DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac3 and Adcy8

DIOPT Version :10

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1255 Identity:404/1255 - (32%)
Similarity:630/1255 - (50%) Gaps:216/1255 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGG-------------------------VVILP 50
            ::.|..::|:...|.....::.|..|.|.|  |||                         .||.|
  Rat    90 SLGSGERAHNTGGTKVFPERSGSGSASGSG--GGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFP 152

  Fly    51 -------QHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTI--------------GIPWDQSAP 94
                   ...|..||..|.:.|||.       :..:.|:..:              ..|.|   |
  Rat   153 TLRNSFKSRDLERLYQRYFLGQRRK-------SEVVMNVLDVLTKLTLLVLHLSLASAPMD---P 207

  Fly    95 TRVINCCMLLAY-----LALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQ 154
            .:.|    ||.:     :.:.||:.:.:.:......::..::..:......|.:.|.:.:.    
  Rat   208 LKGI----LLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLL---- 264

  Fly   155 PSFSPRDLLGWAILLNFLVYVTLPLQLIF-----LGLSIGCITYFICLSLPVGYSHWDSLLSNQL 214
                 .|.:|:.:...|..|..|||.|.:     ||.|:..:|..:.:.....:|      .||:
  Rat   265 -----GDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFS------INQV 318

  Fly   215 AANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKM 279
            .|..||.......|:...::.:..|::||||.::.:|.::.:|.::..||||:|||||:.|.::|
  Rat   319 LAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM 383

  Fly   280 REDLGSSSSE----AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAE 340
            ..|:.:...|    .|.:||:.|:||||||:||:.|||.:|:|.|||:||:|||||||||||||.
  Rat   384 INDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAH 448

  Fly   341 KYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVL 405
            ::..||||||||||||:||.|:.|.|||..||.|||||:|.|::|:.:....||||:|||:|:||
  Rat   449 EHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVL 513

  Fly   406 AGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAG 470
            .|:||.|:|||||:|.||::|||:||.|..||:|||..||..|:|::.||...|::|.|.||...
  Rat   514 CGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHGKERNEFLRKHN 578

  Fly   471 LKTYFITK-----------VVKAFASPCAKKINE----TQA----EIAHPNPNGSTTDIVSDEDD 516
            ::||.|.:           :||...| |:.:.|.    |:.    |:...|..|....:.:    
  Rat   579 IETYLIKQPEESLLSLPEDIVKESVS-CSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAA---- 638

  Fly   517 NDATLDDEELLAQNSVS---NGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNI 578
                      |.:||::   |.....:.|.:..||      ..:|::..:..|.|.:...:....
  Rat   639 ----------LTRNSINLLPNHLAQALHVQSGPEE------INKRIEHTIDLRSGDKLRREHIKP 687

  Fly   579 F-LRFKNPQLEQLYAVYR-EPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPI--A 639
            | |.||:..||..|:..| |.:.|..:.|.:::..|..:.|  :||.|.|..:.|...::.:  :
  Rat   688 FSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQS--LLPSSRLMPMTIQFSILIMLHS 750

  Fly   640 MLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIV 704
            .||:|:.||.:. .||..........|: |::.....|..::.|.|...:....:..|.::    
  Rat   751 ALVLITTAEDYK-CLPLILRKTCCWINE-TYLARNVIIFASILINFLGAVINILWCDFDKS---- 809

  Fly   705 SESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAV 769
                                        :|...:.....||.|:...||.|....|||.::..||
  Rat   810 ----------------------------IPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAV 846

  Fly   770 IAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEH--QPIISTRYAASGLLLVAALALST 832
            ..:|..:.|:.:||.:.|::......|...|:...|:..|  :..:.|:.|:..|:.:..||:..
  Rat   847 FLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFY 911

  Fly   833 LARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSY 897
            ..:.:::..|:.|.|:.:..|:.....|:|:.||.::.|:||.|||.||::. .|.:::||||||
  Rat   912 HGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEK-DRDNEELYSQSY 975

  Fly   898 AEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAA 962
            ..|||:|||:|.|:||||:..:||||:||||.|||:|:|||.||...:||||.|||||||||||.
  Rat   976 DAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAV 1040

  Fly   963 SGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGA 1027
            ||::.::....|     :|.||..|.:|:|.|..::|.||:.|||:|.|::||:||.:.||||||
  Rat  1041 SGLSPEKQQCED-----KWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGA 1100

  Fly  1028 RKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG----KGQLMTF 1088
            :||.|||||.|||:||||:|||.:|.|||.|||..||:..|:.|..||.:.|||    :|::.|:
  Rat  1101 KKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTY 1165

  Fly  1089 YLQGK--------------SQSSAEPVASGVV----------VLNGQDSSAVESTSELEASDIKM 1129
            :|.|:              .|.|...|..|:|          :||...:|.:     :::...:.
  Rat  1166 FLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENSNSGI-----IKSHYNRR 1225

  Fly  1130 PLLKMNGPEQSLEID-QDRS 1148
            .||..:|||...:.: .|:|
  Rat  1226 TLLTPSGPEPGAQAEGTDKS 1245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AcyC 122..455 CDD:441717 142/341 (42%)
Guanylate_cyc 294..476 CDD:425528 109/181 (60%)
Guanylate_cyc 892..1092 CDD:425528 114/203 (56%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179 20/97 (21%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106 3/15 (20%)
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117 5/26 (19%)
AcyC 211..564 CDD:441717 148/371 (40%)
Guanylate_cyc 402..586 CDD:425528 110/183 (60%)
Adcy_cons_dom 614..709 CDD:461877 23/114 (20%)
Guanylate_cyc 970..1169 CDD:425528 114/203 (56%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 49/145 (34%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

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