Protein Alignment Ac3 and Ac3

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_061511365.1
• Gene: Ac3 / 4578014
• VectorBaseID: AGAMI1_012876
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 1110
• Identity: 676/1110 - (60%)
• Similarity: 810/1110 - (72%)
• Gaps: 62/1110 - (5%)

  Fly    32 DSDVAGGVGI--TGGGVVILPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAP 94
            |..:|..|||  :|.|.|:||..||::||.:|::||:|.....::.|:.||::|.|.:|..||..
Mosquito     2 DGTMATTVGINQSGTGGVLLPDAVLDKLYQSYALKQKRVAFACYLIASILFDVWAIAVPQGQSVE 66

  Fly    95 TRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSP 159
            :.|:....|...:.|..:|....|.      ||..::..|.|...|||:|....:.:.|:.|.:|
Mosquito    67 SIVVTSVFLTINIVLAIVLRFCGRG------RFRGVIWEIAPHLAWLLAIKQLFLQLFLKGSVTP 125

  Fly   160 RDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATA 224
            ||.||||:|||||||||||:.|.:.|:.:|..::...::..:|.:..::....|..||.:|:..|
Mosquito   126 RDSLGWAVLLNFLVYVTLPVLLKYTGILLGLGSFATYVNAIIGLAKKENYFWEQQVANILLLIAA 190

  Fly   225 ALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE 289
            .|||||.||:.||||:|||||||:.|||||:|||||||||||||||||:|||:|||:||||::||
Mosquito   191 TLIGLLCYFLAEAKQRRAFLEAKQGLEVKMLIEEQSAEQERLLLSVLPEHVAVKMRQDLGSTNSE 255

  Fly   290 AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCY 354
            .||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||
Mosquito   256 QFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKILNELFARFDRLAEKYQQLRIKILGDCY 320

  Fly   355 YCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVY 419
            |||||||.||||||||||||||||||||||||||.||||||||||||||||||||||||||||||
Mosquito   321 YCISGAPVERPDHAVLCVHMGLSMVKAIKYVQQKTNSPVDMRVGIHTGAVLAGILGQRQWQFDVY 385

  Fly   420 SKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFA 484
            ||||||||||||||||||||:|:|||.|||||||||.||||||||.||||||||||||||:|.|
Mosquito   386 SKDVELANKMESSGKAGRVHLSEKTLGFLNGEFEVEPAFGEKREEALRIAGLKTYFITKVLKPF- 449

  Fly   485 SPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATL--DDEELLAQNSVSNGHQIGIAVTAD-- 545
              |..:         |.|.:....|:|.:.|.....|  ||::....|..:.|.:.....|.|
Mosquito   450 --CPSE---------HKNGSADPKDVVIEPDGPSEILREDDDDTKPANGANAGDEPSTPGTDDKT 503

  Fly   546 ---EEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAAL 607
               |::....|::|.||:.|||:||||..::|||.|||.|.:...|..|..||||:|::||||||
Mosquito   504 DPLEDDTQASEDYKMRLRKELVSRDGHSEISKDTTIFLTFNDKTHETAYNEYREPHSAVPLLAAL 568

  Fly   608 LVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVR 672
            |||.:.:||:.|||||:.:||..:..|||.|.::|.||:|||.:|:||.|....|||:||.|.:|
Mosquito   569 LVQFVAILYALLVLPRTAVHFEIVIPPLVIIFVMVFISVAESLTGILPAFITLNSKRYNDSTSLR 633

  Fly   673 ELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASF 737
            :..||||.|.:|.|||.||                   :.||..:.::|         ::...||
Mosquito   634 KSTAIIIVLLLGVSNVSDM-------------------LAASHRTPLSL---------NITNVSF 670

  Fly   738 VEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYA 802
            ..  .:..|....|:|||.||:.||||||.::|.||:||:||||::.|.|:|||.|||.:.:.:.
Mosquito   671 AS--TEMEPASVCLFPSYFSNYTVLILIATSIITQLSHLSKILLMIIITAIHCYVNIFHLDEAFR 733

  Fly   803 LEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEA 867
             .:||....:...||..|.||:...:|||.||||:|..|||||.|||||.:|||.|:|||:||||
Mosquito   734 -NEDFGIMNVFPLRYTLSALLVAVTIALSFLARHIDKVDRVIFMWKTEVIDQKEKASDMRRRNEA 797

  Fly   868 LVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNE 932
            |||||||:|||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   798 LVYNVLPMHVAEHFMGNRKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNE 862

  Fly   933 VISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHA 997
            ||||||||||||||||||||||||||||||||:|..|.|:.|.|::.||:|||:|||||||||.|
Mosquito   863 VISDFDALLELPQFQDIIKIKTIGSTYMAASGLNPSRIVKPDDPVSVRWAHLALLVEFALELKKA 927

  Fly   998 LQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCN 1062
            ||.||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||.
Mosquito   928 LQGINEQSFNHFVLKMGVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCQ 992

  Fly  1063 ILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVESTSELEASDI 1127
            ||:.|||||.|||||||||||||||:|||||......|.||.::    |:.:|:|:..|::.|..
Mosquito   993 ILQTFGYTFEQRGLVAVKGKGQLMTYYLQGKVPRPTGPTASPIL----QNLTAMETVQEVDESKE 1053

  Fly  1128 KMPLL 1132
            ..|.|
Mosquito  1054 SPPAL 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	246/332 (74%)
		Guanylate_cyc	294..476	CDD:425528	173/181 (96%)
		Guanylate_cyc	892..1092	CDD:425528	179/199 (90%)
Ac3	XP_061511365.1	None