Protein Alignment Ac3 and acy-2

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_504553.1
• Gene: acy-2 / 191607
• WormBaseID: WBGene00000069
• Length: 1080
• Species: Caenorhabditis elegans
• Alignment Length: 1163
• Identity: 322/1163 - (27%)
• Similarity: 509/1163 - (43%)
• Gaps: 313/1163 - (26%)

  Fly    71 KW--FVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTAL-LHIGRRSDKPALRRFHQILL 132
            ||  |.|.|::|                      .:|||.||.. :.|.:..:...|......|.
 Worm    77 KWSPFCFYASIF----------------------FIAYLILTCFAIRIRQPKEGMGLVLVSLSLC 119

  Fly   133 IIVPRALWLLSIL----------------HFTVYV------ILQPSFSPRD-------LLGWAIL 168
            :::|...|:|.:.                |..:|.      ::|....||.       .:.| |:
 Worm   120 VLLPAFSWILHLPVVIFVSRERIHTNEHDHSALYTSLCIASVIQFFILPRHRRIFFVVAVSW-IV 183

  Fly   169 LNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLL-------SNQLAANAVLIATAAL 226
            .|||:.|.:...    .|::..:....||||   :.|...:.       ||: |.|...||..
 Worm   184 ANFLLIVAINWD----ALNVNTLFMCSCLSL---FLHQGVIALVGVVADSNE-AGNRAEIARK-- 238

  Fly   227 IGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSS--- 288
                   :.||..:|..||..|.            .||:|||||:|.::|.::.:.:..|||
 Worm   239 -------LTEAVYRRTELETLKD------------RQEQLLLSVIPAYLADQVSKSIIQSSSTGS 284

  Fly   289 ---------------EAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRL 338
                           :.|..:::..|:|||||:||||.||.:::..:|:|||:.||||:::|||.
 Worm   285 TVEVPRTGKNNTKNHKLFHDLHVQVHDNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRD 349

  Fly   339 AEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGA 403
            |::.|.:|||.|||||||:||.|..||:||.:||.|||.|:..||.|:......|:||:|:|||:
 Worm   350 AQRLQCMRIKFLGDCYYCVSGMPVNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHTGS 414

  Fly   404 VLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAA---------FG 459
            ||.||:|.|:||||::|.||.|||.|||:|..|.|||:..|...|.|::.:..|         :|
 Worm   415 VLCGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLGDYCIVDANTDDPHVVSYG 479

  Fly   460 EKREELL--RIAGL-KTYFITKVVKAFASPCAKKINETQAEIAH-------PNPNGSTTDIVSDE 514
            :....:|  :.:.: :|..|.:..:...||..:.....:|:::.       ..|..:.|......
 Worm   480 QPTYHILPDKTSAIERTASIYRNSRLSTSPALQSRMSMKAKVSKMVEFWGAETPFANFTKKKFSA 544

  Fly   515 DDNDATLDDE-------------ELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTR 566
            ..:.|.:.||             ..|.:|:::|               ....|.......||.|.
 Worm   545 SHDPALITDEIARRPTYINTIPSMTLIENNLTN---------------FSFNNINSMFNCELPTI 594

  Fly   567 DGHENLTKDTNIFLRFKNPQLEQLYAVYREPYS-SLPLLAALLVQCIDVLYSYLVL-----PRST 625
            ..               :|:|  |:...|:..: :|.....|...||...::.|:|     |...
 Worm   595 PA---------------SPKL--LWPFSRKSITCNLSDCVLLTFVCIPSAFANLLLCSLYCPSDV 642

  Fly   626 LHFINIAA--PLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNV 688
            |..|::..  .::.:|||.::....|::|.|             ||.|..|.:..|  .||
 Worm   643 LQQISLQQFFTIIGLAMLSLLGRVCSYAGPL-------------ITMVAFLLSSCI--PIG---- 688

  Fly   689 IDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYP 753
                        .||:.:..             .:||::....|                 :..|
 Worm   689 ------------PHIIIKKS-------------KLEGVMAFNSL-----------------IFLP 711

  Fly   754 SYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYA 818
            |.:|                 ||..:.:|..:...|..|..|.         ||....::.:.:.
 Worm   712 SCVS-----------------HLVSVFILYRLPYSHRCFLFFA---------DFVIFQVLLSLFP 750

  Fly   819 ASGL----------LLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETA------------NDM 861
            |.|.          |.|.:::||.|...:...|     |.|....::|:|            ..|
 Worm   751 AYGAEVYVGYMGYHLSVVSISLSLLVVLLFFID-----WITNYERKRESACHVSFQNEERDVETM 810

  Fly   862 RQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLEC 926
            :..|:.|:.|:||..||..|: :..|:.::||::.:..|.|:|||:|||.||:||...|.: |||
 Worm   811 QDINKILIENILPSSVAAKFL-SPDRAVNELYARQHENVCVMFASIPNFKDFWSEWDTNRK-LEC 873

  Fly   927 LRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITE----------RW 981
            ||.|||::.:||.||..|:|..:.||||:|||||||:|:|......:|..:.:          |.
 Worm   874 LRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNIRH 938

  Fly   982 SHLA-----ILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNV 1041
            .::|     :::||||.:...|.::|..||.:|.|::|::.||:.||||||:||.|||||||||:
 Worm   939 GNMAFRNANLMIEFALAMSQILDALNRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNL 1003

  Fly  1042 ASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG-KGQLMTFYLQGKSQSSA 1098
            ||||::.|:...|..|.:...:|:..||....||.:.||| |..:.||.::..|:.::
 Worm  1004 ASRMDTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVKEPMETFLIEVDSKRNS 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	132/386 (34%)
		Guanylate_cyc	294..476	CDD:425528	89/193 (46%)
		Guanylate_cyc	892..1092	CDD:425528	93/215 (43%)
acy-2	NP_504553.1	Guanylate_cyc	307..486	CDD:425528	87/178 (49%)
		Guanylate_cyc	840..1054	CDD:425528	93/214 (43%)