DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Npr1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1250	Identity:	258/1250 - (20%)
Similarity:	435/1250 - (34%)	Gaps:	474/1250 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 GRRSDKPALRRFHQILLIIVPRALWLLSILH---FTVYVIL------------------------ 153
            |.|..:|.||    .||::.|  |.||...|   .||.|:|
  Rat     3 GSRRVRPRLR----ALLLLPP--LLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALAR 61

  Fly   154 ---QPSFSPRDLLGWAILLNF----------------LVYVTLPLQ---LIFLGLSIGCITYFIC 196
               :|...|    ||.:.:..                |..|.|..:   .:|||  .||    :.
  Rat    62 VKARPDLLP----GWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLG--PGC----VY 116

  Fly   197 LSLPVG--YSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQ 259
            .:.|||  .:||...|         |.|.|..:|                     :.||
  Rat   117 SAAPVGRFTAHWRVPL---------LTAGAPALG---------------------IGVK------ 145

  Fly   260 SAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILYADIVG-----FTAISSTY 319
              ::..|.....|.||      .||...:...:::.. .|:.: :||||.:|     |..:...|
  Rat   146 --DEYALTTRTGPSHV------KLGDFVTALHRRLGW-EHQAL-VLYADRLGDDRPCFFIVEGLY 200

  Fly   320 SAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKY 384
            .                |:.|     |:.|..:....:.|.||..|              |.::.
  Rat   201 M----------------RVRE-----RLNITVNHQEFVEGDPDHYP--------------KLLRA 230

  Fly   385 VQQK------ANSPVDMRVGIHTGAVLAGILGQRQ--WQFDVYSKDVELANKMESSGKAGRVHIS 441
            |::|      .:||...| .:...|:.||:.|:..  :..||:.:.::.|..:          :.
  Rat   231 VRRKGRVIYICSSPDAFR-NLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGL----------VP 284

  Fly   442 DKTLAFLNGEFEVEAAFGEKR--EELLRIAGLKTY----------FITKVVKAFASPCAKKINET 494
            .|..         |...|:.|  .:..:.|.:.||          |: |.:|..|.   ||.|.|
  Rat   285 QKPW---------ERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFL-KQLKLLAD---KKFNFT 336

  Fly   495 QAEIAHPNPNGSTTDIVSDEDDN--DATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQ 557
                            |.|...|  .|:..|..||...:|:.....|..||..       ||..|
  Rat   337 ----------------VEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDG-------ENITQ 378

  Fly   558 RLKDE---------LVTRDGHENLTKDTNIFLRFKNPQL-------------EQLYAV------- 593
            |:.:.         .:.|:|    .:||:..|...:|:.             ::|.||
  Rat   379 RMWNRSFQGVTGYLKIDRNG----DRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYW 439

  Fly   594 ---YREP------------------YSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLV- 636
               |..|                  :|:|.:||  ||..:. |.|:|::.......:.:...||
  Rat   440 PLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLA--LVGSLS-LISFLIVSFFIYRKMQLEKELVS 501

  Fly   637 -----------PIAM----------LVVISLAESFSGMLP-----KFFVDVSKRFNDITFVRELA 675
                       |.::          |.:.....::..:|.     :.|...:....::..|:.:.
  Rat   502 ELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN 566

  Fly   676 AIIIALTIGFSNVIDMFFFVTFVRTEHI---------------------------VSESEFNVTA 713
            ...|.||   ..|:.....:..|:.||:                           :.|:| ::|.
  Rat   567 RKRIELT---RKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENE-SITL 627

  Fly   714 ------SLESDI---------------------NLVVEGMVTAE-----------------HLLP 734
                  ||.:||                     |.||:|....:                 |.|.
  Rat   628 DWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLF 692

  Fly   735 ASFV----EQMRDAVPTERVLYPSYLSNFGVLIL-IAI---------------AVIAQLT----- 774
            |..:    |.:|.|.|..|......:.:||:::. ||:               .:|.::|
  Rat   693 AKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQP 757

  Fly   775 ----------HLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYA--------ASG 821
                      ||.::..|              ||..:| ||..|..|....|.|        :|.
  Rat   758 PFRPSMDLQSHLEELGQL--------------MQRCWA-EDPQERPPFQQIRLALRKFNKENSSN 807

  Fly   822 LLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTK 886
            :|   ...||.:.::.::.:.:       |.|:.:...:.:::.|||:|.:||..|||...:.
  Rat   808 IL---DNLLSRMEQYANNLEEL-------VEERTQAYLEEKRKAEALLYQILPHSVAEQLKRG-- 860

  Fly   887 RSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIK 951
               :.:.::::..|.:.|:.:..|:...:|.|    .::.:..||::.:.|||:::  .| |:.|
  Rat   861 ---ETVQAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVID--NF-DVYK 915

  Fly   952 IKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQS--INEQSFNHFVLKMG 1014
            ::|||..||..||:          |:.....|...:...||.|..|::|  |..:......|::|
  Rat   916 VETIGDAYMVVSGL----------PVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIG 970

  Fly  1015 INHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLF-GYTFLQRGLVA 1078
            |:.||:.|||:|.:.|.|.::|:|||.||||||.|:|..|.::.||..:|..| |:....||.|.
  Rat   971 IHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVE 1035

  Fly  1079 VKGKGQLMTFYLQGK 1093
            :||||::.|::|.|:
  Rat  1036 MKGKGKVRTYWLLGE 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	40/208 (19%)
		CYCc	256..453	CDD:214485	36/209 (17%)
		Guanylate_cyc	294..476	CDD:278633	36/206 (17%)
		CYCc	860..1071	CDD:214485	66/213 (31%)
		Guanylate_cyc	892..1092	CDD:278633	66/202 (33%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	102/548 (19%)
		ANF_receptor	50..410	CDD:279440	94/501 (19%)
		PK_GC-A_B	530..803	CDD:270944	47/291 (16%)
		TyrKc	543..797	CDD:197581	45/272 (17%)
		HNOBA	<812..857	CDD:285003	13/51 (25%)
		CYCc	836..1025	CDD:214485	65/210 (31%)
		Guanylate_cyc	863..1049	CDD:278633	66/202 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810