Protein Alignment Ac3 and Adcy2

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_705762.2
• Gene: Adcy2 / 210044
• MGIID: 99676
• Length: 1095
• Species: Mus musculus
• Alignment Length: 1201
• Identity: 373/1201 - (31%)
• Similarity: 584/1201 - (48%)
• Gaps: 242/1201 - (20%)

  Fly    23 QTTSRRRQ--NDSDVAGGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTI 85
            |...|||:  .|...|......|||..:  |...:.||.:|....::..|  .||...:
Mouse     3 QEAMRRRRYLRDRAEAAAAAAAGGGEGL--QRSRDWLYESYYCMSQQHPL--IVFLLLI------ 57

  Fly    86 GIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRAL----------- 139
                       |:..|:.|    |.....:|...:.      |...||.||.||
Mouse    58 -----------VMGACLAL----LAVFFALGLEVED------HVAFLITVPTALAIFFAIFILVC 101

  Fly   140 ----------------WLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL--IFLGL 186
                            |:..:....:::....:.|..|.:.:.:.:.|:||..||..:  ..:..
Mouse   102 IESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIAS 166

  Fly   187 SIGCITYFICLSL-----PVGYSH--WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFL 244
            .:...::.|.||:     |....|  |      |:.||.::.....|.|..:..:.|...::.:.
Mouse   167 VLTSSSHTIVLSVYLSATPGAKEHLFW------QILANVIIFICGNLAGAYHKHLMELALQQTYR 225

  Fly   245 EAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL-----GSSSSEA-----FKKIYMSRH 299
            :....::.::.:|.:..:|||||||:||.|:|::|:.::     |..:.:.     |..:|:.||
Mouse   226 DTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRH 290

  Fly   300 ENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDER 364
            .|||||||||||||.::|..|..:||.||||||.:||::|::.:.:|||||||||||:||.|...
Mouse   291 TNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 355

  Fly   365 PDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKM 429
            |:||..||.|||.|.:|||.|:......::||||:|:|.||.|::|.::||:||:|.||.|||.|
Mouse   356 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHM 420

  Fly   430 ESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI------------------ 476
            |:.|..||||||..||..|||.::||...||.|:..|:...:||||:
Mouse   421 EAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRH 485

  Fly   477 -------------TKVVKAFASPCAKKINETQAEIAHPNPNG--STTDIVSDEDDNDATLDDEEL 526
                         |:.::::.:  ||.........:....||  ||||:.
Mouse   486 TLDGAKMRASVRMTRYLESWGA--AKPFAHLHHRDSMTTENGKISTTDVP--------------- 533

  Fly   527 LAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTR-----DG---------HENLTKDTN 577
            :.|::..|             ..::.::.|:|.::||..|     ||         .|::.:
Mouse   534 MGQHNFQN-------------RTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQR--- 582

  Fly   578 IFLRFKNPQLEQLYAVYREPYSSLPLL------AALLVQCIDVLYSYLVLPRSTLHFINIAAPLV 636
            |.|.|.|..:|:.|..     ::||..      |.|:..||.:: ..||||::::...:..|..:
Mouse   583 ISLFFYNKNIEKEYRA-----TALPAFKYYVTCACLIFLCIFIV-QILVLPKTSILGFSFGAAFL 641

  Fly   637 PIAMLVVISLAESFSGMLPKFFVDVSKRFN-DITFVRELAAII-------IALTIGFSNVIDMFF 693
            .:..::.:    .|:|.|    :..||:.: .:.::.:.:.||       |:|||
Mouse   642 SLIFILFV----CFAGQL----LQCSKKASASLLWLLKSSGIIANRPWPRISLTI---------- 688

  Fly   694 FVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVP--------TERV 750
                |.|..|::.:.||:.....|:           |..||.:.......:||        ...:
Mouse   689 ----VTTAIILTMAVFNMFFLSNSE-----------ETTLPTANASNANVSVPDNQTAILHARNL 738

  Fly   751 LYPSYLSNFGVLILIAIAVIAQLTHLTKILLLL------SIAALHCYFNIFIMQDLYALEDDFEH 809
            .:..|.....:|.||:.:|..::.:..|:|:::      :|..||.:.::.   |.|: :..|:.
Mouse   739 FFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNIILLHTHAHVL---DAYS-QVLFQR 799

  Fly   810 QPI---ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYN 871
            ..|   :.|..:.|  |.:..:.|..|.|..::..|:.|.||.:..:::|....|...|..|:.|
Mouse   800 PGIWKDLKTMGSVS--LSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLEN 862

  Fly   872 VLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISD 936
            |||.||||||:..:.: :::||.|||..|.|:|||:|:|.:||:|..||.:||||||.|||:|:|
Mouse   863 VLPAHVAEHFLARSLK-NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIAD 926

  Fly   937 FDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSI 1001
            ||.||..|:|..:.||||||||||||:|::...:..:......::.|:..:||||..|...|.:|
Mouse   927 FDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAI 991

  Fly  1002 NEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRL 1066
            |:.|||.|.|::||||||:.||||||:||.||||||||||||||:|||....|||||||..||:.
Mouse   992 NKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQT 1056

  Fly  1067 FGYTFLQRGLVAVKGKGQLMTFYLQGKSQSS 1097
            .|||...||::.|||||.|.|:::..:...|
Mouse  1057 LGYTCTCRGIINVKGKGDLKTYFVNTEMSRS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	40/198 (20%)
		CYCc	256..453	CDD:214485	105/206 (51%)
		Guanylate_cyc	294..476	CDD:278633	99/181 (55%)
		CYCc	860..1071	CDD:214485	116/210 (55%)
		Guanylate_cyc	892..1092	CDD:278633	113/199 (57%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	51/261 (20%)
		CYCc	240..443	CDD:214485	104/202 (51%)
		Guanylate_cyc	285..469	CDD:278633	100/183 (55%)
		DUF1053	499..603	CDD:283888	26/141 (18%)
		CYCc	852..1060	CDD:214485	115/208 (55%)
		Guanylate_cyc	882..1081	CDD:278633	113/198 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710