DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and gcy-6

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	682	Identity:	158/682 - (23%)
Similarity:	278/682 - (40%)	Gaps:	160/682 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 EKREELLRIAGLKTYFITK---------VVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDED 515
            |::..|.:|.......:||         .:.:..|..:...:.|.:|:      |.|.:.:..:.
Worm   519 ERQNALWQIPFKSMMTVTKKGKGEHSMRSISSVPSTISSTRSSTLSEV------GETRNYLFFQI 577

  Fly   516 DNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFL 580
            .||..:  |.:.|:..       .|.:..|.:....:.  :.||.|       |.||.|...:.|
Worm   578 QNDVEM--ERVAAKKH-------SIRMVFDNKTCATMR--QMRLID-------HANLNKFIGMSL 624

  Fly   581 RFKNPQLEQLYAVYREPYSSLPLLAALLVQC---IDVLYSYLVLPRSTLHFINIAAPLVPIAMLV 642
                 ...|||:|:|  :.|...||.::.:.   :|..:.|.::.    ..||        .:..
Worm   625 -----DAPQLYSVWR--FCSRGSLADVIRKASMQMDGFFIYSLMK----DIIN--------GLTW 670

  Fly   643 VISLAESFSGMLPKFFVDVSKR--FNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVS 705
            :...:..|.|||      .||.  .||...::               :.|  |.:...||....:
Worm   671 IHESSHEFHGML------TSKNCLLNDRWQLK---------------ITD--FGLRIFRTHDQYN 712

  Fly   706 ESE-----------FNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNF 759
            :|:           .::..|.|.||...  |:::||.:..:|..:........|.::|  .|...
Worm   713 KSDRLWTSPELLRTDDILGSREGDIYSF--GIISAELITRSSVFDLENRKEDAEEIIY--MLKKG 773

  Fly   760 GVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLL 824
            |:.     :....|.|...|  .::.|.||      :::|.:. |...|...|   :..||.|..
Worm   774 GLQ-----SPRPSLEHDESI--EINPALLH------LVRDCWT-ERPSERPDI---KQVASQLRS 821

  Fly   825 VAALALSTLARHMDHEDRVIFKW----KTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNT 885
            :.......|   |||...|:..:    :.||||:.:...:.:::::.|:|.:||..||:. :|..
Worm   822 MNTNRNDNL---MDHVFNVLESYASTLEDEVAERMKELVEEKKKSDVLLYRMLPRQVADK-LKLG 882

  Fly   886 KRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQ--GLECLRFLNEVISDFDALLELPQFQD 948
            :....:.:     ::..||     |||..|..|:..:  .|:.:..||.:.:.||.::|.   .|
Worm   883 QTVEPETF-----DIVTLF-----FSDVVSFTTLAGKCTPLQVVNLLNGLYTIFDGIIEQ---HD 934

  Fly   949 IIKIKTIGSTYMAASGI---NVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNH-- 1008
            :.|::|||..|..|||:   |.....||.|.::         :.|       ::|:.:.|..|
Worm   935 VYKVETIGDGYFVASGVPRRNGNEHTRNIASMS---------INF-------VKSLADFSIPHLP 983

  Fly  1009 ---FVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNIL-RLFGY 1069
               ..:::|.:.|.:.|||:|...|.|.::|:.||.||||||..|.|.|.::||...:| ||.|:
Worm   984 GEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNSKPGQIHLSEEANQMLMRLGGF 1048

  Fly  1070 TFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPV 1101
            |...||.|.:||||.:.|::|....:|:|..:
Worm  1049 TTEPRGEVIIKGKGVMATYWLLKMDESAAPKI 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633	3/15 (20%)
		CYCc	860..1071	CDD:214485	63/221 (29%)
		Guanylate_cyc	892..1092	CDD:278633	66/210 (31%)
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347
		ANF_receptor	57..424	CDD:279440
		PKc_like	585..822	CDD:304357	61/315 (19%)
		HNOBA	<847..879	CDD:285003	10/32 (31%)
		CYCc	858..1048	CDD:214485	62/219 (28%)
		Guanylate_cyc	885..1070	CDD:278633	65/213 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910