DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	359	Identity:	98/359 - (27%)
Similarity:	156/359 - (43%)	Gaps:	78/359 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 DLYAL-----EDDFEHQP----IISTRYAASGLL-----------LVAALALSTLARHMDHEDRV 843
            ::|.|     |:|.|.:|    |.:|.....||.           |:..|.|  .:|:::|
Human   719 EVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQL--YSRNLEH---- 777

  Fly   844 IFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMP 908
                  .|.|:.:.....|.|.:.|.:.:||..|    :|:.|.. ..:..:.|.||.:.|:.:.
Human   778 ------LVEERTQLYKAERDRADRLNFMLLPRLV----VKSLKEK-GFVEPELYEEVTIYFSDIV 831

  Fly   909 NFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRN 973
            .|:......|    .:|.:..||::...||.:::   ..|:.|::|||..||.|||:..:...|
Human   832 GFTTICKYST----PMEVVDMLNDIYKSFDHIVD---HHDVYKVETIGDAYMVASGLPKRNGNR- 888

  Fly   974 DAPITERWSHLAILVEFALELKHALQSINEQSFNHFV-----LKMGINHGPITAGVIGARKPHYD 1033
                     |...:.:.|||:   |..:......|..     :::|::.||..|||:|.:.|.|.
Human   889 ---------HAIDIAKMALEI---LSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYC 941

  Fly  1034 IWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQ--RGLVAVKGKGQLMTFYLQG-KSQ 1095
            ::|:|||.||||||||....|.|:..|..||:.....||.  ||...:||:|...|::|.| |.|
Human   942 LFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQ 1006

  Fly  1096 SSAEPVASGVVVLNGQDSSAVESTSELEA--SDI 1127
            .           .|......||:...|:|  ||:
Human  1007 K-----------FNLPTPPTVENQQRLQAEFSDM 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		CYCc	860..1071	CDD:214485	62/215 (29%)
		Guanylate_cyc	892..1092	CDD:278633	63/206 (31%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364
		PK_GC-C	480..750	CDD:270946	8/30 (27%)
		Pkinase_Tyr	502..745	CDD:285015	7/25 (28%)
		CYCc	788..979	CDD:214485	62/215 (29%)
		Guanylate_cyc	815..1002	CDD:278633	63/206 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810