DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac3 and Adcy8

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:1255 Identity:404/1255 - (32%)
Similarity:630/1255 - (50%) Gaps:216/1255 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGG-------------------------VVILP 50
            ::.|..::|:...|.....::.|..|.|.|  |||                         .||.|
  Rat    90 SLGSGERAHNTGGTKVFPERSGSGSASGSG--GGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFP 152

  Fly    51 -------QHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTI--------------GIPWDQSAP 94
                   ...|..||..|.:.|||.       :..:.|:..:              ..|.|   |
  Rat   153 TLRNSFKSRDLERLYQRYFLGQRRK-------SEVVMNVLDVLTKLTLLVLHLSLASAPMD---P 207

  Fly    95 TRVINCCMLLAY-----LALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQ 154
            .:.|    ||.:     :.:.||:.:.:.:......::..::..:......|.:.|.:.:.    
  Rat   208 LKGI----LLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLL---- 264

  Fly   155 PSFSPRDLLGWAILLNFLVYVTLPLQLIF-----LGLSIGCITYFICLSLPVGYSHWDSLLSNQL 214
                 .|.:|:.:...|..|..|||.|.:     ||.|:..:|..:.:.....:|      .||:
  Rat   265 -----GDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFS------INQV 318

  Fly   215 AANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKM 279
            .|..||.......|:...::.:..|::||||.::.:|.::.:|.::..||||:|||||:.|.::|
  Rat   319 LAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM 383

  Fly   280 REDLGSSSSE----AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAE 340
            ..|:.:...|    .|.:||:.|:||||||:||:.|||.:|:|.|||:||:|||||||||||||.
  Rat   384 INDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAH 448

  Fly   341 KYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVL 405
            ::..||||||||||||:||.|:.|.|||..||.|||||:|.|::|:.:....||||:|||:|:||
  Rat   449 EHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVL 513

  Fly   406 AGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAG 470
            .|:||.|:|||||:|.||::|||:||.|..||:|||..||..|:|::.||...|::|.|.||...
  Rat   514 CGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHGKERNEFLRKHN 578

  Fly   471 LKTYFITK-----------VVKAFASPCAKKINE----TQA----EIAHPNPNGSTTDIVSDEDD 516
            ::||.|.:           :||...| |:.:.|.    |:.    |:...|..|....:.:    
  Rat   579 IETYLIKQPEESLLSLPEDIVKESVS-CSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAA---- 638

  Fly   517 NDATLDDEELLAQNSVS---NGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNI 578
                      |.:||::   |.....:.|.:..||      ..:|::..:..|.|.:...:....
  Rat   639 ----------LTRNSINLLPNHLAQALHVQSGPEE------INKRIEHTIDLRSGDKLRREHIKP 687

  Fly   579 F-LRFKNPQLEQLYAVYR-EPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPI--A 639
            | |.||:..||..|:..| |.:.|..:.|.:::..|..:.|  :||.|.|..:.|...::.:  :
  Rat   688 FSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQS--LLPSSRLMPMTIQFSILIMLHS 750

  Fly   640 MLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIV 704
            .||:|:.||.:. .||..........|: |::.....|..::.|.|...:....:..|.::    
  Rat   751 ALVLITTAEDYK-CLPLILRKTCCWINE-TYLARNVIIFASILINFLGAVINILWCDFDKS---- 809

  Fly   705 SESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAV 769
                                        :|...:.....||.|:...||.|....|||.::..||
  Rat   810 ----------------------------IPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAV 846

  Fly   770 IAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEH--QPIISTRYAASGLLLVAALALST 832
            ..:|..:.|:.:||.:.|::......|...|:...|:..|  :..:.|:.|:..|:.:..||:..
  Rat   847 FLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFY 911

  Fly   833 LARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSY 897
            ..:.:::..|:.|.|:.:..|:.....|:|:.||.::.|:||.|||.||::. .|.:::||||||
  Rat   912 HGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEK-DRDNEELYSQSY 975

  Fly   898 AEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAA 962
            ..|||:|||:|.|:||||:..:||||:||||.|||:|:|||.||...:||||.|||||||||||.
  Rat   976 DAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAV 1040

  Fly   963 SGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGA 1027
            ||::.::....|     :|.||..|.:|:|.|..::|.||:.|||:|.|::||:||.:.||||||
  Rat  1041 SGLSPEKQQCED-----KWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGA 1100

  Fly  1028 RKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG----KGQLMTF 1088
            :||.|||||.|||:||||:|||.:|.|||.|||..||:..|:.|..||.:.|||    :|::.|:
  Rat  1101 KKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTY 1165

  Fly  1089 YLQGK--------------SQSSAEPVASGVV----------VLNGQDSSAVESTSELEASDIKM 1129
            :|.|:              .|.|...|..|:|          :||...:|.:     :::...:.
  Rat  1166 FLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENSNSGI-----IKSHYNRR 1225

  Fly  1130 PLLKMNGPEQSLEID-QDRS 1148
            .||..:|||...:.: .|:|
  Rat  1226 TLLTPSGPEPGAQAEGTDKS 1245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 40/162 (25%)
CYCc 256..453 CDD:214485 115/200 (58%)
Guanylate_cyc 294..476 CDD:278633 109/181 (60%)
CYCc 860..1071 CDD:214485 118/210 (56%)
Guanylate_cyc 892..1092 CDD:278633 114/203 (56%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179 20/97 (21%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106 3/15 (20%)
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117 5/26 (19%)
AC_N <158..397 CDD:292831 57/267 (21%)
CYCc 363..561 CDD:214485 114/197 (58%)
Guanylate_cyc 402..586 CDD:278633 110/183 (60%)
DUF1053 614..708 CDD:283888 22/113 (19%)
CYCc 941..1145 CDD:214485 117/209 (56%)
Guanylate_cyc 970..1169 CDD:278633 114/203 (56%)
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248 49/145 (34%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

Return to query results.
Submit another query.