Protein Alignment Ac3 and gcy-20

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_507101.1
• Gene: gcy-20 / 184797
• WormBaseID: WBGene00001545
• Length: 1108
• Species: Caenorhabditis elegans
• Alignment Length: 1277
• Identity: 236/1277 - (18%)
• Similarity: 411/1277 - (32%)
• Gaps: 482/1277 - (37%)

  Fly   167 ILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLY 231
            :|.|.||:... ||.|.:||.....|..:..|  |||         :.:|.|||:
 Worm     7 LLQNILVFCQF-LQTIKVGLMFSKDTASVIRS--VGY---------RTSAAAVLV---------- 49

  Fly   232 YFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYM 296
                          ||..:..:.::::...            :..||.  |..|.|..|.|.:.:
 Worm    50 --------------AKDRIRAEHLLDQYDF------------NFTIKF--DECSESLAAGKVVEL 86

  Fly   297 SRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAP 361
            ..|:||.:    |:|.|...:..:...|....|
 Worm    87 LTHDNVDV----IIGPTCNRAGVAVASLADFYN-------------------------------- 115

  Fly   362 DERPDHAVLCVHMGLSMVKAI----KYVQQKANSPVDMRVGIHT-GAVLAGILGQRQWQ--FDVY 419
                   |.....||:....|    :|     .:.|.:.:..|: ...:..||.|..|.  ..:|
 Worm   116 -------VPVFQWGLTTTADIGNFSRY-----QTTVTLSLDTHSISLAVREILRQYGWSEFVFIY 168

  Fly   420 SKD------VELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEK-REELLRIA-------- 469
            |.|      ..:.:.||..|    :..||.|:|::   .:::....|. :..||.::
 Worm   169 SNDGDEEKCAAMKDDMEKMG----IENSDVTMAYM---IQIQTVTMESLQRTLLEVSKRGRIIIA 226

  Fly   470 ------GLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDE-----DDNDATLDD 523
                  |.|..||...|.|..|     ..|.....|.|...|...|....:     ||.|..|
 Worm   227 CFASGRGFKKAFIASTVLAGMS-----TEEYLYVFAEPQSRGFYVDEADGKVHYSWDDTDGQL-- 284

  Fly   524 EELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGH-------ENLTKDTNIFLR 581
                              ||....||:               ||.:       :|:.:.|.|..:
 Worm   285 ------------------VTGLTNEQI---------------RDAYGKVLYICDNMGEPTTITTQ 316

  Fly   582 FKNPQLEQLYAVYREPYS--------SLPLLAALLVQCIDVLYSY-------------------- 618
            :.|...:.:..:..:|::        |....|....|..|..|:|
 Worm   317 YTNFTSQVISRMAEQPFNCVQDCSNQSYKHAATYAGQLADSFYAYAFALNKSLTQDPTRSNLKNG 381

  Fly   619 -LVLPRSTLHFINIAAPLVPI----AMLVVISLAESFSGMLP----KFFVDVS--------KRFN 666
             .||....:.|..:....|.:    :.:|.:.:....|.:||    ...|:||        |..:
 Worm   382 SFVLSNIGMTFQGVGGEAVTLDESGSRIVQVYMFAMNSSLLPYMAASLLVNVSEVVFTPFYKSES 446

  Fly   667 DITFVRELA----------------------------AIIIALTIGFSNVI-------------D 690
            ::..||.|:                            .:|:||..|.:.::             |
 Worm   447 ELWSVRPLSRPKCGFTGLECPADFVKEYLVYTIIAAFIVILALLAGCAGLLYTMHMKRKEMERQD 511

  Fly   691 MFFFVTFVRTEHIVSESEFNVTASLES-------DINLVVEGMVTAEHLLPASFVEQMRDAVPTE 748
            :.:.|.||..:.:.|:|  ...||:.|       ...:.||......:.:   |....::.|..:
 Worm   512 LLWQVAFVELQQVQSKS--RAEASMHSFASGPSTSTKMTVESRTETTNFI---FYHYHQEVVAAK 571

  Fly   749 R----VLYPS-------YLSNF---------GVLI----LIAIAVIAQLTHLTKILLLLSIAALH 789
            :    ||:.:       .:.||         |:.:    |:::........|:.::...|: .:.
 Worm   572 KHDLLVLFDANQKSEFRQMRNFDNDNLNKFIGLCLDGPQLLSLWRFCSRGSLSDVISKSSM-QMD 635

  Fly   790 CYFNIFIMQDL------------------------------------------------------ 800
            .:|...:::|:
 Worm   636 SFFMFSLIRDISNGLYFIHSSFLKCHGQLTSRCCLIDDRWQIKISGFGLKSVRTFENPKKEDLLW 700

  Fly   801 ----YALEDDFEHQP------------IISTRYAA------------------------------ 819
                |...:|.|..|            .|.||.:|
 Worm   701 ASPEYLRNEDQERLPEGDIYSFGIICAEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPTRPSLD 765

  Fly   820 SGLLLVAALALSTLARH------------------------------MDHEDRVIFKW----KTE 850
            :|..:|...||..|.|.                              |||...::..:    :.|
 Worm   766 TGETVVINPALLHLVRDCWTERPSERPSIEQVRSHLNGMKDGRKTNLMDHVFNMLETYASTLEEE 830

  Fly   851 VAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYS 915
            |:::.:...:.:::::.|:|.:||..||:..     :....:..:::.:|.:.|:.:..|:....
 Worm   831 VSDRTKELTEEKKKSDVLLYRMLPRMVADKL-----KLGQTVEPETFEQVTIFFSDVVQFTTLAG 890

  Fly   916 EETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITER 980
            :.|    .|:.:..||::.:.||.::|.   .|:.|::|||..|:..||:          |....
 Worm   891 KCT----PLQVVTLLNDLYTIFDGIIEQ---NDVYKVETIGDGYLCVSGL----------PHRNG 938

  Fly   981 WSHLAILVEFALELKHALQSINEQSF--NHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVAS 1043
            ..|:..:...:|....:|:....|..  ....|::|||.|.:.|||:|...|.|.::|:.||.||
 Worm   939 NDHIRHIARMSLGFLSSLEFFRVQHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTAS 1003

  Fly  1044 RMESTGKAGAIQVTEETCNILR--LFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVV 1106
            ||||.||.|.|.||.|...:|.  :.|:....||.|.:||||.:.||:|.|:......|..:...
 Worm  1004 RMESNGKPGQIHVTAEANRMLTQVVGGFRTESRGEVIIKGKGVMETFWLLGEESGYTAPSKAAPK 1068

  Fly  1107 VLNGQDSSAVESTSELEASDIKMPLLKMN--GPE-QSLEIDQ 1145
            |:  |...::.|.|         |:|:.|  |.| .||.:||
 Worm  1069 VI--QHRQSIRSIS---------PILEKNAEGSETSSLSVDQ 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	56/300 (19%)
		Guanylate_cyc	294..476	CDD:425528	34/209 (16%)
		Guanylate_cyc	892..1092	CDD:425528	62/203 (31%)
gcy-20	NP_507101.1	PBP1_NPR_GC-like	22..427	CDD:380575	93/548 (17%)
		Protein Kinases, catalytic domain	536..801	CDD:473864	29/268 (11%)
		HNOBA	<817..861	CDD:462234	8/43 (19%)
		CYCc	840..1032	CDD:214485	58/213 (27%)