DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Gycbeta100B

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	973	Identity:	203/973 - (20%)
Similarity:	341/973 - (35%)	Gaps:	280/973 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 LLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHEN---VSILYADIVGFTAISSTYS-----AQ 322
            |.|.|| ||        .|....|..||..|...|.   |..:|.|.:.:..|.:...     |.
  Fly     9 LELLVL-KH--------FGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPAD 64

  Fly   323 DLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQ 387
            |::::..:.|..|                                   |...|..     |.:|.
  Fly    65 DILELFGKTFFEF-----------------------------------CQDSGYD-----KILQV 89

  Fly   388 KANSPVDMRVGI-----HTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHI---SDKT 444
            ...:|.|....:     |.|.:..|:   |...|....||.||.....|. :.|..||   ..|.
  Fly    90 LGATPRDFLQNLDALHDHLGTLYPGM---RAPSFRCTEKDGELLLHYYSE-RPGLEHIVIGIVKA 150

  Fly   445 LAF-LNG----------------EFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKIN 492
            :|. |:|                |.|.|.|...:.::||..|...|...:..|....|..|::.|
  Fly   151 VASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNN 215

  Fly   493 ETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQI------GIAVT-------- 543
            .      |...|||         :|:...::...:..|:.::|.||      .||::
  Fly   216 N------HNGSNGS---------NNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDS 265

  Fly   544 --ADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAA 606
              .|.:::.|.....:...|::...|..:.|.::.|:..:      .|:.|...|....:..|.
  Fly   266 FDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAK------SQVDAKKDEVPDDMEFLC- 323

  Fly   607 LLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIA--------------MLVVISLAESFSGMLPKF 657
                                     .|||:..|              .:.::...::.|.::|:.
  Fly   324 -------------------------EAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRV 363

  Fly   658 FVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLV 722
            ..:      :.:.:..:.||...|.:.|.|::                 |..|....|::.
  Fly   364 AEE------NCSLIEVVEAIRPHLQLNFENIL-----------------SHINTIYVLQTR---- 401

  Fly   723 VEGMVTAEHLLPASFVE---QMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLS 784
             :|.:::.|  ...|:.   ||.....|:|:|:..|.|            :..|..|||..|.:|
  Fly   402 -QGAMSSRH--EQRFLRLKGQMMYIPETDRILFQCYPS------------VMNLDDLTKKGLYIS 451

  Fly   785 IAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKT 849
            ...||     ...:||..|.:.||      ..|..:..|.:....|....|.::.|
  Fly   452 DVPLH-----DAARDLVLLSEKFE------AEYKLTKNLEMLTDKLQQTFRDLESE--------- 496

  Fly   850 EVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFY 914
                        :|:.:.|:|:|||..||     |..|....:..:.|..|.::|:.:..|..:.
  Fly   497 ------------KQKTDRLLYSVLPKSVA-----NELRHQRPVPPKRYDSVTLMFSGIVGFGQYC 544

  Fly   915 SEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITE 979
            :..|..:..::.::.|||:.:.||||.:..:..::.|::|:|..|||.||:.           ..
  Fly   545 AANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP-----------DH 598

  Fly   980 RWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASR 1044
            ...|...:...||::....:::...| |...:.:||:.|.:..||||.|.|.|.::|||||:.||
  Fly   599 CEDHAKCMARVALDMMDMAKNVKMGS-NPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSR 662

  Fly  1045 MESTGKAGAIQVTEETCNILRLF-----GYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASG 1104
            .|:||..|.|.|:|||..:|.:.     .:....||.|.:|||...|..:...::.||
  Fly   663 TETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSS------- 720

  Fly  1105 VVVLNGQDS---SAVESTSELEASDIKMPLLKMNGPEQSLEIDQDRSLRNDSAGQESVAECQS 1164
              :|.|..|   |.......|: |.:..|.....|....:.:...|     :||..||:...|
  Fly   721 --ILGGTSSTGGSGGGGNGSLD-SPLLQPATPTAGAATPIPVVAQR-----AAGHASVSRTSS 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	6/18 (33%)
		CYCc	256..453	CDD:214485	44/219 (20%)
		Guanylate_cyc	294..476	CDD:278633	41/214 (19%)
		CYCc	860..1071	CDD:214485	62/215 (29%)
		Guanylate_cyc	892..1092	CDD:278633	59/204 (29%)
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	43/207 (21%)
		HNOBA	326..516	CDD:285003	50/268 (19%)
		CYCc	496..688	CDD:214485	63/229 (28%)
		Guanylate_cyc	522..714	CDD:278633	59/203 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740