Protein Alignment Ac3 and Ac76E

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Alignment Length: 1380
• Identity: 421/1380 - (30%)
• Similarity: 615/1380 - (44%)
• Gaps: 374/1380 - (27%)

  Fly     3 ANLENGQKTIAST------SKSHSQRQTTSRRRQNDSDVAGGVGIT--GGGVVILPQHVLNELYH 59
            |...||....|:.      :.:..:..|:|..|.||:..|....::  ..|......| ||:||.
  Fly     9 AKTGNGTNATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIH-LNDLYT 72

  Fly    60 NYSIKQR----RSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSD 120
            .|..:.|    ||||...:.|..:..|  |||.:.|              :|..|.||
  Fly    73 RYRQRLRKSLFRSGLLTSLLACVVSII--IGIVYGQ--------------HLVQTMLL------- 114

  Fly   121 KPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNF----LVYVT----- 176
                     :|..::..:  :|:.|.|...:     .||...|.:||:..|    :..:|
  Fly   115 ---------VLAALISGS--ILTALQFPAVL-----SSPAAALAFAIVTTFSLGTIAAITGDELA 163

  Fly   177 -LPLQLIFLGLSIGCITYFICLSLPVG---------------------YSHWDSLLSNQLAANAV 219
             ||:..:||     ||...:.:|.||.                     |:....:|..::    |
  Fly   164 PLPMYALFL-----CIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEI----V 219

  Fly   220 LIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL- 283
            ::|:|::.||.|..|.:|...|.....:..:|.::.:|.:..:||:|||||:|.::|.:::..:
  Fly   220 MLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIM 284

  Fly   284 -------------GSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARF 335
                         .|:|:..|.::::.||.||:||:||||.||.:||:.:|.||||.||:||.||
  Fly   285 LKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRF 349

  Fly   336 DRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIH 400
            |::|::.|.||||||||||||:||.|..||.||..||:|||.|:.||::|::.....||||:|||
  Fly   350 DQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIH 414

  Fly   401 TGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREEL 465
            ||.||.|:||.|:|||||:|.||.|||.|||.|.||||||:.:||.||..:||||...|..|:..
  Fly   415 TGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAY 479

  Fly   466 LRIAGLKTYFI-----------------------------TKVVK------------------AF 483
            |....:::|.|                             ||.:|                  ..
  Fly   480 LADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTV 544

  Fly   484 ASPCA--------KKINETQAEIAHPNPNGSTTDI--VSDEDD--NDATLDDEELLAQNS----- 531
            |.|.|        ..||..:|.:..|..:.::..|  :|:|:|  ::||...|.|:.::.
  Fly   545 APPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKND 609

  Fly   532 ---VSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNP-------- 585
               .:||...|...:|..|...|....... .|:|::..|.|:...::....:..||
  Fly   610 KEPKANGGHRGSGDSAASESVAKSAALSLP-ADDLLSMSGSESGISNSGAQAQSSNPASVTPTAA 673

  Fly   586 -----QLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRS----------TLH-------- 627
                 .......|...|..|...|:      :..|.|:....||          ::|
  Fly   674 APAGGAASNSLTVAEAPERSRRKLS------VQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSH 732

  Fly   628 -------------------------FINIA-APLVPIAMLVVISLAESFSGMLP--------KFF 658
                                     |.||| :.||....|..|::.|  |.:||        .||
  Fly   733 AGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIE--SNLLPPERKCFNFNFF 795

  Fly   659 -------------------------VDVSKRFNDI-TFVRELAAIIIALTIGFSNV--------- 688
                                     .|...||:.| .||..|:..::.|.:...|:
  Fly   796 GPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS 860

  Fly   689 ---IDMFFFVTFV--------RTE-----HIVSESEF---------NV---TASLESDINLVVEG 725
               :.:|.:::.:        .||     .:|:.|.:         |:   :.::.|.||..|..
  Fly   861 FVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPD 925

  Fly   726 MVTAEHLLPAS------------FVEQMRD---------AVPTERV-LY---------PSYLSNF 759
            .|:.|   |:|            ||....:         |:|...| ||         .::|.:.
  Fly   926 GVSKE---PSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSG 987

  Fly   760 GVLILIA--IAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGL 822
            .:|.|||  :|||||:|                   :....||:.:.:|......:........|
  Fly   988 FILKLIAMLVAVIAQVT-------------------VLGYSDLFEMYNDANITHGLPLEIKGFLL 1033

  Fly   823 LLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKR 887
            |||..|.|.||.|..::..|..|.||.::..::|....||..|:.|:.|:||.|||.||: :.:|
  Fly  1034 LLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFL-HLER 1097

  Fly   888 SHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKI 952
            | .:||.:||:.|.|:|||:||:.:||.|..||.|||||||.|||:|.|||.||..|:|..|.||
  Fly  1098 S-TELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKI 1161

  Fly   953 KTIGSTYMAASGINVQR----TVRN--DAPITERWSHLAILVEFALELKHALQSINEQSFNHFVL 1011
            |||.||||.|||:...:    |.|:  |...||. .::.||||||:.|...|.|||.:||..|.|
  Fly  1162 KTIASTYMCASGLRPGKEDGATSRSFADEKRTEE-HNVVILVEFAIALMSILDSINRESFQRFRL 1225

  Fly  1012 KMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGL 1076
            ::|:||||:.||||||:||.||||.|||||||||:|.|..|.:|.||.|..||...||....|||
  Fly  1226 RIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGL 1290

  Fly  1077 VAVKGKGQLMTFYLQ 1091
            ..|||||.|:|::::
  Fly  1291 TYVKGKGNLVTYFVK 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	143/377 (38%)
		Guanylate_cyc	294..476	CDD:425528	104/181 (57%)
		Guanylate_cyc	892..1092	CDD:425528	114/206 (55%)
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	160/445 (36%)
		Guanylate_cyc	310..469	CDD:425528	98/158 (62%)
		Guanylate_cyc	1101..1305	CDD:425528	114/204 (56%)