Protein Alignment Ac3 and gcy-5

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_496219.1
• Gene: gcy-5 / 191643
• WormBaseID: WBGene00001532
• Length: 1122
• Species: Caenorhabditis elegans
• Alignment Length: 1124
• Identity: 224/1124 - (19%)
• Similarity: 387/1124 - (34%)
• Gaps: 370/1124 - (32%)

  Fly   232 YFM-----GEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAF 291
            |:|     ..|...:|.::..|.:.|.:|:.....:    .|:::             .:.|..:
 Worm    73 YYMEYTECDRASVAKAGMKFMKEMNVDVVVGPSCGD----ALAIM-------------GTLSAIY 120

  Fly   292 KKIYMSRHENVSILYADIVGFTAISSTY-SAQDL---VKMLNELFARFDRLAEKYQQLRIKILGD 352
            ||:.:..........||...|..::|.. :||.|   ...:.|:| :|||:|..|.:      .|
 Worm   121 KKLVLGWGFVSDTQLADTNRFPYVASVQPTAQTLGLATSRILEMF-QFDRVALLYYK------DD 178

  Fly   353 CYYCISGAPD-----ERPD-HAVLCVHMG----------LSMVKAIKYVQQKANSPVDMRVGIHT 401
            ..||.|...|     ..|| :.|..|..|          .|.::|:|           .|..|
 Worm   179 QDYCKSVMDDVEATLSDPDLYPVRIVWKGELQSDNEALTRSTLQAVK-----------SRARI-- 230

  Fly   402 GAVLAGILG--QRQWQFDVYSKD------VELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAF 458
             .:|..|.|  :|.:...:..::      |.:...|.|.|...:..:..||  |.||
 Worm   231 -VLLCAISGPEKRNYLISIAQQNMTTNEYVHILLTMRSIGYGVQTSLGKKT--FANG-------- 284

  Fly   459 GEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDD------- 516
                             :|.:.::|.  .|...|||.|..|....  ...|:.||..|
 Worm   285 -----------------LTPLWESFT--VAPDGNETNARRAAEKM--LVIDVNSDVQDAEFLQYL 328

  Fly   517 ----NDAT------LDDEELLAQNSVSNG----------HQIGIAVTADEEEQVKLENFKQRLKD 561
                .||.      .:..|.:..:|.|.|          :..|:||:........:......|..
 Worm   329 TKNIADAVRNPPMKCNTSECINASSTSMGSYARHLFDVFYLYGMAVSKLNSTDPTVYGNLNLLMP 393

  Fly   562 ELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVL-YSYLVLPRST 625
            ::||  ..:.:|....|..........|||.: .|.|..:.|:..........| ..|....||.
 Worm   394 QMVT--SFDGMTGRVQIGQNLYRVPTYQLYGL-DEKYEQVALVNMTFYNSSSQLSRGYSDEGRSV 455

  Fly   626 LHFINIAAPL-VPIAMLVVISLAESFSG-MLPKFFVDVSKRFNDITFVRELAAI----IIALTIG 684
            .||.:...|| .||.         .||| ..|..|.|   ::..:.||..:..|    |:.:..|
 Worm   456 WHFWDGTRPLDTPIC---------GFSGRYCPVQFWD---QYGVLIFVASIVLIFLICIMLMCFG 508

  Fly   685 FSNVIDMFFFVTFVRTEHIVSESEFNVTA-----------------SLESDINLVV-EGMVTAEH 731
                    |.:...|.|.....||:.:.:                 ||:|..:.:. |..:|.:.
 Worm   509 --------FMIRGRRAEQERLNSEWQIPSIQLIMPQKEKRKPNSRRSLQSGPSTITGESKMTIDG 565

  Fly   732 LLPASFVEQM--RDAVPTE------------------RVLYPSYLSNF-GVLI----LIAI---- 767
            ....::..||  :|.|.|.                  |.|....|:.| |:.|    .:|:
 Worm   566 GFHENYTVQMFEKDLVLTTKHHSMQMNKEEKEKFVKLRKLEHDNLNKFIGLSIDGPQFVAVWKMC 630

  Fly   768 ------AVIAQ-------------LTHLTKILLLLSIAALHCYFNI----FIMQDLYALE-DDF- 807
                  .:||:             :|.:.:.:..|..:.||.:.|:    .::.|.:.:: .||
 Worm   631 SRGSLQDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSFLHLHGNLRSATCLVNDSWQVKLTDFG 695

  Fly   808 ------EHQP-------------------------------------IISTRYA----------- 818
                  ||.|                                     |::.|.|
 Worm   696 LGALLEEHTPSKKRLLWAAPEVLRGSLTIHQMDPSADVYSFAIIASEILTKREAWDISNRKEGAD 760

  Fly   819 --------------ASGLLLVAALA--LSTLARH------------------------------M 837
                          ...|:|.|.::  |:||.:.                              |
 Worm   761 EILYMVKKGGNRTIRPELILDAEVSPRLTTLVKDCWSEQPEDRPKAEQICKLLSEMTPRGNTNLM 825

  Fly   838 DHEDRVIFKW----KTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYA 898
            ||...::.::    :.::.|:.:.....:::.:.|:..:||..|||..     ::...:..:.:.
 Worm   826 DHVFNMLEEYTSTLEVDIEERTKELTLEKKKADILLSRMLPKQVAERL-----KAGQTVEPEGFD 885

  Fly   899 EVGVLFASMPNFSDFYSE----ETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTY 959
            .|.|||:.:..|:...::    :.||        .||::.|:||.::|   ...:.|:::||..|
 Worm   886 TVTVLFSDVVKFTQLAAKCSPFQVVN--------LLNDLYSNFDTIIE---EHGVYKVESIGDGY 939

  Fly   960 MAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSF--NHFVLKMGINHGPITA 1022
            :..||:          |....::|:..:|:.:|:.....:|......  ....|::|||.||..|
 Worm   940 LCVSGL----------PTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGINSGPCVA 994

  Fly  1023 GVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILR---LFGYTFLQRGLVAVKGKGQ 1084
            ||:|...|.|.::|:|||.||||||.||...|.::|...::|.   ...|....||.|.:||||.
 Worm   995 GVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVIIKGKGV 1059

  Fly  1085 LMTFYLQGKSQSSAEPVAS 1103
            :.||::.||:.|..:.:::
 Worm  1060 METFWVLGKTDSDTKSLST 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	8/57 (14%)
		CYCc	256..453	CDD:214485	46/224 (21%)
		Guanylate_cyc	294..476	CDD:278633	42/209 (20%)
		CYCc	860..1071	CDD:214485	58/219 (26%)
		Guanylate_cyc	892..1092	CDD:278633	61/208 (29%)
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347	85/438 (19%)
		ANF_receptor	49..426	CDD:279440	82/424 (19%)
		PK_GC	546..816	CDD:270894	39/269 (14%)
		HNOBA	<830..873	CDD:285003	7/42 (17%)
		CYCc	852..1042	CDD:214485	57/215 (27%)
		Guanylate_cyc	879..1067	CDD:278633	61/208 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810