DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac3 and GUCY2F

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_001513.2 Gene:GUCY2F / 2986 HGNCID:4691 Length:1108 Species:Homo sapiens


Alignment Length:1231 Identity:249/1231 - (20%)
Similarity:407/1231 - (33%) Gaps:449/1231 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 LSILHFTVYVILQPSFSPRDLLG----------WAILLNFLVYVTLPLQLIFLGLSIGCITYFIC 196
            |.:..|:..|:...:|  |.|||          |.:.|  |..::||.|:..|...||.:..:.|
Human     3 LGLGRFSRLVLWFAAF--RKLLGHHGLASAKFLWCLCL--LSVMSLPQQVWTLPYKIGVVGPWAC 63

  Fly   197 LSLPVGYSHWDSLLSNQLAANAVLIATAAL-----IGLLYYFMGEAKQKRAFLEAKKSLEVKMVI 256
                      |||.|..|...|..:|...:     ..|.|.|                   :.||
Human    64 ----------DSLFSKALPEVAARLAIERINRDPSFDLSYSF-------------------EYVI 99

  Fly   257 EEQSAEQERLLLSVLPKHVAIKMRED---------------LGSS-------------------S 287
            ..:..:..|.|.|.:..|   :|...               ||:|                   |
Human   100 LNEDCQTSRALSSFISHH---QMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKIS 161

  Fly   288 SEAFK--------------KIYMSRHENVSILYADIVGFTA-----------------ISSTYSA 321
            ...|.              |.:...|..|.....||...||                 :::...:
Human   162 YPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDS 226

  Fly   322 QDLVKMLNELFARFDRLAEKYQQLRIKILGDCYY--CISGAPDERPDHAVLCVHMGLSMV----- 379
            |.:.|.|..:          :|..||:|:..|.:  .|.|   |...|.:.|.| .|.|.     
Human   227 QSMRKALQRI----------HQADRIRIIIMCMHSALIGG---ETQMHLLECAH-DLKMTDGTYV 277

  Fly   380 ----KAIKYVQQKANSP-------------VDMRVGI------------HTGAVLAGILGQRQWQ 415
                .|:.|.....::|             .|..:.|            .|.|...|.:.:: .:
Human   278 FVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEK-LE 341

  Fly   416 FD--------VYSKDVELA----NKMESSGKAGRVHI--SDKTLAF----------LNG------ 450
            ||        :|:....:|    |.|:.:|:||...:  ..:.:.|          .||      
Human   342 FDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEY 406

  Fly   451 --------EFEVEAAFGEKRE-ELLRIAGLKTYF------------------------------- 475
                    |:|:.:.:....| ||||..|...:|                               
Human   407 VILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMM 471

  Fly   476 --ITKV-----VKAFASPCAKKINETQ------------AEIAHPNPN-----GSTTDI---VSD 513
              :|.:     :..||....::||:.|            .::...||:     ||...:   ::.
Human   472 VCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITS 536

  Fly   514 EDDNDATLDDEELLAQNSVSNG-------HQIGIAVTADEEEQVK---------LENFKQRLKD- 561
            |..:..:       .:.|.|:|       ....||:...:...:|         |::.|.|..| 
Human   537 EVQSGRS-------PRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDV 594

  Fly   562 -ELVTRDGHENLTKDTNIFLRFKNPQL-----EQLYAVYREPYSSLPLLAALLVQCIDVLYSYLV 620
             |::....|||:           ||.|     ..::|:..|..|...|...|..|  ||...::.
Human   595 FEMMKDLRHENI-----------NPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQ--DVKLDWMF 646

  Fly   621 LPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGF 685
              :|:| .:::      |..:..:...|...|.|......|..||           ::.....||
Human   647 --KSSL-LLDL------IKGMKYLHHREFVHGRLKSRNCVVDGRF-----------VLKVTDYGF 691

  Fly   686 SNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERV 750
            :::::|.          .:||.|    :|:|       |.:.||..||               |.
Human   692 NDILEML----------RLSEEE----SSME-------ELLWTAPELL---------------RA 720

  Fly   751 LYPSYLSNF-GVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALE-------DDF 807
            ...|.|.:| |.:...||.:...:...|.                |.|.||.|.|       ...
Human   721 PRGSRLGSFAGDVYSFAIIMQEVMVRGTP----------------FCMMDLPAQEIINRLKKPPP 769

  Fly   808 EHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKT----------------------- 849
            .::|::...:|....|.:.....:..|......|.:..::||                       
Human   770 VYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSN 834

  Fly   850 ---EVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFS 911
               .:.|:.|.....:|:.|.|:..:||..|||...|......:..      ::..|:     ||
Human   835 LEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF------DLVTLY-----FS 888

  Fly   912 DFYSEETVN--NQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRND 974
            |.....|::  ::.:|.:..||::.:.|||::   ...|:.|::|||..||.|||:..:...|  
Human   889 DIVGFTTISAMSEPIEVVDLLNDLYTLFDAII---GSHDVYKVETIGDAYMVASGLPKRNGSR-- 948

  Fly   975 APITERWSHLAILVEFALELKHALQSINEQSFNHFV-----LKMGINHGPITAGVIGARKPHYDI 1034
                    |.|.:...:|::   |.|:......|..     :::|::.||:.|||:|...|.|.:
Human   949 --------HAAEIANMSLDI---LSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCL 1002

  Fly  1035 WGNTVNVASRMESTGKAGAIQVTEETCNILRLF--GYTFLQRGLVAVKGKGQLMTFYLQGK 1093
            :|:|||.||||||||....|.|:..|..||:..  ||....||...:||||...||:|.||
Human  1003 FGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 36/172 (21%)
CYCc 256..453 CDD:214485 55/335 (16%)
Guanylate_cyc 294..476 CDD:278633 51/306 (17%)
CYCc 860..1071 CDD:214485 65/219 (30%)
Guanylate_cyc 892..1092 CDD:278633 65/208 (31%)
GUCY2FNP_001513.2 PBP1_sensory_GC_DEF_like 54..435 CDD:107366 75/427 (18%)
ANF_receptor 75..412 CDD:279440 60/373 (16%)
PKc_like 545..815 CDD:304357 68/354 (19%)
HNOBA <824..869 CDD:285003 10/44 (23%)
CYCc 848..1040 CDD:214485 64/218 (29%)
Guanylate_cyc 875..1062 CDD:278633 65/213 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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