DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	243	Identity:	71/243 - (29%)
Similarity:	124/243 - (51%)	Gaps:	39/243 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 AFLEAKKSLEVKMVIEEQSAEQE----------------RLLLSVLPKHVAIKMREDLGSSSSEA 290
            |.::|.|.....|:.|:.|...:                |||.||||..||.::|..
Human   396 ARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHK-------- 452

  Fly   291 FKKIYMSRHENVSILYADIVGFTAISSTYS----AQDLVKMLNELFARFDRLAEKYQQ---LRIK 348
             :.:...|::||:||::.||||.|..|.::    |..:|.:||:|:.|||.|.:..:.   .:::
Human   453 -RPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVE 516

  Fly   349 ILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQ 413
            .:||.|..:||.|:....||....|:.|.|::....||....| |.:.:|||||.|:.|::|||.
Human   517 TVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGES-VQITIGIHTGEVVTGVIGQRM 580

  Fly   414 WQFDVYSKDVELANKMESSGKAGRVHISDKTLAFL------NGEFEVE 455
            .::.::...|.|.::.|::|:.|::::|:.|...|      :.:|.:|
Human   581 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLE 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	16/58 (28%)
		CYCc	256..453	CDD:214485	65/225 (29%)
		Guanylate_cyc	294..476	CDD:278633	55/175 (31%)
		CYCc	860..1071	CDD:214485
		Guanylate_cyc	892..1092	CDD:278633
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	15/52 (29%)
		Guanylate_cyc	455..648	CDD:306677	55/175 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810