Protein Alignment Ac3 and gcy-3

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_496037.1
• Gene: gcy-3 / 191641
• WormBaseID: WBGene00001530
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 1126
• Identity: 216/1126 - (19%)
• Similarity: 378/1126 - (33%)
• Gaps: 344/1126 - (30%)

  Fly   237 AKQKRAFLEAKKSLEVKMVIEEQSAEQER-------------------------------LLLSV 270
            |...|..:...|:|||.::|....:|..|                               .|::|
 Worm    89 ASTVRTGINFLKNLEVDVIIGPPCSEAIRTMATLATLYKKPVLGWGFVSQADLSDMTRFPYLITV 153

  Fly   271 LPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILY------------ADIVGFTAISSTYSAQD 323
            ||      ..:.||.::|   |.:.:.:.:.|::||            .|:.......||||.|.
 Worm   154 LP------TSQTLGYAAS---KLLELYKWDKVALLYYKSEVNHCGGVMNDVETTFNDPSTYSIQI 209

  Fly   324 LVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQK 388
            ::|.  |:.|. |.:........:|.........:....|:.|:.:....:||...:.:..:
 Worm   210 VLKA--EIDAS-DNVTTNAVISSVKTRARIILWCAQLGSEKRDYMIKISQLGLDTDEYVHVL--- 268

  Fly   389 ANSPVDMR---VGIHTGAVLAGILGQRQWQFD----VYSKDVELANKMESSGKAGRVHISDKTLA 446
                :.||   .|:.|      .:|:..::..    |:.....:.:.:|:..|.|..::   .:.
 Worm   269 ----ISMRSIGFGVQT------FVGKTTFKLSGLTPVWESFSNVTDGLENVAKRGATNV---LVI 320

  Fly   447 FLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIV 511
            .||.|...:|.....:..:|.:..|                             |..|.||.|.|
 Worm   321 DLNSEVSDKAYLDYMQRNILNVVKL-----------------------------PPLNCSTVDCV 356

  Fly   512 SDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDT 576
            |      :|.......|::.....:..|||:|........:.:...:|..:.||  ....:|...
 Worm   357 S------STATGMGAYARHLFDVVYLYGIALTRVNSTDSAVYDDMSKLIPQFVT--SFNGMTGLV 413

  Fly   577 NIFLRFKNPQLEQLYAVYREPYSSLPLL-----AALLVQCIDVLYSYL----------VLPRST- 625
            .|........|.|||.: .|.|....|:     ....|..|.:.||..          :.|.:|
 Worm   414 AINQNLSRMPLYQLYGL-DEQYEQTSLMNLSFADGTTVATISLAYSNESSAVWHFWGGIRPLATP 477

  Fly   626 -LHFINIAAPL-------------VPIAMLVVISLAESFSGMLPKFFVDVSKRFN---DITFV-- 671
             ..|:..:.||             ..:.::::.:....|..|: |...:...|.|   .|.||
 Worm   478 ICGFLGNSCPLPFWEQYGILIFVGAGVFLIMITTNLICFLFMI-KNRREEQARINSEWQIPFVKL 541

  Fly   672 REL----------------AAII-----------------------IALTIGFS----NVIDMFF 693
            |||                :.|.                       :.||:.|.    |..||..
 Worm   542 RELERKSKGTSKRSLQSAPSTITGESKVSTGSEFCENYEVKMFEKDMVLTMKFQYMNLNKADMDK 606

  Fly   694 FVTFVRTEH---------IVSESEFNVTASLESDINL----------------------VVEGMV 727
            ||...:.:|         .:..|:|.....|.|..:|                      |.|||.
 Worm   607 FVKLRKLDHENLNKFIGLSIDSSQFISVTKLCSRGSLLDILYKGNFSMDFFFMYCIIKDVAEGMS 671

  Fly   728 --------------TAEHLLPAS---------FVEQMRDAVPTERVLY---PSYLSNFGVLILIA 766
                          :|..|:..|         |.:.:.:..||:|.|.   |.        :|..
 Worm   672 YLHKSFLRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEEITPTKRRLLWAAPE--------VLRG 728

  Fly   767 IAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALED----------------DFEHQPIIST 815
            ...::|:.....:.....||:     .|...::.:.|::                .|..:|.|.|
 Worm   729 SLTVSQMDPSADVFSFAIIAS-----EILTRKEAWDLKERKEGYDEIIYRVKKGGSFPIRPDIIT 788

  Fly   816 RYAASGLLLVAA------------------------LALSTLARHMDHEDRVIFKW----KTEVA 852
            ........|:|.                        |...|.:..|||...::.::    :.||.
 Worm   789 DVPDVNPTLIALVKDCWAEAPEDRPTAENICEQLRDLMPKTKSNLMDHVFNMLEEYTSTLEVEVE 853

  Fly   853 EQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEE 917
            |:.:.....:::.:.|:..:||..|||..     ::...:..:.:..|.|.|:.:..|:...|:.
 Worm   854 ERTKELTLEKKKADLLLSRMLPKQVAERL-----KAGQTVEPEGFDSVTVFFSDVVKFTILASKC 913

  Fly   918 TVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWS 982
            |    ..:.:..||::.|:||.::|   ...:.|:::||..|:..||:          |....::
 Worm   914 T----PFQVVNLLNDLYSNFDTIIE---EHGVYKVESIGDGYLCVSGL----------PTRNGFN 961

  Fly   983 HLAILVEFALELKHALQS--INEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRM 1045
            |:..:|:.:|:.....::  |.........|::|:|.||..|||:|...|.|.::|:|||.||||
 Worm   962 HIKQIVDMSLKFMDYCKNFKIPHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRM 1026

  Fly  1046 ESTGKAGAIQVTEETCNILRL---FGYTFLQRGLVAVKGKGQLMTFYLQGK--------SQSSAE 1099
            ||.||...|.:|.:...:|..   ..|....||.|.:||||.:.||::.|:        |..|..
 Worm  1027 ESNGKPSLIHLTSDAHLLLMKHFPHQYETNSRGEVIIKGKGVMETFWVLGRSGDIEPSISNRSTP 1091

  Fly  1100 PVASGVVVLNGQDSSAVESTS 1120
            ||......:...|:....|.|
 Worm  1092 PVTQERFTVRAPDTPEARSVS 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	14/78 (18%)
		CYCc	256..453	CDD:214485	41/246 (17%)
		Guanylate_cyc	294..476	CDD:278633	33/200 (17%)
		CYCc	860..1071	CDD:214485	56/215 (26%)
		Guanylate_cyc	892..1092	CDD:278633	59/204 (29%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347	76/429 (18%)
		ANF_receptor	54..433	CDD:279440	72/409 (18%)
		PKc_like	554..823	CDD:304357	40/281 (14%)
		HNOBA	<839..882	CDD:285003	9/42 (21%)
		CYCc	861..1051	CDD:214485	55/211 (26%)
		Guanylate_cyc	888..1076	CDD:278633	59/204 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810