Protein Alignment Ac3 and gcy-34

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_506319.1
• Gene: gcy-34 / 191656
• WormBaseID: WBGene00001554
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 763
• Identity: 153/763 - (20%)
• Similarity: 286/763 - (37%)
• Gaps: 239/763 - (31%)

  Fly   549 QVKLENFKQRLKDELVTRDGHEN-----------------LTKDTNIFLRFKNPQLEQLYAVYRE 596
            |:.:..:.:.:..:::.|.|.||                 |....:|.|:....|:.::|..:..
 Worm    11 QLVIRKYGEDVWLQVLERSGFENGKENIVNHYYSDTDTYVLVDSVSIVLKVTKDQIWEMYGGFLI 75

  Fly   597 PYSSLPLLAALLVQCIDVLYSYLVLPRS-----------TLHFI--------NIAAPLV-----P 637
            .||            :::.:..||...|           :||:.        |:..|..     |
 Worm    76 TYS------------MEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEENP 128

  Fly   638 IAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRT-- 700
            ...|::    ..|:|. |..:..|.      ..|:|:|.::..|.|.         .|...||
 Worm   129 DGTLML----HYFTGR-PGLYHIVK------GVVKEVAKLVFNLDIS---------LVVQGRTQR 173

  Fly   701 -----------EHIV----------SESEFNVTASLES---------DINLVVEGMVTAEHLLPA 735
                       ||::          .:|:.:.|::|.|         |.||.| .:......||.
 Worm   174 SVHMNNGERVEEHVIFLIKNVEEPRRDSDTSTTSALTSVEPDFGEIIDDNLKV-SLQDFSRALPY 237

  Fly   736 SFV-----------EQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALH 789
            .||           :::.:.:|.| :|.|      |..||       ::..:.:..:.|....:.
 Worm   238 HFVLDESCRLVQCGDELYNHIPNE-LLQP------GTPIL-------RIFEINRPQIPLDFENIC 288

  Fly   790 CYFN-IFIM---------------------QDLYALEDDFEHQPI--------------ISTR-- 816
            .:.| :|::                     |::.|:|::.|...:              :||:
 Worm   289 NFINAVFVLQVKTSPLRKKHMNAMTKEEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKH 353

  Fly   817 -------YAAS-GLLLVAALALSTLARHMDHEDRVIFKWK----TEVAEQKETANDM-------- 861
                   |..| ..|:...:.|:.:..|....|.::...:    .||..|.|..|:.
 Worm   354 IIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETMTHEL 418

  Fly   862 ---RQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQG 923
               ||:.::::.::||..:|:..:     |.:.|....| |..|:|..:|.|..........|
 Worm   419 EVERQKTDSILKDMLPRKIAKQLL-----SGEHLEPCEY-EATVMFCDLPAFQQIIPVCQPKN-- 475

  Fly   924 LECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILV 988
              .::.||||....|.::.|   :.:.|::|:..:||..|||....:..     .|...|:|:.:
 Worm   476 --IVKLLNEVFFKLDRIVVL---RGVYKVETVSDSYMTVSGIPDYTSEH-----AENMCHVALGM 530

  Fly   989 EFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGA 1053
            .:  |.:..:..:|:   ..|:|::|::.|.|.|||:|.:.|.|.::|.||.:||:|||.|.||.
 Worm   531 MW--EARSVMDPVNK---TPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGK 590

  Fly  1054 IQVTEETCNILRLFG-YTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVE 1117
            ||.:..|.:.....| :.|..||.:.|||:|.:.|::|....:.|...:......:|   .:::|
 Worm   591 IQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFLMRSLKKSIWEITDHERDVN---VNSIE 652

  Fly  1118 STSELEASDIKMPLLKMNGPEQSLEIDQDRSLRND---SAGQESVAEC 1162
            ...|||                 :.|:..:::::|   .|.|...|.|
 Worm   653 GYEELE-----------------IFIENAQTVKHDGHPKANQNHSATC 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717
		Guanylate_cyc	294..476	CDD:425528
		Guanylate_cyc	892..1092	CDD:425528	61/200 (31%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:462233	30/187 (16%)
		HNOBA	224..441	CDD:462234	38/231 (16%)
		CYCc	421..609	CDD:214485	58/210 (28%)