Protein Alignment Ac3 and Adcy6

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1143
• Identity: 376/1143 - (32%)
• Similarity: 571/1143 - (49%)
• Gaps: 210/1143 - (18%)

  Fly    54 LNELYHNYSIKQRRSGLKWFVFAAALFNIWTI--------GIPWDQSAPTRVINCCMLLAYLALT 110
            |..||..|..:..:|.|.  :..|.|..:..:        .:|  |.|...::.|..:|..:.:.
  Rat   148 LERLYQRYFFQMNQSSLT--LLMAVLVLLMAVLLTFHAAPALP--QPAYVALLTCASVLFVVLMV 208

  Fly   111 ALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLN----- 170
            .......|.|                 ::|::|.:...:...:|        :|.|:..|
  Rat   209 VCNRHSFRQD-----------------SMWVVSYVVLGILAAVQ--------VGGALAANPRSPS 248

  Fly   171 -------FLVYVT---LPLQL---IFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIA 222
                   |.||:|   ||:::   :..||.:..:...:...|..|    |..|..||.||.||..
  Rat   249 AGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWHLNNG----DPFLWKQLGANVVLFL 309

  Fly   223 TAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSS 287
            ....||:..::..|..|::||.|.:..::.::.::.::.:||||||||||:|||::|:||:.:..
  Rat   310 CTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKK 374

  Fly   288 SE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILG 351
            .: .|.|||:.:|:|||||:|||.|||:::|..:||:||..|||||||||:||.:...|||||||
  Rat   375 EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 439

  Fly   352 DCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQF 416
            |||||:||.|:.|.|||..||.||:.|::||..|::.....|:||||||:|.|..|:||.|:|||
  Rat   440 DCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQF 504

  Fly   417 DVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI----- 476
            ||:|.||.|||.||:.|:|||:||:..||.:|||::|||...|.:|...|:...::|:.|
  Rat   505 DVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLILGASQ 569

  Fly   477 -----------------------------------TKVVKAFASPCAKKINETQAEIAHPNPNGS 506
                                               ||..|||..   ..|:::..|      |..
  Rat   570 KRKEEKAMLVKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQ---MGIDDSSKE------NRG 625

  Fly   507 TTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHEN 571
            ..|.::.||:.|..|                 |.|:.|...:|::.::.::.|
  Rat   626 AQDALNPEDEVDEFL-----------------GRAIDARSIDQLRKDHVRRFL------------ 661

  Fly   572 LTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLV 636
                    |.|:...||:.|:...:|.....:..||||.|......:||.|.|.| .:.|.|.:.
  Rat   662 --------LTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQFLVFPHSAL-ILGIYAGIF 717

  Fly   637 PIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTE 701
            .:.::.|:..|....|   .||.:..:|.:. :.||   :.:.:..:|..:|  :..|::.:...
  Rat   718 LLLLVTVLICAVCSCG---SFFPNALQRLSR-SIVR---SRVHSTAVGVFSV--LLVFISAIANM 773

  Fly   702 HIVSESEFNVTASLESDINLVVEGMVTAEHL--------LPASFVEQMRDAVPTERVLYPSYLSN 758
            ...|.:.....|:  ..:||.... |||.||        |.|...|   ...||  ..:|.|...
  Rat   774 FTCSHTPLRTCAA--RMLNLTPSD-VTACHLRQLNYSLGLEAPLCE---GTAPT--CSFPEYFVG 830

  Fly   759 FGVLILIAIAVIAQLTHLTKI----------LLLLSIAALHCYF-NIFIMQDLYALE------DD 806
            ..:|.|:|.:|...::.:.|:          ||||.:......| |..::..::.|.      |.
  Rat   831 SVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLASSNETFDG 895

  Fly   807 FEHQPI--ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALV 869
            .:...:  ::.:|....:|||.||||...|:.::...|:.|.||.:...:||...:::..|..|:
  Rat   896 LDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 960

  Fly   870 YNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVI 934
            :|:||..||.||:...:| :|:||.||...|.|:|||:.|||:||.|...||:|:||||.|||:|
  Rat   961 HNILPKDVAAHFLARERR-NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEII 1024

  Fly   935 SDFDALLELPQFQDIIKIKTIGSTYMAASGIN------VQRTVRNDAPITERWSHLAILVEFALE 993
            :|||.::...:|:.:.||||||||||||||:|      |.|            ||:..|.::|:.
  Rat  1025 ADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR------------SHITALADYAMR 1077

  Fly   994 LKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTE 1058
            |...::.|||.|||:|.:|:|:|.||:.|||||||||.||||||||||:|||:|||....||||.
  Rat  1078 LMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTT 1142

  Fly  1059 ETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQS 1096
            :...:|...||....||:|.|||||::.|::|.|...|
  Rat  1143 DLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	144/351 (41%)
		Guanylate_cyc	294..476	CDD:425528	101/181 (56%)
		Guanylate_cyc	892..1092	CDD:425528	106/205 (52%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:318454	62/264 (23%)
		Guanylate_cyc	382..566	CDD:425528	102/183 (56%)
		Adcy_cons_dom	594..681	CDD:461877	24/132 (18%)
		Guanylate_cyc	982..1176	CDD:425528	106/205 (52%)