DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and NPR1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_000897.3	Gene:	NPR1 / 4881	HGNCID:	7943	Length:	1061	Species:	Homo sapiens

Alignment Length:	1204	Identity:	262/1204 - (21%)
Similarity:	428/1204 - (35%)	Gaps:	378/1204 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KPALRRFHQILLIIVPRALWLLSILH---FTVYVIL-----------------------QPSFSP 159
            :||..|...:||:::|..|.||...|   .||.|:|                       |....|
Human     6 RPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARP 70

  Fly   160 RDLLGWAI---------LLNFLVYVTLPL----------QLIFLGLSIGCITYFICLSLPVG--Y 203
            ..|.||.:         .|........||          ..:|||  .||    :..:.|||  .
Human    71 DLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLG--PGC----VYAAAPVGRFT 129

  Fly   204 SHWDSLLSNQLAANAVLIA-----------------------TAAL---IG------LLY-YFMG 235
            :||...|   |.|.|..:.                       .|||   :|      :|| |..|
Human   130 AHWRVPL---LTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPG 191

  Fly   236 EAKQ-----KRAFLEAKKSLEV---KMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFK 292
            :.:.     :..|:..:..|.:   .:...|........||..:|:    |.|.....||.:||:
Human   192 DEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPR----KGRVIYICSSPDAFR 252

  Fly   293 KIYMSR------HENVSILYADIVG----------------------------FTAIS-STYSAQ 322
            .:.:..      .|:....:.||.|                            |.|.. .||...
Human   253 TLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDP 317

  Fly   323 DLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQ 387
            |..:.| |...:...||  |:|....:.......|..:           .|.||     :.|:|.
Human   318 DNPEYL-EFLKQLKHLA--YEQFNFTMEDGLVNTIPAS-----------FHDGL-----LLYIQA 363

  Fly   388 KANSPVDMRVGIHTGAVLAG-ILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFL--- 448
            ...:..      |.|.|..| .:.||.|..........|  |::|||        |:...|.
Human   364 VTETLA------HGGTVTDGENITQRMWNRSFQGVTGYL--KIDSSG--------DRETDFSLWD 412

  Fly   449 ----NGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPN----G 505
                ||.|.|...:....:||:.::|                  :|:|   ..:.:|.|:    |
Human   413 MDPENGAFRVVLNYNGTSQELVAVSG------------------RKLN---WPLGYPPPDIPKCG 456

  Fly   506 STTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTA-------DEEEQVKLENFKQRLKD-- 561
            ...:..:...|:.:||:...|:...|:     :||.:.:       ..|:::..|.::.|.:|
Human   457 FDNEDPACNQDHLSTLEVLALVGSLSL-----LGILIVSFFIYRKMQLEKELASELWRVRWEDVE 516

  Fly   562 -------------------------ELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSL 601
                                     .|:|.:|...:...|..:       ...|.||.|.....:
Human   517 PSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYY-------KGNLVAVKRVNRKRI 574

  Fly   602 PLLAALLVQ---CIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSK 663
            .|...:|.:   ..||...:|.      .|:........|.:|.......|...:|....:.:..
Human   575 ELTRKVLFELKHMRDVQNEHLT------RFVGACTDPPNICILTEYCPRGSLQDILENESITLDW 633

  Fly   664 RF-----NDIT----FVRELAAIIIALTIGFSN-VIDMFFFVTFVRTEHIVSESEFNVTASLES- 717
            .|     |||.    |:.. .||.....:..|| |:|..|.:..  |::           .|||
Human   634 MFRYSLTNDIVKGMLFLHN-GAICSHGNLKSSNCVVDGRFVLKI--TDY-----------GLESF 684

  Fly   718 -DINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAV------------ 769
             |::......|.|:.|..|.  |.:|.|.|..|......:.:||: ||..||:
Human   685 RDLDPEQGHTVYAKKLWTAP--ELLRMASPPVRGSQAGDVYSFGI-ILQEIALRSGVFHVEGLDL 746

  Fly   770 --------------------IAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIIS 814
                                :|..:||.::.||              ||..:| ||..|..|...
Human   747 SPKEIIERVTRGEQPPFRPSLALQSHLEELGLL--------------MQRCWA-EDPQERPPFQQ 796

  Fly   815 TRYA--------ASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYN 871
            .|..        :|.:|   ...||.:.::.::.:.:       |.|:.:...:.:::.|||:|.
Human   797 IRLTLRKFNRENSSNIL---DNLLSRMEQYANNLEEL-------VEERTQAYLEEKRKAEALLYQ 851

  Fly   872 VLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISD 936
            :||..|||...:.     :.:.::::..|.:.|:.:..|:...:|.|    .::.:..||::.:.
Human   852 ILPHSVAEQLKRG-----ETVQAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTC 907

  Fly   937 FDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQS- 1000
            |||:::  .| |:.|::|||..||..||:          |:.....|...:...||.|..|::|
Human   908 FDAVID--NF-DVYKVETIGDAYMVVSGL----------PVRNGRLHACEVARMALALLDAVRSF 959

  Fly  1001 -INEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNIL 1064
             |..:......|::||:.||:.|||:|.:.|.|.::|:|||.||||||.|:|..|.::.||..:|
Human   960 RIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024

  Fly  1065 RLFGYTFLQ-RGLVAVKGKGQLMTFYLQGKSQSS 1097
            ..||...|: ||.|.:||||::.|::|.|:..||
Human  1025 EEFGGFELELRGDVEMKGKGKVRTYWLLGERGSS 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	49/245 (20%)
		CYCc	256..453	CDD:214485	47/239 (20%)
		Guanylate_cyc	294..476	CDD:278633	42/224 (19%)
		CYCc	860..1071	CDD:214485	66/212 (31%)
		Guanylate_cyc	892..1092	CDD:278633	67/202 (33%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380	90/475 (19%)
		ANF_receptor	54..414	CDD:279440	77/407 (19%)
		PK_GC-A_B	534..807	CDD:270944	63/317 (20%)
		TyrKc	547..801	CDD:197581	61/298 (20%)
		HNOBA	<816..861	CDD:285003	13/51 (25%)
		CYCc	840..1032	CDD:214485	66/213 (31%)
		Guanylate_cyc	867..1053	CDD:278633	67/202 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810