Protein Alignment Ac3 and Adcy5

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001012783.3
• Gene: Adcy5 / 224129
• MGIID: 99673
• Length: 1262
• Species: Mus musculus
• Alignment Length: 1139
• Identity: 371/1139 - (32%)
• Similarity: 592/1139 - (51%)
• Gaps: 152/1139 - (13%)

  Fly    33 SDVAGGVGITGGGVVI-----------------LPQHVLNELYHNYSIKQRRSGLKWFVFAAALF 80
            |.||.|   :|.|.|:                 .|...|..||..|..:..:|.|.  :..|.|.
Mouse   192 SSVASG---SGTGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLT--MLMAVLV 251

  Fly    81 NIWTIGIPWDQSAPTRVINCCMLLAYLALTA-----LLHIGRRSDKPALRRFHQIL----LIIVP 136
            .:..:.:.:..:.|.      :.:||||:.|     :|.:....::.|..:.|..|    ||.|.
Mouse   252 LVCLVMLAFHAARPP------LQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVV 310

  Fly   137 RALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPV 201
            .|:.::.:|      :.||. |..:.:.|.:...:.:|..||:::....|| |.:...:.|::.:
Mouse   311 LAVQVVGLL------LPQPR-SASEGIWWTVFFIYTIYTLLPVRMRAAVLS-GVLLSALHLAISL 367

  Fly   202 GYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERL 266
            ..:..|..|..||.:|.::.:...::|:..::..|..|::||.|.::.::.::..:.::.:||||
Mouse   368 HTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERL 432

  Fly   267 LLSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNE 330
            ||||||:|||::|:.|:.:...: .|.|||:.:|:|||||:|||.|||:::|..:||:||..|||
Mouse   433 LLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNE 497

  Fly   331 LFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDM 395
            ||||||:||.:...||||||||||||:||.|:.|.|||..||.||:.|::||..|::.....|:|
Mouse   498 LFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNM 562

  Fly   396 RVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGE 460
            |||||:|.|..|:||.|:|||||:|.||.|||.||:.|||||:||:..||.:|||::|||...|.
Mouse   563 RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGG 627

  Fly   461 KREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTT----------------- 508
            .|...|:...::|:.|..        |.:|..|.:|.||..|...:.:
Mouse   628 DRNAYLKEHSIETFLILS--------CTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNH 684

  Fly   509 ---DIVSDEDDNDATLDDEELLAQNSVSNGHQI----GIAVTADEEEQVKLENFKQRLKDELVTR 566
               :.||.|.......|.::..||.|.:...::    |.|:.|...::::.|:.::.|
Mouse   685 LGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFL------- 742

  Fly   567 DGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINI 631
                         |.|:.|.||:.|:...:......:..|.||..........::|.|.......
Mouse   743 -------------LTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFY 794

  Fly   632 AAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRE-----LAAIIIALTIGFSNVIDM 691
            .:..:.:|::|.:|:..:...:.|.....:|::     .||.     |..:.....:..|..::|
Mouse   795 LSCFLLLALVVFVSVIYACVKLFPTPLQTLSRK-----IVRSKKNSTLVGVFTITLVFLSAFVNM 854

  Fly   692 FFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRD-----AVPTERVL 751
            |..            :..|:...|..:.|:.| ..|.|.|::.::|...:.|     ..|.....
Mouse   855 FMC------------NSKNLVGCLAEEHNITV-NQVNACHVMESAFNYSLGDEQGFCGSPQPNCN 906

  Fly   752 YPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYF------NIFIMQDLYALED--DF- 807
            :|.|.:...:|.|:|.:|..|::.:.|::|:|:|..::...      .:|...||....:  ||
Mouse   907 FPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFS 971

  Fly   808 --------EHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQR 864
                    ||...::.:.....::.|..|||...|:.::...|:.|.||.:..|:||...:::..
Mouse   972 NNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAY 1036

  Fly   865 NEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRF 929
            |..|::|:||..||.||:...:| :|:||.||...|.|:|||:.|||:||.|...||:|:||||.
Mouse  1037 NRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL 1100

  Fly   930 LNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERW-SHLAILVEFALE 993
            |||:|:|||.::...:|:.:.||||||||||||||:       ||:...:.. :|:..:.:||::
Mouse  1101 LNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL-------NDSTYDKAGKTHIKAIADFAMK 1158

  Fly   994 LKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTE 1058
            |...::.|||.|||:|.:|:|:|.||:.|||||||||.||||||||||||||:|||....||||.
Mouse  1159 LMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT 1223

  Fly  1059 ETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQG 1092
            :...:|....|....||:|.|||||::||::|.|
Mouse  1224 DMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	143/337 (42%)
		Guanylate_cyc	294..476	CDD:425528	102/181 (56%)
		Guanylate_cyc	892..1092	CDD:425528	105/200 (53%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:318454	68/285 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..194		1/1 (100%)
		Guanylate_cyc	461..623	CDD:425528	97/161 (60%)
		Adcy_cons_dom	669..762	CDD:461877	18/112 (16%)
		Guanylate_cyc	1063..1257	CDD:425528	105/200 (53%)