902

  Fly   882 MKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQF 946
            .:.     :.:.::::..|.:.|:.:..|:...:|.|    .::.:..||::.:.|||:::  .|
Human   903 KRG-----ETVQAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAIID--NF 956

  Fly   947 QDIIKIKTIGSTYMAASGI---NVQRTVRNDAPITERWSHLAILVEFALELKHALQS--INEQSF 1006
             |:.|::|||..||..||:   |.||             |...:...||.|..|:.|  |..:..
Human   957 -DVYKVETIGDAYMVVSGLPGRNGQR-------------HAPEIARMALALLDAVSSFRIRHRPH 1007

  Fly  1007 NHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTF 1071
            :...|::|::.||:.|||:|.:.|.|.::|:|||.||||||.|:|..|.|:..|.:.|...|...
Human  1008 DQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQ 1072

  Fly  1072 LQ-RGLVAVKGKGQLMTFYLQGK 1093
            |: ||.|.:||||::.|::|.|:
Human  1073 LELRGDVEMKGKGKMRTYWLLGE 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	41/171 (24%)
		CYCc	256..453	CDD:214485	42/258 (16%)
		Guanylate_cyc	294..476	CDD:278633	38/260 (15%)
		CYCc	860..1071	CDD:214485	66/215 (31%)
		Guanylate_cyc	892..1092	CDD:278633	67/205 (33%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556	60/291 (21%)
		PK_GC-A_B	521..848	CDD:270944	78/445 (18%)
		HNOBA	<857..902	CDD:311573	12/51 (24%)
		CYCc	881..1065	CDD:214485	64/208 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810