DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Adcy1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1119	Identity:	385/1119 - (34%)
Similarity:	579/1119 - (51%)	Gaps:	201/1119 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ALFNIWTIGIPWDQSAPTRVINCCMLLA-YLALTALLHIGRRSDKPALRR----FHQIL---LII 134
            |||..:|:.:  :|:|..:.:....||| .|||..||  |.....|.|.:    .|.||   |.:
Mouse    46 ALFRGYTLRL--EQAATLKALAVLSLLAGALALAELL--GAPGPAPGLAKGSHPVHCILFLALFV 106

  Fly   135 VP--RALWL--------LSILHFTVYVILQPSFS----PRDLLG------------WAILL-NFL 172
            |.  |:|.:        |::.....:.:|...|:    .|...|            |.:|| .|:
Mouse   107 VTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLLVTFV 171

  Fly   173 VYVTLPLQLIFLGLSIGCITYFICLSLPVGYSH---------------WDSLLSNQLAANAVLIA 222
            .|..||::.:   |:||       ..|.|..||               |     ..|.|||:|..
Mouse   172 SYALLPVRSL---LAIG-------FGLVVAASHLLVTAALVPAKRPRLW-----RTLGANALLFF 221

  Fly   223 TAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSS 287
            ...:.|:....:.|..|::|||:|:..:|.::.:|:::.:|||||:|:||::||::|:||.....
Mouse   222 GVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPP 286

  Fly   288 SEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGD 352
            ...|.|||:.||:|||||:|||||||.::|..:||:|||:|||||.:||.||.:....|||||||
Mouse   287 ERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGD 351

  Fly   353 CYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFD 417
            ||||:||....:.|||..||.|||.|:..|..|.:.....::||||:|||.||.|:||.|:||:|
Mouse   352 CYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYD 416

  Fly   418 VYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFIT----- 477
            |:|.||.|||.||::|..|:|||:..|||.|||::|||...|.:|...||...::|:||.
Mouse   417 VWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRR 481

  Fly   478 -----------KVVK--AFASPC--------AKKINETQAEIAHPNPNGSTTDIVSDEDDND--- 518
                       |..|  .|.:.|        .:|:  .:|||...|       :::.|||:.
Mouse   482 KIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKM--FKAEIPFSN-------VMTCEDDDKRRA 537

  Fly   519 ATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIF-LRF 582
            .....|:|..::|.|.    .:..|.   ...::..:..||.:...|    |....|.|.| |::
Mouse   538 LRTASEKLRNRSSFST----NVVYTT---PGTRVNRYISRLLEARQT----ELEMADLNFFTLKY 591

  Fly   583 KNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLA 647
            |:.:.||.|...::.|.:..::.||::..:..|...||:|:|           |.:.:|:|.|:.
Mouse   592 KHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYLLVIPQS-----------VAVLLLLVFSIC 645

  Fly   648 ESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVT 712
                      |:.....:..||.|:....   .|||.....:.:|..|.      |.|.::..|.
Mouse   646 ----------FLVACTLYLHITRVQCFPG---CLTIQIRTALCVFIVVL------IYSVAQGCVV 691

  Fly   713 ASL------ESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIA 771
            ..|      :|:.:|||........:||         |:|.|...:.......|.|   .:|:..
Mouse   692 GCLPWAWSSQSNSSLVVLAAGGRRTVLP---------ALPCESAHHALLCCLVGTL---PLAIFL 744

  Fly   772 QLTHLTKILLLLSIAALHCYFNIFIMQDLYALE------------DDFEHQPIISTRYAASGLLL 824
            :::.|.|::||..:...:          :..||            ....::||::.      ||.
Mouse   745 RVSSLPKMILLSGLTTSY----------ILVLELSGYTKVGGGALSGRSYEPIMAI------LLF 793

  Fly   825 VAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSH 889
            ...|||.  ||.:|...|:.:.|..:..|:::....::..|:.:::|:||.|||:||:.:..|:.
Mouse   794 SCTLALH--ARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNM 856

  Fly   890 DDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKT 954
             |||.|||::|||:|||:|||:|||.|...||.|:||||.|||:|:|||.|::...::|:.||||
Mouse   857 -DLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKT 920

  Fly   955 IGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGP 1019
            ||||||||.|:......|....|:   |||..|.:||:::...|..||.||:|.|||::|||.||
Mouse   921 IGSTYMAAVGLAPTAGTRAKKSIS---SHLCTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGP 982

  Fly  1020 ITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQ 1084
            :.|||||||:|.||||||||||||||:|||..|.||||||...:|:...|.|:.||.|:|||||:
Mouse   983 VVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGE 1047

  Fly  1085 LMTFYLQGKSQSSA 1098
            ::|::|:|::..::
Mouse  1048 MLTYFLEGRTDGNS 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	54/202 (27%)
		CYCc	256..453	CDD:214485	107/196 (55%)
		Guanylate_cyc	294..476	CDD:278633	99/181 (55%)
		CYCc	860..1071	CDD:214485	114/210 (54%)
		Guanylate_cyc	892..1092	CDD:278633	114/199 (57%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831	42/147 (29%)
		CYCc	257..452	CDD:214485	106/194 (55%)
		Guanylate_cyc	293..475	CDD:278633	99/181 (55%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		5/28 (18%)
		CYCc	825..1036	CDD:214485	115/214 (54%)
		Guanylate_cyc	858..1055	CDD:278633	114/199 (57%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710