DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and GUCY2D

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	255	Identity:	80/255 - (31%)
Similarity:	121/255 - (47%)	Gaps:	42/255 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   851 VAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYS 915
            :.|:.|.....:|:.:.|:..:||..|||.....|.      ....|.|...|:     |||...
Human   835 IRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP------VEPEYFEQVTLY-----FSDIVG 888

  Fly   916 EETVN--NQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGI---NVQRTVRNDA 975
            ..|::  ::.:|.:..||::.:.|||::   ...|:.|::|||..||.|||:   |.||
Human   889 FTTISAMSEPIEVVDLLNDLYTLFDAII---GSHDVYKVETIGDAYMVASGLPQRNGQR------ 944

  Fly   976 PITERWSHLAILVEFALELKHALQSINEQSFNHFV-----LKMGINHGPITAGVIGARKPHYDIW 1035
                   |.|.:...:|::   |.::......|..     :::|::.||..|||:|...|.|.::
Human   945 -------HAAEIANMSLDI---LSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLF 999

  Fly  1036 GNTVNVASRMESTGKAGAIQVTEETCNILRLF--GYTFLQRGLVAVKGKGQLMTFYLQGK 1093
            |:|||.||||||||....|.|...|..|||..  ||....||...:||||...||:|.|:
Human  1000 GDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGR 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		CYCc	860..1071	CDD:214485	68/222 (31%)
		Guanylate_cyc	892..1092	CDD:278633	69/211 (33%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945
		HNOBA	<820..865	CDD:369471	9/29 (31%)
		CYCc	846..1036	CDD:214485	67/219 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810