DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and CG43373

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster

Alignment Length:	1251	Identity:	412/1251 - (32%)
Similarity:	605/1251 - (48%)	Gaps:	213/1251 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KSHSQRQTTSRRRQNDSDVAGGVGITGGGV--VILPQHVLNELYHNYSIKQ---------RRSGL 70
            |||.|.:|..|.|:..|....|: :.|||:  .::.....::....|::..         |.:|.
  Fly   403 KSHQQHRTRYRMREKRSLQDAGL-VKGGGIQTQLIVDTATDDDADVYTVASDDDDDVDGGRSAGS 466

  Fly    71 KWFVFAAALFNIWTI---------------GIPWDQSAP------------------TRVINCCM 102
            |...:...:.:...|               |:..|.|.|                  ..|....|
  Fly   467 KHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVM 531

  Fly   103 LLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRA-LWLLSILHFTVYVILQPSFSPRDLLGWA 166
            |:..:....||.|   ..|||:   ::|.|::|... |.....:...|...:|||   :...|.|
  Fly   532 LICGIVYAFLLCI---LSKPAM---NEIFLVLVSYVILGTFLAIEVAVSYAMQPS---KSFNGSA 587

  Fly   167 --ILLNFLVYVTLPLQL---IFLGLSIGCITYFICLSL------PVGYSHWDSLLSNQLAANAVL 220
              |:|.::.|..|||:|   :..|:.:..:..:.||.|      .|...||:.||     ...|.
  Fly   588 CCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELL-----CTLVA 647

  Fly   221 IATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL-G 284
            :..|.|.|:..::..|..|::||:|.::.:|.::..:.::.:||||||||||:|||::|::|: |
  Fly   648 LLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAG 712

  Fly   285 SSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKI 349
            ......|.|||:.||||||||:|||.|||::|...:|::||::||||||||||||.::..||||:
  Fly   713 QPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 777

  Fly   350 LGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQW 414
            |||||||:||.|:.|||||...|.|||.|:.||..|::.....|:||||||||.|..|:||..:|
  Fly   778 LGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKW 842

  Fly   415 QFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKV 479
            ||||:|.||.|||.|||.|..|||||:.:||..|:|::|||...|.:|...|:...::||.|  |
  Fly   843 QFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLI--V 905

  Fly   480 VKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDE-------------------DDNDATLDDEE 525
            ......|..|..|..|.       ||:    :|.|                   |.:::..|.|
  Fly   906 PGDIYRPHKKSRNRLQV-------NGN----ISKELRMMGHGTAQKHTSKFGFGDSSESAKDPE- 958

  Fly   526 LLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQL 590
                               ||..:..:.....|..|.|  |..|     ..::.|.||:..||:.
  Fly   959 -------------------DEVNEYLMRAIDARSIDHL--RAEH-----CQSLLLCFKDNVLERK 997

  Fly   591 YAVYREP--------YSS-LPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISL 646
            ||  .||        |.| |.||...:::.:....|.|.|..||       ..|:.:..||.:..
  Fly   998 YA--SEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALST-------GALLLLGFLVFLVA 1053

  Fly   647 AESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNV 711
            ....:..||......|.|.:....:.:|.|......|..:.::.||            .||...:
  Fly  1054 CHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMF------------QESGRQM 1106

  Fly   712 TASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAI---AVIAQL 773
            .........|.|.|.::   |.......:|.||...:...|.:| :.|.:|.|:::   |....|
  Fly  1107 ELLQRRRFWLDVNGSIS---LNDTELNTKMYDAEEPDCDFYLAY-NTFLLLTLLSMMSCATYQVL 1167

  Fly   774 THLTKILLLL--SIAALHCYFNIF-----IMQDLYALEDDFEHQPIISTRYAASGLLLVA-ALAL 830
            ..|.|:||||  |.:.:.|..|::     :.|:| |.|:..       .||....:.|.| .|||
  Fly  1168 RILLKLLLLLLASGSYMACSSNLYSRSREMSQEL-ANEEAL-------LRYIIDSIFLFAFMLAL 1224

  Fly   831 STLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQ 895
            ...:...:...|:.|.||.:..|:||....::..|..|:.|:|||||||||:...|.. ||||.:
  Fly  1225 IFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHL-DDLYHE 1288

  Fly   896 SYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYM 960
            ....|.:||||:||||:||.|...||:|:||||.|||:|:|||.||...:|:.|.|||:.|:|||
  Fly  1289 QCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYM 1353

  Fly   961 AASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVI 1025
            ||||:......|      ..:||:..:.::||:|...::.:|..|||:|.:::|||.||:.||||
  Fly  1354 AASGLTANTCDR------VNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVI 1412

  Fly  1026 GARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYL 1090
            ||.||.||||||.|||||||:|||....||||:|...||...|:....||.|.|||||.::|::|
  Fly  1413 GACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477

  Fly  1091 QGK----------SQSSAEP------------VASGVVVLNGQDSSAVESTSELEASDIKMPLLK 1133
            :|:          :::..||            :.||......::....:.::|.|...:..|.:.
  Fly  1478 KGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDID 1542

  Fly  1134 MNGPEQSLEIDQDRSL 1149
            ||...|:|...:.:||
  Fly  1543 MNSNMQNLTAQRRKSL 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	51/170 (30%)
		CYCc	256..453	CDD:214485	114/197 (58%)
		Guanylate_cyc	294..476	CDD:278633	104/181 (57%)
		CYCc	860..1071	CDD:214485	106/210 (50%)
		Guanylate_cyc	892..1092	CDD:278633	101/199 (51%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	61/210 (29%)
		CYCc	686..881	CDD:214485	114/194 (59%)
		Guanylate_cyc	722..895	CDD:278633	101/172 (59%)
		DUF1053	<949..1005	CDD:283888	19/84 (23%)
		CYCc	1259..1455	CDD:214485	105/202 (52%)
		Guanylate_cyc	1285..1479	CDD:278633	101/199 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750