DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac3 and Adcy5

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_001012783.3 Gene:Adcy5 / 224129 MGIID:99673 Length:1262 Species:Mus musculus


Alignment Length:1139 Identity:371/1139 - (32%)
Similarity:592/1139 - (51%) Gaps:152/1139 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SDVAGGVGITGGGVVI-----------------LPQHVLNELYHNYSIKQRRSGLKWFVFAAALF 80
            |.||.|   :|.|.|:                 .|...|..||..|..:..:|.|.  :..|.|.
Mouse   192 SSVASG---SGTGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLT--MLMAVLV 251

  Fly    81 NIWTIGIPWDQSAPTRVINCCMLLAYLALTA-----LLHIGRRSDKPALRRFHQIL----LIIVP 136
            .:..:.:.:..:.|.      :.:||||:.|     :|.:....::.|..:.|..|    ||.|.
Mouse   252 LVCLVMLAFHAARPP------LQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVV 310

  Fly   137 RALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPV 201
            .|:.::.:|      :.||. |..:.:.|.:...:.:|..||:::....|| |.:...:.|::.:
Mouse   311 LAVQVVGLL------LPQPR-SASEGIWWTVFFIYTIYTLLPVRMRAAVLS-GVLLSALHLAISL 367

  Fly   202 GYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERL 266
            ..:..|..|..||.:|.::.:...::|:..::..|..|::||.|.::.::.::..:.::.:||||
Mouse   368 HTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERL 432

  Fly   267 LLSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNE 330
            ||||||:|||::|:.|:.:...: .|.|||:.:|:|||||:|||.|||:::|..:||:||..|||
Mouse   433 LLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNE 497

  Fly   331 LFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDM 395
            ||||||:||.:...||||||||||||:||.|:.|.|||..||.||:.|::||..|::.....|:|
Mouse   498 LFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNM 562

  Fly   396 RVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGE 460
            |||||:|.|..|:||.|:|||||:|.||.|||.||:.|||||:||:..||.:|||::|||...|.
Mouse   563 RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGG 627

  Fly   461 KREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTT----------------- 508
            .|...|:...::|:.|..        |.:|..|.:|.||..|...:.:                 
Mouse   628 DRNAYLKEHSIETFLILS--------CTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNH 684

  Fly   509 ---DIVSDEDDNDATLDDEELLAQNSVSNGHQI----GIAVTADEEEQVKLENFKQRLKDELVTR 566
               :.||.|.......|.::..||.|.:...::    |.|:.|...::::.|:.::.|       
Mouse   685 LGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFL------- 742

  Fly   567 DGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINI 631
                         |.|:.|.||:.|:...:......:..|.||..........::|.|.......
Mouse   743 -------------LTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFY 794

  Fly   632 AAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRE-----LAAIIIALTIGFSNVIDM 691
            .:..:.:|::|.:|:..:...:.|.....:|::     .||.     |..:.....:..|..::|
Mouse   795 LSCFLLLALVVFVSVIYACVKLFPTPLQTLSRK-----IVRSKKNSTLVGVFTITLVFLSAFVNM 854

  Fly   692 FFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRD-----AVPTERVL 751
            |..            :..|:...|..:.|:.| ..|.|.|::.::|...:.|     ..|.....
Mouse   855 FMC------------NSKNLVGCLAEEHNITV-NQVNACHVMESAFNYSLGDEQGFCGSPQPNCN 906

  Fly   752 YPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYF------NIFIMQDLYALED--DF- 807
            :|.|.:...:|.|:|.:|..|::.:.|::|:|:|..::...      .:|...||....:  || 
Mouse   907 FPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFS 971

  Fly   808 --------EHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQR 864
                    ||...::.:.....::.|..|||...|:.::...|:.|.||.:..|:||...:::..
Mouse   972 NNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAY 1036

  Fly   865 NEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRF 929
            |..|::|:||..||.||:...:| :|:||.||...|.|:|||:.|||:||.|...||:|:||||.
Mouse  1037 NRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL 1100

  Fly   930 LNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERW-SHLAILVEFALE 993
            |||:|:|||.::...:|:.:.||||||||||||||:       ||:...:.. :|:..:.:||::
Mouse  1101 LNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL-------NDSTYDKAGKTHIKAIADFAMK 1158

  Fly   994 LKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTE 1058
            |...::.|||.|||:|.:|:|:|.||:.|||||||||.||||||||||||||:|||....||||.
Mouse  1159 LMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT 1223

  Fly  1059 ETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQG 1092
            :...:|....|....||:|.|||||::||::|.|
Mouse  1224 DMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 44/161 (27%)
CYCc 256..453 CDD:214485 112/197 (57%)
Guanylate_cyc 294..476 CDD:278633 102/181 (56%)
CYCc 860..1071 CDD:214485 105/211 (50%)
Guanylate_cyc 892..1092 CDD:278633 105/200 (53%)
Adcy5NP_001012783.3 AC_N 1..459 CDD:292831 68/285 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..194 1/1 (100%)
CYCc 425..620 CDD:214485 112/194 (58%)
Guanylate_cyc 461..622 CDD:278633 96/160 (60%)
DUF1053 669..761 CDD:283888 18/111 (16%)
CYCc 1037..1238 CDD:214485 105/208 (50%)
Guanylate_cyc 1063..1257 CDD:278633 105/200 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.710

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