Protein Alignment Ac3 and gcy-14

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_506660.2
• Gene: gcy-14 / 191647
• WormBaseID: WBGene00001540
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1129
• Identity: 217/1129 - (19%)
• Similarity: 388/1129 - (34%)
• Gaps: 420/1129 - (37%)

  Fly   300 ENVSILYADIVGF-TAISSTYSAQDLVKMLNELFARFDRLAEKYQ-QLRIKILGDCYYCISGAPD 362
            :..|::.|  ||: |:.::...|:|.:        |.:.|.::|. ...:| ..:|...::|...
 Worm    29 DTASVMRA--VGYRTSAAAVLVARDRI--------RAEHLLDQYDFNFTVK-FDECTEGLAGGKT 82

  Fly   363 -ERPDH-------AVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGI----------- 408
             |..:|       ...|...|:::.....|.    |.|| .:.|:.|.|.:..:
 Worm    83 VELINHDNVDVIIGPTCNRAGIAVASLAAYY----NVPV-FQWGLTTAADIGNVSRYPTTVTLSL 142

  Fly   409 ------LGQRQ----WQFD----VYSKD------VELANKMESSGKAGRVHISDKTLAFL----- 448
                  ||.|:    :::|    :||.|      ..:.:.:|..|    :..||.|||::
 Worm   143 DTHSMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMG----IENSDVTLAYMVQIQT 203

  Fly   449 ---------------NGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEI 498
                           .|.. :.|.|...|       |.|..|:...|.|..|     .:|.....
 Worm   204 VTLDALQKALTEVSKRGRI-IIACFANGR-------GFKKAFVASTVLAGMS-----TDEYMYMF 255

  Fly   499 AHPNPNGSTTDIVS--------DEDDNDAT-LDDEEL---------LAQNSVSNGHQIGIAVTAD 545
            |.|...|...|.::        |.|.|..| |..|::         :..|       :|:..|..
 Worm   256 AEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICDN-------MGLPTTIT 313

  Fly   546 EEEQVKLENFKQRLKDEL-------------------VTRDG-------------HENLTKD--- 575
            .|    ..||..:|...:                   .|..|             :.:||:|
 Worm   314 PE----FANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYAGQLFDAFYAYGVALNRSLTQDPTR 374

  Fly   576 ----------TNIFLRFK------------NPQLEQLYAVYREPYSSLPLLAA-LLVQCIDVLYS 617
                      ::|.:.|:            ..::.|:| ::....|.||.||| |::...:|.|:
 Worm   375 ANLKNGSFVLSDIGMSFQGVGGGTVTLDDTGTRIVQVY-MFALNTSLLPYLAASLVINGSEVEYT 438

  Fly   618 YLVLPRSTLHFIN-IAAPLVPIAMLVVISLAESFSGM-LPKFFVDVSKRFNDITFVRELAAIII- 679
            ......:.|..:. :|.|:.            .|||: .|..||   |.:...|.:   ||:|:
 Worm   439 PFYKSEADLWSVRPLARPIC------------GFSGLECPPDFV---KEYLVYTII---AAVIVV 485

  Fly   680 -ALTIGFSNVI-------------DMFFFVTFVRTEHIVSESEFNVTASLES-------DINLVV 723
             ||..|.:.::             |:.:.|.|:..:.:.|:|:  ..||:.|       ...:.|
 Worm   486 LALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQSKSK--AEASMHSFASGPSTSTKITV 548

  Fly   724 EG----------------MVTAEHLLPASF-------VEQMR----------------------- 742
            |.                :...:|.|...|       ..|||
 Worm   549 ESRSETINFIFYYYQQDILAAMKHDLILQFDAEQKAEFRQMRNFDNDNLNKFIGLCLDGPQLFSL 613

  Fly   743 ----------DAVPTERVLYPSY--------LSNFGVLILIAIAVIAQLTHLTKILLLL------ 783
                      |.:....:...|:        :||  .|:.|..:.:....|||....|:
 Worm   614 WRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISN--GLLFIHNSFLKCHGHLTSRCCLIDDRWQI 676

  Fly   784 -----SIAALHCYFN------------------------------------IFIMQDLYALEDDF 807
                 .:.::..:.|                                    |......:.||:..
 Worm   677 KISGYGLKSVRTFENPKKEDLLWTPPENLRNENEERLPEGDIYSFGIICSEILTRSSAFDLENRK 741

  Fly   808 E-------------HQPIISTRYAASGLLLVAAL----------------ALSTLARH------- 836
            |             |.|:..:......:.:..||                ::..:..|
 Worm   742 EKPDVIIYQVKKGGHNPMRPSLDTGETVEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDG 806

  Fly   837 -----MDHEDRVIFKW----KTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDL 892
                 |||...::..:    :.||:::.:...:.:::::.|:|.:||..||:..     :....:
 Worm   807 RKSNLMDHVFNMLETYASTLEEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKL-----KLGQTV 866

  Fly   893 YSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGS 957
            ..:::.:|.:.|:.:..|:....:.|    .|:.:..||::.:.||.::|.   .|:.|::|||.
 Worm   867 EPETFEQVTIFFSDVVQFTTLAGKCT----PLQVVTLLNDLYTIFDGIIEQ---NDVYKVETIGD 924

  Fly   958 TYMAASGI---NVQRTVRNDAPITERWSHLAIL--VEFALELKHALQSINEQSFNHFVLKMGINH 1017
            .|:..||:   |....:|:.|.::     |..|  :||     ..:|.:..:..|   |::|||.
 Worm   925 GYLCVSGLPHRNGNEHIRHIARMS-----LGFLSSLEF-----FRVQHLPSERIN---LRIGINC 976

  Fly  1018 GPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILR--LFGYTFLQRGLVAVK 1080
            |.:.|||:|...|.|.::|:.||.||||||.||.|.|.||.|...:|.  :.|:....||.|.:|
 Worm   977 GSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIK 1041

  Fly  1081 GKGQLMTFYLQGK----SQSSAEP 1100
            |||.:.|::|.|:    |.|:..|
 Worm  1042 GKGVMETYWLLGEQSRISVSAQAP 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	39/215 (18%)
		Guanylate_cyc	294..476	CDD:425528	44/236 (19%)
		Guanylate_cyc	892..1092	CDD:425528	65/206 (32%)
gcy-14	NP_506660.2	PBP1_NPR_GC-like	21..419	CDD:380575	75/434 (17%)
		Protein Kinases, catalytic domain	535..800	CDD:473864	28/266 (11%)
		HNOBA	<816..860	CDD:462234	8/43 (19%)
		CYCc	839..1031	CDD:214485	62/216 (29%)