DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	426	Identity:	103/426 - (24%)
Similarity:	177/426 - (41%)	Gaps:	94/426 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 QPSFSPRDLLGWAILLNFLVYVTLP----LQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQL 214
            ||:...|..:.|...|..:|::..|    ||                 .|.....|...:..:..
Mouse   461 QPTLKLRGQMIWMESLKCMVFMCSPKLRSLQ-----------------ELEESKMHLSDIAPHDT 508

  Fly   215 AANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVK----------MVIEEQSAEQERLLLS 269
            ..:.:|:               .:|:.|.:|....||.|          :.||::  :.|.||.:
Mouse   509 TRDLILL---------------NQQRLAEMELSCQLEKKKEELRVLSNHLAIEKK--KTETLLYA 556

  Fly   270 VLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFAR 334
            :||:|||.:::|.         ||:.....|..:||::|:|.||.|.:......:|.|||.::::
Mouse   557 MLPEHVANQLKEG---------KKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSK 612

  Fly   335 FDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSM-VKAIKYVQQKANSPVDMRVG 398
            ||||...:...:::.:||.|..:.|.|.....||....:..|.| :.|.:.:......|:.:|||
Mouse   613 FDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVG 677

  Fly   399 IHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKT-LAFLNGEFEVEAAFGEKR 462
            ||||.||||::|.:..::.::...|..|::|||.|...:||:|... .|..|..||: ...||
Mouse   678 IHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEI-VTRGE-- 739

  Fly   463 EELLRIAG---LKTYFITK-----VVKAFASPCA----KKINETQAEIAHPNPNGSTTDIVSDED 515
               :.:.|   :.|||:.:     .|:....|.|    |:.:..:.::..|..      ::|:.|
Mouse   740 ---IEVKGKGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRA------VLSNMD 795

  Fly   516 DNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVK 551
            .:           |..|.|.....:..||.....||
Mouse   796 HH-----------QQQVYNSDPADVLGTASRTASVK 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	29/144 (20%)
		CYCc	256..453	CDD:214485	63/198 (32%)
		Guanylate_cyc	294..476	CDD:278633	57/186 (31%)
		CYCc	860..1071	CDD:214485
		Guanylate_cyc	892..1092	CDD:278633
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167
		HNOBA	380..566	CDD:400168	28/138 (20%)
		Guanylate_cyc	572..754	CDD:306677	58/187 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810