Protein Alignment Ac3 and gcy-21

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001364740.1
• Gene: gcy-21 / 191651
• WormBaseID: WBGene00001546
• Length: 1163
• Species: Caenorhabditis elegans
• Alignment Length: 1131
• Identity: 227/1131 - (20%)
• Similarity: 406/1131 - (35%)
• Gaps: 361/1131 - (31%)

  Fly   195 IC---LSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKR-----------AF-- 243
            :|   ||...|:.....|:::|         |.:|...:.||:.:.:.|:           ||
 Worm   132 VCEMDLSSVKGFDQTSVLMNSQ---------TNSLAKSVMYFLDKYQWKKVALVSPSTVLTAFAT 187

  Fly   244 ------LEAKKSLEVKMVIE-------------EQSAEQERLLL-------SVLPKHVAIKMRED 282
                  |:|..:.::.::::             ::.||:.|:.:       :.|.::...|:.|.
 Worm   188 RVRSDLLDALTANKIDILVDSRLDPMSDITDKVKEDAEKARIFIICDWSSNANLLRNYLFKLGEM 252

  Fly   283 LGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKM----LNELFARFDRLAEKYQ 343
            ....|.|.|...|:|...|          :..:.::...|.||.:    :|:.....:.|.|.|:
 Worm   253 NKMQSGEYFVLGYISYDTN----------YQWLEASSGDQRLVHLGASDINDYNLTENDLHEVYK 307

  Fly   344 QLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAV---- 404
              .:.||.|      |.|...|:.....:...:.|.|..|......|:.|..::......:
 Worm   308 --NVVILSD------GPPPAEPNSTWEDIKSQVLMKKPAKMCPPYCNTTVSEKITPRWDRIKLLF 364

  Fly   405 -----LAGI------LGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAF 458
                 ||..      :|...:|.|::.:.: ::.|::|        ::..| .|::|...:
 Worm   365 DSIQYLADATNDALNIGANIYQSDIFYEYL-ISRKIDS--------VTGVT-EFIDGYGAI---- 415

  Fly   459 GEKREELLRIAGLKTYFITKVVKAFAS---------PCAKKINETQAEIAH------PNPNGSTT 508
                     :..::.|:      .|:|         |||:.   .|:.:.:      ....|.:.
 Worm   416 ---------VGSIQIYY------HFSSSSHNSYSLFPCARL---AQSSLLNTVWSLTDYSEGLSI 462

  Fly   509 DIVSDEDDNDATL-----------DDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDE 562
            |.|:.....|..:           .:...:...||.....||:|:.|  ....|...:::||...
 Worm   463 DFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAA--AFLYKRYRYERRLHSL 525

  Fly   563 LVTRDGHE-NLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTL 626
            ....|.:: .|.|.||:..:                 .||..:|:        ::..:|....||
 Worm   526 FFMIDRNQIILKKHTNLMSQ-----------------QSLRSMAS--------IHGSVVAASQTL 565

  Fly   627 ---HF----------INI-----------AAPLVPIAMLVVISLAESFSGM-----------LPK 656
               ||          ||.           |.|..||         ..|.|:           :|.
 Worm   566 RDSHFFIEDYNNASSINASSIFNTGSTARAGPFGPI---------PGFGGVTGASEDEKWHQIPD 621

  Fly   657 FFVDV-------SKRF--NDITFVRELAAIIIALTIGF-SNVIDMFFFVTFVRTEHIVSESEFNV 711
            |.|.:       .||.  :|:.|.|.:...|..|.... ||||:  |....|::..:....|...
 Worm   622 FGVGLYEGRTVALKRIYRSDVEFTRSIRLEIAKLQESVNSNVIE--FVGMVVQSPDVFVVYELAQ 684

  Fly   712 TASLESDINLVVEGMVTAEHLLPASFVEQM-RDAVPTERVLYPS--------------------- 754
            ..||:..::       ..:..|...|..|| :|.:.....|:.|
 Worm   685 RGSLKDILD-------NDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMV 742

  Fly   755 YLSNFGVLILIAIAVIAQLTHL---------TKILLLLSIAALHCYFNIFIMQDLYAL------- 803
            .||:||:..|.......|...:         :..||..|.....|...:....|:|:|
 Worm   743 RLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYEL 807

  Fly   804 --------EDDFEHQPIIS--TRYAASGL-------------------LLVAALALSTLARHMDH 839
                    ::..|.:.|:|  .|.|.:|.                   .:|||.....|.|...|
 Worm   808 FGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSLH 872

  Fly   840 E------------------------DRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEH 880
            :                        ::...|.:.::||:.|.....:.::|||:..:||..||:.
 Worm   873 QIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEALLKMMLPEVVADS 937

  Fly   881 FMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQ 945
            ....:..|     ::|:....|.|:..|.|    .|.:..::.::.::|||::.:.||.:::  |
 Worm   938 LKLGSNVS-----AESFENCTVFFSDCPGF----VEMSATSKPIDIVQFLNDLYTVFDRIID--Q 991

  Fly   946 FQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSI------NEQ 1004
            | |:.|::||...||.|||:          |:.....|...:....|.|..|::|.      ||:
 Worm   992 F-DVYKVETIADAYMVASGL----------PVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEK 1045

  Fly  1005 SFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNIL-RLFG 1068
                ..|::|:|.||..|||:|.:.|.|.::|:|||.||||||.|....|..:.....|| :|.|
 Worm  1046 ----VRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGG 1106

  Fly  1069 YTFLQRGLVAVKGKGQLMTFYLQGKS 1094
            |...:||:|.:||||:.||::::|::
 Worm  1107 YEIEERGIVEMKGKGKQMTYFVRGEN 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	55/320 (17%)
		Guanylate_cyc	294..476	CDD:425528	32/200 (16%)
		Guanylate_cyc	892..1092	CDD:425528	67/206 (33%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:471960	55/339 (16%)
		PK_GC	612..881	CDD:270894	51/277 (18%)
		HNOBA	<890..938	CDD:462234	11/47 (23%)
		Guanylate_cyc	944..1130	CDD:425528	68/211 (32%)