DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and ACXD

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster

Alignment Length:	1299	Identity:	321/1299 - (24%)
Similarity:	558/1299 - (42%)	Gaps:	372/1299 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EANLENGQKTIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGGVVILPQHVLN-ELYHNYSIKQ 65
            ::.:|..:....|.:::.||.||.    ||:.:....         .|.:...| ||..:|.:..
  Fly     6 DSAIEYNRSNPISLARTSSQAQTV----QNEKNWEWS---------YLVRKCRNLELEDSYDLYM 57

  Fly    66 RRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQI 130
            ||                                  :.:.||:|...:|:       |:...|.:
  Fly    58 RR----------------------------------LRVGYLSLFIFIHV-------AVTVIHTL 81

  Fly   131 LLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAIL-LNF----------LVYVT-----LPL 179
            ||:..|...:        |||.: .::....|:.|.:| :||          :||.|     ..:
  Fly    82 LLLTTPEIKY--------VYVDM-VAYMCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVM 137

  Fly   180 QLIFLGLSIGCIT---------------YFICLSLPVGYSHWDSLL------------------- 210
            .|:.:||::...|               |.|.:.:||.|.....:|
  Fly   138 VLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAK 202

  Fly   211 -SNQLAA---NAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVL 271
             .||:.:   .|:.::...|:|:.:..|.:...:..||:.::.:|..:::.....::..||||:|
  Fly   203 DDNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSIL 267

  Fly   272 PKHVAIKMREDL--------------------GSSSSEAFKK--------IYMSRHENVSILYAD 308
            |..:|.:::||:                    .|:.|:..|:        :::..||:|::||||
  Fly   268 PAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYAD 332

  Fly   309 IVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVH 373
            :|.:|.:::|...:.||:.|::||.|||..:|:|..||||.|||||||::|..:...|||..||.
  Fly   333 VVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVD 397

  Fly   374 MGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRV 438
            :||.|:|.|:.|::|.:..:|||:|:|:|.||:|::|..:||||::||||::||::|::|..|||
  Fly   398 LGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRV 462

  Fly   439 HISDKTLAFLNGEFEVEAAFGEKREE-LLRIAGLKTYFITKVVKAFASPC-----------AKKI 491
            |:|.|||:.|:||:..|....:.||: :|:..|::|:    ::|:..:|.           .||:
  Fly   463 HVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTF----LIKSLRAPMHDPRRRMRERQVKKL 523

  Fly   492 NE-TQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENF 555
            :| ::|...|                 ::||..     .|.|.|..::.:....|:....:::..
  Fly   524 SEASKANFMH-----------------NSTLHQ-----YNQVRNQAKLEMCRELDKMPIGRIQLT 566

  Fly   556 KQRLKDELVTRDGHENLTKDTNI-----FLRFKNPQLEQLYAVYREP-----YSS----LPLLAA 606
            |...:...:|:|..|..|...||     |.|.:|.:.:.:    :||     ||.    :..:..
  Fly   567 KVFRRSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQYI----KEPDVMLKYSIALAWVIYMGL 627

  Fly   607 LLVQCI--DVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISL-------------AESFSGMLPK 656
            |.:|.:  |..|.|..:..:|         ::.:.||:::|.             ..|.:|.|..
  Fly   628 LTIQLLSKDARYHYWYIDGTT---------IILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSG 683

  Fly   657 FFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINL 721
            |...:|........:|                :.|:|.:.|          .:...|.::
  Fly   684 FLFRMSDEMQRNVVIR----------------VVMYFLIIF----------SYCAVAIMQ----- 717

  Fly   722 VVEGMVTAEHLLPASFVEQMRDAVPT--ERV--LYPSYLSNFGVLILIAIAVIAQLTHLTK---- 778
                      ::..|..|...|..||  |||  .:|..|:|...|::....:..::..:.|
  Fly   718 ----------VVGCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMSFLFTRIPFIIKSCFS 772

  Fly   779 ILLLLSIAAL-HCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDR 842
            .|:::..|.| ...|| ||..:..:...:|      :.:|:...|:::.......:.|..:...:
  Fly   773 ALIMIGYAVLVVSEFN-FIYANSPSTNVNF------NAKYSHILLMIITFGIFHLMERQTEFIAK 830

  Fly   843 VIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASM 907
            |.:.||.::.:::|.|.......:.|:.|:||.|||:.::.|  :..::||.:.|..|.|:|||:
  Fly   831 VDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSN--QLQNELYYEEYDNVAVMFASI 893

  Fly   908 PNFSDFYSEETVNNQGLECLRFLNEVISDFDALL-ELPQFQDIIKIKTIGSTYMAASGINVQRTV 971
            .||.       .:..|   ||.|||:|.|||.:| :..|...:.|||....|||||.|::|.|:.
  Fly   894 KNFD-------TDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSE 948

  Fly   972 RNDAP--------------------------------------------ITERWSH--------- 983
            :.:||                                            ..||..:
  Fly   949 QVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGP 1013

  Fly   984 --------------LAILVEFALELKHALQSIN--------EQSFNHFVLKMGINHGPITAGVIG 1026
                          :.::.||||:|...::..|        |.|.::.:|::||:||...|||:|
  Fly  1014 RISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVG 1078

  Fly  1027 ARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYL 1090
            ..|||||||||.||:||||:|||..|.|||||.|...||.|......||:..|||:|.:.|:.:
  Fly  1079 ISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	43/231 (19%)
		CYCc	256..453	CDD:214485	89/224 (40%)
		Guanylate_cyc	294..476	CDD:278633	83/182 (46%)
		CYCc	860..1071	CDD:214485	90/286 (31%)
		Guanylate_cyc	892..1092	CDD:278633	89/275 (32%)
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	54/291 (19%)
		CYCc	254..476	CDD:214485	88/221 (40%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	83/185 (45%)
		CYCc	856..1117	CDD:214485	87/272 (32%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	89/273 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850