Protein Alignment Ac3 and ADCY4

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_640340.2
• Gene: ADCY4 / 196883
• HGNCID: 235
• Length: 1077
• Species: Homo sapiens
• Alignment Length: 1166
• Identity: 388/1166 - (33%)
• Similarity: 584/1166 - (50%)
• Gaps: 222/1166 - (19%)

  Fly    56 ELYHN--YSIKQRRS------GLKWFVFAAALFNIWTIG--IPWDQSAPTRVINCCMLLAYLALT 110
            :|::.  ||:.|:..      |:.....||.|...|..|  :..|.|..|.|:  |.|..:..|
Human    14 DLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVL--CALGGFSLL- 75

  Fly   111 ALLHIGRRSDKPALRRFHQILLIIVPRALW--LLSILH---FTVYVILQPSFSPRDLLGWAILLN 170
                :|..|.:..|:|:.:.|..:|    |  ||::.|   ||..|:     |..|.:.:.:.:.
Human    76 ----LGLASREQRLQRWTRPLSGLV----WVALLALGHAFLFTGGVV-----SAWDQVSYFLFVI 127

  Fly   171 FLVYVTLPLQL---IFLGLSIGCITYFICLSLPVGYSHWDS--LLSNQLAANAVLIATAALIGLL 230
            |..|..|||.:   ...||: ..:::.:.|.|.:| ...||  .|..||||||||.....:.|:.
Human   128 FTAYAMLPLGMRDAAVAGLA-SSLSHLLVLGLYLG-PQPDSRPALLPQLAANAVLFLCGNVAGVY 190

  Fly   231 YYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL--------GS-- 285
            :..:.|...:..|.||..||..:..::.:...||.||||:||.::|.:|:.::        ||
Human   191 HKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRP 255

  Fly   286 SSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKIL 350
            .|:..|..:|:.||:.||:|||||||||.::|..|.::||.||||||.:||::|::::.:|||||
Human   256 ESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKIL 320

  Fly   351 GDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQ 415
            ||||||:||.|...||||:.||.|||.|.:||:.::......::||||:|:|:||.|::|.::||
Human   321 GDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQ 385

  Fly   416 FDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI---- 476
            :||:|.||.|||.||:.|..|||||:..|||.|.|.:.||.|..|.|:..||..|..||.:
Human   386 YDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPR 450

  Fly   477 ----------------------------TKVVKAFASPCAKKINETQAEIAH-PNPNGSTTDIVS 512
                                        |:.::::.:  ||..    |.::| .:|..::|.:
Human   451 AEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGA--AKPF----AHLSHGDSPVSTSTPL-- 507

  Fly   513 DEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFK--QRLKDELVTRDGH-----E 570
                      .|:.||..|.                |..|:..:  :.|.|||.|.|..     |
Human   508 ----------PEKTLASFST----------------QWSLDRSRTPRGLDDELDTGDAKFFQVIE 546

  Fly   571 NL--------TKDTN-IFLRFKNPQLEQLYAV-------YREPYSSLPLLAALLVQCIDVLYSYL 619
            .|        :||.| :.|.|:..::|:.|.:       |.|..:.|..|:..::|       .|
Human   547 QLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQ-------ML 604

  Fly   620 VLPRSTLHFINIAAPLVPIAMLVVISLAESFSGML---PKFFVDVSKRFNDITFVRELAAII--- 678
            |..|.....|..:...:...:::.:..:|.....:   ||.          :.::..|:.::
Human   605 VTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKM----------LHWLPALSGLVATR 659

  Fly   679 --IALTIGFSNVI--------DMFFFVTFVRTEHIVSESEF---NVTASLESDINLVVEGMVTAE 730
              :.:.:|.:.::        .:|||.|       .|:..|   ||::.:.   ||..|
Human   660 PGLRIALGTATILLVFAMAITSLFFFPT-------SSDCPFQAPNVSSMIS---NLSWE------ 708

  Fly   731 HLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIF 795
              ||.|        :|...|.|..:....|.|   :.::...::...|:||||...|..|  ::|
Human   709 --LPGS--------LPLISVPYSMHCCTLGFL---SCSLFLHMSFELKLLLLLLWLAASC--SLF 758

  Fly   796 IMQDLYALE--------DDFEHQPIISTRYAASGLL--LVAALALSTLARHMDHEDRVIFKWKTE 850
            :....:..|        ...:.:|.:.......|.:  .:....|..|||..::..|:.|.||.:
Human   759 LHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKK 823

  Fly   851 VAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYS 915
            :.:::|....|......|:.||||.|||..|:...:| ::|||.|||..|.|||||:|:|.:|||
Human   824 LRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-NEDLYHQSYECVCVLFASVPDFKEFYS 887

  Fly   916 EETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQ--RTVRNDAPIT 978
            |..:|::||||||.|||:|:|||.||..|:|..:.||||||||||||:|:|..  :..:.||
Human   888 ESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDA--- 949

  Fly   979 ER-WSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVA 1042
            || .|||..:||||:.|...|..||:.|||:|.|::|:||||:.||||||:||.|||||||||||
Human   950 ERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVA 1014

  Fly  1043 SRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVAS 1103
            |||||||..|.|||||||...|:..|||...||::.|||||||.|::|......:..|.|:
Human  1015 SRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSAT 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	141/352 (40%)
		Guanylate_cyc	294..476	CDD:425528	96/181 (53%)
		Guanylate_cyc	892..1092	CDD:425528	123/202 (61%)
ADCY4	NP_640340.2	AcyC	68..453	CDD:441717	155/400 (39%)
		Guanylate_cyc	264..418	CDD:425528	84/153 (55%)
		Adcy_cons_dom	479..584	CDD:461877	28/138 (20%)
		Guanylate_cyc	864..1063	CDD:425528	122/201 (61%)