DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	1211	Identity:	225/1211 - (18%)
Similarity:	400/1211 - (33%)	Gaps:	435/1211 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 PLQLIFLGLS------------------IGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATA 224
            |||:::..||                  :.|:..|.. ..|....|.|.:|
Mouse   135 PLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYG-EKPCQMDHLDRIL-------------- 184

  Fly   225 ALIGLLYYFMGEAK----QKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLP----KHVAIKMRE 281
             |.|:.....|:.:    .:|..:.....|.|..|.:.|:.:     :.:||    |...:|.|:
Mouse   185 -LSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGK-----MHILPLVGGKIEEVKRRQ 243

  Fly   282 -DLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQL 345
             .|..||:.|..:.|   |          |.|..::.              :.|:.|.|.|....
Mouse   244 HSLAFSSAGAQAQTY---H----------VSFETLAE--------------YQRWQRQASKVVSQ 281

  Fly   346 RIKILG-DCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVG----IHTGAVL 405
            |:..:. .||     :.:|.|:|        |...:.|.|:..:.|.....|.|    :|..:.|
Mouse   282 RMSTVDLSCY-----SLEEVPEH--------LFYSQDITYLNLRHNFMQLERPGGLDTLHKFSQL 333

  Fly   406 AGI------LGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREE 464
            .|:      ||    .|.|...::....::..|               .||..::.:..|
Mouse   334 KGLNLSHNKLG----LFPVLLCEISTLTELSLS---------------CNGFHDLPSQIG----- 374

  Fly   465 LLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVS-----------DEDDND 518
              ::..|:|..:                :.....|.|:..|:...:.|           .|....
Mouse   375 --KLLNLQTLSL----------------DGNGLTALPDELGNLRQLTSLGISFNDFRHIPEVLEK 421

  Fly   519 ATLDDEELLAQN--SVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTR--DGHENLT----KD 575
            .|:.|:..:|.|  .|.|   :| |:|  ...|||..:.:......::|.  :|::::|    :|
Mouse   422 LTMLDKVAMAGNRLEVLN---LG-ALT--RMSQVKHVDLRMNHLKTVITENMEGNKHITHMDLRD 480

  Fly   576 TNIF------------LRFKNPQLEQL----YAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRS 624
            ..:.            |..:..||.:|    ::: |..|:|...|.|:.|..:..|.:.|.|.::
Mouse   481 NQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSL-RTLYASWNRLTAVNVYPVPSLLTSLELSQN 544

  Fly   625 -------------TLHFINIAAPL---VPIAMLVVISLAESFSG-----MLPKFFVDVSKRFNDI 668
                         .|..::|:..|   ||:.:|..:||.:...|     :||.....:.....||
Mouse   545 LLECVPDWACEAKKLEILDISHNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDI 609

  Fly   669 TFVRELAAIIIALTIGFSNVIDMFFFVTFVRT-EHIVS----ESEFNVTASLESDINLVVEG--- 725
            .. ..|:.:...|   ||..:::.:......: |.:.|    |...:|...|....||:.:.
Mouse   610 QH-NTLSRLPDTL---FSKALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIP 670

  Fly   726 -MVTAEHL------------LPAS---FVEQMRD---------AVPT---------ERVLYPSYL 756
             :|...||            .|||   .:||:.:         |:||         ..|.:.:.:
Mouse   671 VLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLTAIPTTIANCKRLHTLVAHANNI 735

  Fly   757 SNFGVLILIAIAVIAQLT--HLTKILLLLSIAALHCYFNIFIMQDL-------YALE----DDFE 808
            |.|..::.:.......|:  .||:||:..::.|        .:|||       ..||    |.|.
Mouse   736 SIFPEILQLPQIQFVDLSCNDLTEILIPEALPA--------TLQDLDLTGNTNLVLEHKTLDMFS 792

  Fly   809 H--------QPI------ISTRYAASGLLLVAA----LALSTLARHMDHEDRVIFKWKTEVAEQK 855
            |        :|:      :::.:.:.||..:|.    |.:|.||  ||:           .||..
Mouse   793 HITALKIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALA--MDN-----------FAEGV 844

