DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1231	Identity:	264/1231 - (21%)
Similarity:	425/1231 - (34%)	Gaps:	391/1231 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 HVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTIG---IPWDQSAPTRVINCCMLLAYLALTALL 113
            |....:.|.:|:::..:||:   .|....|...:|   :.|:.:......|     |..:|.|.:
  Rat    54 HAPWNISHPFSVQRLGAGLQ---IAVDKLNSEPVGPGNLSWEFTYTNATCN-----AKESLAAFI 110

  Fly   114 HIGRRSDKPALRRFHQILLI--IVPRALWLLSIL--------------------HF--TVYVILQ 154
                    ..::|.|..:||  ..|.|..::.:|                    ||  ...|.|.
  Rat   111 --------DQVQREHISVLIGPACPEAAEVIGLLASEWDIPLFDFVGQMTALEDHFWCDTCVTLV 167

  Fly   155 PSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQL--AAN 217
            |   |:..:| .:|...|.|:......:|.|.|.|              |.|..:  |:|  |..
  Rat   168 P---PKQEIG-TVLRESLQYLGWEYIGVFGGSSAG--------------SSWGEV--NELWKAVE 212

  Fly   218 AVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMRED 282
            ..|.....:...:.|..|.:...:..|.:..|: .:::|...|:|.        .||: ::..||
  Rat   213 DELQLHFTITARVRYSSGHSDLLQEGLRSMSSV-ARVIILICSSED--------AKHI-LQAAED 267

  Fly   283 LGSSSSE------------------------AFKKIYMSRHENVSILYADIVGFTAISSTY--SA 321
            ||.:|.|                        .|.|:|    |:|         |....|||  ||
  Rat   268 LGLNSREFVFLLLQQLEDSFWKEVLAEDKVTRFPKVY----ESV---------FLIAPSTYGGSA 319

  Fly   322 QDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQ 386
            .|           .|...:.||:||......   .||......|..|.|  |..|.:.  .:.|:
  Rat   320 GD-----------DDFRKQVYQRLRRPPFQS---SISSEDQVSPYSAYL--HDALLLY--AQTVE 366

  Fly   387 QKANSPVDMRVGIH---------------TGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAG 436
            :...:..|.|.|..               ||.||....|:|...:.||:        ::.||...
  Rat   367 EMMKAEKDFRDGRQLISTLRADQVTLQGITGPVLLDAQGKRHMDYSVYA--------LQKSGNGS 423

  Fly   437 RVHISDKTLAFL------------------------NGEFEVEAAFGEKREELLRI-----AGLK 472
            |.      |.||                        :.|::.:..|   .|:|.|.     ||:
  Rat   424 RF------LPFLHYDSFQKVIRPWRDDLNASGPHGSHPEYKPDCGF---HEDLCRTKPPTGAGM- 478

  Fly   473 TYFITKVVK-----AFASPCA----------KKINETQAEIAHPN-------------------- 502
            |..:|.|:.     ..||..|          .|:..      ||.
  Rat   479 TASVTAVIPTVTLLVVASAAAITGLMLWRLRGKVQN------HPGDTWWQIHYDSITLLPQHKPS 537

  Fly   503 -----------PNGSTTDIVSDEDDNDATLDDEELL-AQNSVSNGHQIGIAVTADEEEQVKLENF 555
                       .|.||..|.:|......|..||||. |...:..|:.:.:....:|.|
  Rat   538 HRGTPMSRCNVSNASTVKISADCGSFAKTHQDEELFYAPVGLYQGNHVALCYIGEEAE------- 595

  Fly   556 KQRLKDELVTRD-------GHENL-------TKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAA 606
             .|:|...|.|:       .|||:       |:..||.:..:..:...|..|.|.....:..:..
  Rat   596 -ARIKKPTVLREVWLMCELKHENIVPFFGVCTEPPNICIVTQCCKKGSLKDVLRNSDHEMDWIFK 659

  Fly   607 LLVQCIDVLYSYLVLPRSTLHFINIAAP---LVPIAM---LVVISLAESFSGMLPKFF----VDV 661
            |.. ..|::...|.|..|.|.......|   ||...|   |....|.|...|...:.:    .|.
  Rat   660 LSF-VYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEFKHGSTCRIYNQEATDH 723

  Fly   662 SKRF---NDITFVRELAAIIIALTIGFSNVI--DMFFFVTFVRTEHIVSESEFNVTASLESDINL 721
            |:.:   .::..:|||.         :|...  |::.|...:|  .::.:........||:
  Rat   724 SELYWTAPELLRLRELP---------WSGTPQGDVYSFAILLR--DLIHQQAHGPFEDLEA---- 773

  Fly   722 VVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIA 786
                  ..|.::  |.::..|..||    |.||.|.:.|...::|:                 :.
  Rat   774 ------APEEII--SCIKDSRAPVP----LRPSLLEDKGDERIVAL-----------------VR 809

  Fly   787 ALHCYFNIFIMQDLYALEDDFEHQP----IISTRYAAS--GLLLVAALALSTLARHMDHEDRVIF 845
            |  |:            .:..|.:|    |..|...||  |.:.:....:..|..:..|.:.|:.
  Rat   810 A--CW------------AESPEQRPAFPSIKKTLREASPRGRVSILDSMMGKLEMYASHLEEVVE 860

  Fly   846 KWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFM--KNTKRSHDDLYSQSYAEVGVLFASMP 908
            :...::..:|       ::.|.|:..:||..|.|..:  |:.:..|       :..|.:.|:.:.
  Rat   861 ERTCQLVAEK-------RKVEKLLSTMLPSFVGEQLIAGKSVEPEH-------FESVTIFFSDIV 911

  Fly   909 NFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRN 973
            .|:...|    .:..|:.::.||::.|.||..:   |..|:.|::|||..||.|||:    .:||
  Rat   912 GFTKLCS----LSSPLQVVKLLNDLYSLFDHTI---QTHDVYKVETIGDAYMVASGL----PIRN 965

  Fly   974 DAPITERWSHLAILVEFALELKHALQSINEQSFNH-----FVLKMGINHGPITAGVIGARKPHYD 1033
            .|...:         |.|....|.|.........|     ..|::|::.||:.|||:|...|.|.
  Rat   966 GAQHAD---------EIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYC 1021

  Fly  1034 IWGNTVNVASRMESTGKAGAIQVTEETCNILRLF-GYTFLQRGLVAVKGKGQLMTFYLQGK 1093
            ::|:|||:||||||:.....|.|::.|...|.:. ||...:||.::|||||:..||:|.||
  Rat  1022 LFGDTVNMASRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWLTGK 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	38/183 (21%)
		CYCc	256..453	CDD:214485	54/261 (21%)
		Guanylate_cyc	294..476	CDD:278633	48/227 (21%)
		CYCc	860..1071	CDD:214485	63/218 (29%)
		Guanylate_cyc	892..1092	CDD:278633	65/205 (32%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	97/475 (20%)
		ANF_receptor	66..417	CDD:279440	88/435 (20%)
		PK_GC	558..832	CDD:270894	65/340 (19%)
		CYCc	868..1058	CDD:214485	62/223 (28%)
		Guanylate_cyc	895..1081	CDD:278633	66/212 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810