Protein Alignment Ac3 and gcy-13

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_506097.3
• Gene: gcy-13 / 191646
• WormBaseID: WBGene00001539
• Length: 1028
• Species: Caenorhabditis elegans
• Alignment Length: 1106
• Identity: 210/1106 - (18%)
• Similarity: 365/1106 - (33%)
• Gaps: 393/1106 - (35%)

  Fly   307 ADIVGF-TAISSTYSAQDLVKM--------LNELFARFDRLAEKYQQLRIKILGDCYYCISGAPD 362
            |..||: |:.|:...|.|.:|.        :|.::...|....|...|..|:|.|........|
 Worm     2 ASSVGWQTSASAIEIAMDRIKSEHLIDNIGINFIYVFDDCNEAKAAGLSSKLLMDANVSAIVGP- 65

  Fly   363 ERPDHAVLCVHMGLSMVKAIKYVQQKANSPV----------------------DMRVGIHTGAVL 405
                   .|...||::|....|.    |:||                      .:.|.....|.:
 Worm    66 -------TCNAAGLAVVNLAGYY----NTPVLTWGLTISSSFIDTSKYPTTVTIVPVAKSIAAAI 119

  Fly   406 AGILGQRQWQFDVY-----------SKDVE-LANKMESSGKAGRVHISDKTLAFLNGEFEVEAAF 458
            ..::.|.:|...||           ..|:| :.:....:..:..:.|.|::...|..:.
 Worm   120 HEVMIQFEWTEFVYVFVEDEKCGYFRDDLEQITSDSNYTSLSRTIQIYDQSYTNLVRQL------ 178

  Fly   459 GEKREELLRI-------AG-LKTYFI----------TKVVKAFASPCAKKINETQAEIAHPNPNG 505
             ||.:.:.||       || :|..|:          .:.|..||.|.:....:|          .
 Worm   179 -EKLKTVSRIFTVCLPEAGDIKRRFMLAAYDLDMTTDEYVYLFAGPKSTAYQQT----------S 232

  Fly   506 STTDIVS---DEDDNDATLDDEELLA-------QNSVSNGHQIGIAVTADEEEQVKL-------- 552
            ||.|:|.   |..:|....|:|..||       ..:...|.|.. |...:..|::||
 Worm   233 STGDVVGIWVDWSENPDGRDEEAKLAFMRTMVIVATPVQGEQYA-AFKKEVIERMKLPPYNCVDE 296

  Fly   553 ---------ENFKQRLKDEL----------VTRDGHENLTKDTNIFLRFKNPQLEQLYAV----- 593
                     ..:..:|.|.:          :...|.|.:...:||..|....:.|.:..|
 Worm   297 CKEKEYQEAAEYADQLHDTIYLYALILNKTIEEQGIEQIANGSNIVTRGAGIEFEGMSGVVRMNG 361

  Fly   594 --YREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLV--PIAMLVVISLAESFSGML 654
              ||.|..:|..|.:...|             .|:.:::|.:..|  ..|::....:.::::|.|
 Worm   362 IGYRLPNMNLANLDSNATQ-------------RTVAYMDIDSTSVNWTFAIIDQALIWDAYNGKL 413

  Fly   655 PK---------------FFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIV 704
            |:               |||       |..::..:.|:||.|... :..|..|..:...|.|.:.
 Worm   414 PQTRPECGYSGKSCPVNFFV-------DYLYIVVIVAVIIVLCCA-AAAIAAFLVIKARRDEELR 470

  Fly   705 SESEFNVTASLESDINLVVEGMVTAEH----LLPASFVEQMRDAVPTERVLYPSYLSNFGVLILI 765
            .:.::.|...:   :..:::|...:.|    |...|........:.:..|.:|. ....|..:.:
 Worm   471 LDDQWIVPHGM---LQSIIKGRKESHHSSRSLQSNSTTTTGTTGISSRSVFFPE-TETQGYFVYM 531

  Fly   766 AIAVIAQLTHL---------TKILLLLSIAALHCYFNIFI--------------------MQD-- 799
            ...|:|:...|         :::.:|.||.  |...|.||                    ::|
 Worm   532 NEPVLARKYQLRVPIFKQDRSELRMLRSIE--HDNVNRFIGLSIDGPVYMSFWRYCSRGSIKDVI 594

  Fly   800 -----------LYALEDD-------FEHQPI------------ISTRY----------------- 817
                       :|.|..|       ..|.||            |:.|:
 Worm   595 AKSSINMDGFFIYCLIKDIASGLQYIHHSPIKQHGSLTSECCYINDRWQVKIGSYGLSFMQGVEK 659

  Fly   818 -AASGLLLVA--------------------ALALSTLARH---------MDHEDRVIFK------ 846
             ...|||..|                    ::..|.|..|         .:..|.:||.
 Worm   660 RTEDGLLHTAPEVLREGLTSGTQAGDVYSFSIVCSELVGHSSAWNLENRKEEADEIIFMVKRGGR 724

  Fly   847 -------------------------W--------------------------------------- 847
                                     |
 Worm   725 TPFRPSLDDVDDDINPAMLHLIRDCWDEDPKQRPNIDMVNKLMKNMNSGRSGSANLMDHVFSVLE 789

  Fly   848 ------KTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFAS 906
                  :.||.|:.:...:.:::::.|:|.:||..|||..     :....:..:::..|.:.|:.
 Worm   790 KHASSLEDEVQERMKELVEEKKKSDILLYRMLPQQVAERL-----KLGQSVEPEAFESVTIFFSD 849

  Fly   907 MPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTV 971
            :..|:...::.|    .|:.:..||::.:.|||::|.   .|..|::|||..|:..||:
 Worm   850 VVGFTVLANKST----PLQVVNLLNDLYTTFDAIIEK---NDSYKVETIGDAYLVVSGL------ 901

  Fly   972 RNDAPITERWSHLAILVEFALELKHALQS--INEQSFNHFVLKMGINHGPITAGVIGARKPHYDI 1034
                |......|:|.:...:|||..:||:  |.........:::|::.|...|||:|...|.|.:
 Worm   902 ----PRRNGTEHVANIANMSLELMDSLQAFKIPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCL 962

  Fly  1035 WGNTVNVASRMESTGKAGAIQVTEETCNILRLF--GYTFLQRGLVAVKGKGQLMTFYLQGKSQSS 1097
            :|:|||.||||||.||.|.|.::.:..::|...  .|....||.|.:||||.:.|::|.|..:.|
 Worm   963 FGDTVNTASRMESNGKPGFIHLSSDCYDLLTSLYKEYNTESRGEVIIKGKGVMQTYWLLGMKEES 1027

  Fly  1098 A 1098
            |
 Worm  1028 A 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485	35/188 (19%)
		Guanylate_cyc	294..476	CDD:278633	42/219 (19%)
		CYCc	860..1071	CDD:214485	59/214 (28%)
		Guanylate_cyc	892..1092	CDD:278633	61/203 (30%)
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347	81/436 (19%)
		ANF_receptor	13..368	CDD:279440	70/384 (18%)
		PKc_like	548..770	CDD:304357	27/223 (12%)
		HNOBA	<797..829	CDD:285003	10/31 (32%)
		CYCc	808..1000	CDD:214485	58/213 (27%)
		Guanylate_cyc	835..1022	CDD:278633	61/203 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810