  Fly   856 ETANDM--RQRNEALVYNVLPVHVAEHFMKNTKRSHDD----------------LYSQSYAEVGV 902
            .....|  ..|||.|. .:|...:|:..::..:.|.:|                :..|......:
Mouse   845 GAVYGMFDGDRNEELP-RLLQCTMADVLLEEVQHSTNDTVFMTNTFLVSHRKLGMAGQKLGSSAL 908

  Fly   903 LFASMPNFSDFYS--EETVNNQGLECLRFLNE-----VISDFDALLELPQFQDIIK--------- 951
            |....|:.:|..|  ..||.|.|: |...|..     .:|...:|...|:....:|
Mouse   909 LCYIRPDTADPTSSFSLTVANVGM-CQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITED 972

  Fly   952 ---------IKTIGSTYM----------AASGINVQ---RTVRNDAPITERWSHLAILVEFALEL 994
                     .:.:|.||:          |::.:.:|   ..:.|.|    .|.||:.     ||.
Mouse   973 NKVNGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKA----LWEHLSY-----LEA 1028

  Fly   995 KHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTG---KAGA--- 1053
            .:|::.:.:               |:.|    |:|           :.:..:|.|   ..||
Mouse  1029 VNAVRHVQD---------------PLAA----AKK-----------LCTLAQSYGCQDNVGAMVV 1063

  Fly  1054 -IQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVE 1117
             :.:.||.|        |....||......|...|..|:...:.:....:||:         |.|
Mouse  1064 YLNIGEEGC--------TCEMNGLTLPGPVGFASTAALKDTPKPTTPSSSSGI---------ASE 1111

  Fly  1118 STSELEASDIKMPLLKMNGPEQSLEIDQDRSLRNDSAGQES 1158
            .:||:..|::            |.|:....|..:::.|.|:
Mouse  1112 FSSEMSTSEV------------SSEVGSTASDEHNTVGLEA 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	25/133 (19%)
		CYCc	256..453	CDD:214485	40/212 (19%)
		Guanylate_cyc	294..476	CDD:278633	33/192 (17%)
		CYCc	860..1071	CDD:214485	48/273 (18%)
		Guanylate_cyc	892..1092	CDD:278633	45/244 (18%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	25/140 (18%)
		leucine-rich repeat	285..305	CDD:275380	6/32 (19%)
		leucine-rich repeat	306..332	CDD:275380	6/25 (24%)
		LRR_RI	309..548	CDD:238064	50/287 (17%)
		LRR_8	354..412	CDD:290566	10/95 (11%)
		leucine-rich repeat	356..378	CDD:275380	4/43 (9%)
		leucine-rich repeat	379..401	CDD:275380	5/37 (14%)
		leucine-rich repeat	402..424	CDD:275380	2/21 (10%)
		LRR_8	425..483	CDD:290566	15/63 (24%)
		leucine-rich repeat	425..448	CDD:275380	8/28 (29%)
		LRR_RI	447..714	CDD:238064	52/271 (19%)
		leucine-rich repeat	449..472	CDD:275380	4/22 (18%)
		leucine-rich repeat	474..493	CDD:275380	2/18 (11%)
		leucine-rich repeat	494..513	CDD:275380	4/18 (22%)
		leucine-rich repeat	514..535	CDD:275380	6/21 (29%)
		LRR_8	536..592	CDD:290566	11/55 (20%)
		leucine-rich repeat	536..558	CDD:275380	2/21 (10%)
		leucine-rich repeat	559..581	CDD:275380	6/21 (29%)
		leucine-rich repeat	582..597	CDD:275380	3/14 (21%)
		LRR_8	604..664	CDD:290566	12/63 (19%)
		leucine-rich repeat	604..627	CDD:275380	6/26 (23%)
		leucine-rich repeat	628..653	CDD:275380	3/24 (13%)
		leucine-rich repeat	654..677	CDD:275380	4/22 (18%)
		LRR_8	676..735	CDD:290566	11/58 (19%)
		leucine-rich repeat	678..701	CDD:275380	4/22 (18%)
		leucine-rich repeat	702..724	CDD:275380	3/21 (14%)
		leucine-rich repeat	747..768	CDD:275380	5/20 (25%)
		PP2Cc	816..1065	CDD:238083	56/302 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900