Protein Alignment Ac3 and Adcy1

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001100709.1
• Gene: Adcy1 / 305509
• RGDID: 1309318
• Length: 967
• Species: Rattus norvegicus
• Alignment Length: 1002
• Identity: 357/1002 - (35%)
• Similarity: 537/1002 - (53%)
• Gaps: 171/1002 - (17%)

  Fly   165 WAILL-NFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSH---------------WDSLLSNQ 213
            |.:|| .|:.|..||::.:   |:||       ..|.|..||               |     ..
  Rat    11 WQLLLVTFVSYALLPVRSL---LAIG-------FGLVVAASHLLVTAALVPAKRPRLW-----RT 60

  Fly   214 LAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIK 278
            |.|||:|.....:.|:....:.|..|::|||:|:..:|.::.:|:::.:|||||:|:||::||::
  Rat    61 LGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAME 125

  Fly   279 MREDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQ 343
            |:||........|.|||:.||:|||||:|||||||.::|..:||:|||:|||||.:||.||.:..
  Rat   126 MKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENH 190

  Fly   344 QLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGI 408
            ..|||||||||||:||....:.|||..||.|||.|:..|..|.:.....::||||:|||.||.|:
  Rat   191 CRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGV 255

  Fly   409 LGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKT 473
            ||.|:||:||:|.||.|||.||::|..|:|||:..|||.|||::|||...|.:|...||...::|
  Rat   256 LGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIET 320

  Fly   474 YFIT----------------KVVK--AFASPC--------AKKINETQAEIAHPNPNGSTTDIVS 512
            :||.                |..|  .|.:.|        .:|:  .:|||...|       :::
  Rat   321 FFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKM--FKAEIPFSN-------VMT 376

  Fly   513 DEDDND---ATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTK 574
            .|||:.   .....|:|..::|.|.    .:..|.   ...::..:..||.:...|    |....
  Rat   377 CEDDDKRRALRTASEKLRNRSSFST----NVVYTT---PGTRVNRYISRLLEARQT----ELEMA 430

  Fly   575 DTNIF-LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPI 638
            |.|.| |::|:.:.||.|...::.|.:..::.||::..:..|...||:|:|           |.:
  Rat   431 DLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQS-----------VAV 484

  Fly   639 AMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHI 703
            .:|:|.|:.          |:.....:..||.|:....   .|||.....:.:|..|.      |
  Rat   485 LLLLVFSIC----------FLVACTLYLHITRVQCFPG---CLTIQIRTALCVFIVVL------I 530

  Fly   704 VSESEFNVTASL------ESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVL 762
            .|.::..|.:.|      .|:.:|||........:||         |:|.|.       ::.|:|
  Rat   531 YSVAQGCVVSCLPWAWSSHSNSSLVVLAAGGRRTVLP---------ALPCES-------AHHGLL 579

  Fly   763 ILIA----IAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALE------------DDFEHQP 811
            ..:.    :|:..:::.|.|::||..:...:          :..||            ....::|
  Rat   580 CCLVGTLPLAIFLRVSSLPKMILLSGLTTSY----------ILVLELSGYTKVGGGALSGRSYEP 634

  Fly   812 IISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVH 876
            |::.      ||....|||.  ||.:|...|:.:.|..:..|:::....::..|:.:::|:||.|
  Rat   635 IMAI------LLFSCTLALH--ARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAH 691

  Fly   877 VAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALL 941
            ||:||:.:..|:. |||.|||::|||:|||:|||:|||.|...||.|:||||.|||:|:|||.|:
  Rat   692 VAQHFLMSNPRNM-DLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELM 755

  Fly   942 ELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSF 1006
            :...::|:.||||||||||||.|:......|....|:   |||:.|.:||:::...|..||.||:
  Rat   756 DKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSIS---SHLSTLADFAIDMFDVLDEINYQSY 817

  Fly  1007 NHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTF 1071
            |.|||::|||.||:.|||||||:|.||||||||||||||:|||..|.||||||...:|....|.|
  Rat   818 NDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRCSYQF 882

  Fly  1072 LQRGLVAVKGKGQLMTFYLQGKSQSSA 1098
            :.||.|:|||||:::|::|:|::..|:
  Rat   883 VCRGKVSVKGKGEMLTYFLEGRTDGSS 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	136/305 (45%)
		Guanylate_cyc	294..476	CDD:425528	99/181 (55%)
		Guanylate_cyc	892..1092	CDD:425528	114/199 (57%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:318454	42/142 (30%)
		Guanylate_cyc	141..323	CDD:425528	99/181 (55%)
		Guanylate_cyc	706..903	CDD:425528	114/199 (57%)