Protein Alignment Ac3 and gcy-11

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001359843.1
• Gene: gcy-11 / 181745
• WormBaseID: WBGene00001537
• Length: 1168
• Species: Caenorhabditis elegans
• Alignment Length: 797
• Identity: 173/797 - (21%)
• Similarity: 293/797 - (36%)
• Gaps: 257/797 - (32%)

  Fly   360 APDERPDHAVLCVH-MGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDV 423
            |.:.|.:.:...|| ..:.:|...|:...:..|.:...:.:.:....:|.:|.....|  |:..:
 Worm   543 AYERRLESSYFLVHRKHVQLVDMTKFGSSRGGSMIQSAMSMRSQYEDSGPVGGATMNF--YTNGI 605

  Fly   424 ELA----NKMESSGK---AGR--------------------VHISDKTLAFLNGEF--EVEAAFG 459
            ..|    |:|:.|.|   |.|                    |...:||...|..|.  |::....
 Worm   606 RKAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAKYENTLVTVRKINKTQLKLTREMKQEIDLLMN 670

  Fly   460 EKREELLRIAGLKTYFITKVVKAFASPCAKKINETQA--EIAHPNPNGSTTDIVSDEDDNDATLD 522
            |..|.|.|..||                   |||:..  .|....|..|..|::.::   |..||
 Worm   671 ETHENLNRFFGL-------------------INESDLIFTIHSYGPRKSLMDLLRND---DLRLD 713

  Fly   523 --------DEELLAQNSVSNGHQIGI-------AVTADEEEQVKLENFKQRLKDELVTRDGHENL 572
                    ::.:.....:..|.:||.       ....|...::||.|:..    |.:..:..|:.
 Worm   714 RMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGM----EQIRVEEPESK 774

  Fly   573 TKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVP 637
            ..|    |.:..|::.:.||| :...|.|.|..|.:.....|||
 Worm   775 PDD----LLWFAPEIIRRYAV-KHDLSKLELAKADIYSLAIVLY--------------------- 813

  Fly   638 IAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEH 702
                      |.:....|         |.|                   :::|         ::.
 Worm   814 ----------EIYGRQGP---------FGD-------------------DLLD---------SDE 831

  Fly   703 IVSESEFNVTASL-ESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIA 766
            |:.:.:|....:| ..||:|:.:    |.:.| ||.||:.....|..|   ||
 Worm   832 IIEQLKFPDGGALTRPDIHLITK----APYPL-ASVVEKCWVEDPASR---PS------------ 876

  Fly   767 IAVIAQLTHLTKIL---LLLSIAALHCYFNIFIMQDLYA--LEDDFEHQPIISTRYAASGLLLVA 826
               |.::..|.|.|   |..:||.     ||..:.|.|.  |||
 Worm   877 ---IKKVRELLKPLSKGLKGNIAD-----NIMNLLDRYRNNLED--------------------- 912

  Fly   827 ALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDD 891
                             :.|.:||..|      |.|:|||:|:..:||..||     |:.::...
 Worm   913 -----------------VIKERTEQLE------DERKRNESLLLQLLPKSVA-----NSLKNGQP 949

  Fly   892 LYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIG 956
            :.::.|..|.:.|:.:..|:...|:.|    .|:.:..||.:.::||.:::  :| |..|::|||
 Worm   950 VDAEFYDSVSIYFSDIVGFTALSSKST----PLQVVNMLNNLYTNFDTIID--KF-DCYKVETIG 1007

  Fly   957 STYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNH-----FVLKMGIN 1016
            ..||..||:          |....:.|...:...:|||   |.||...:.:|     ..|::|.:
 Worm  1008 DAYMFVSGL----------PEVNSYLHAGEVASASLEL---LDSIKTFTVSHCPDEKLRLRIGNH 1059

  Fly  1017 HGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCN-ILRLFGYTFLQRGLVAVK 1080
            .||:..||:|.|.|.|.::|:||.:|:.|||:|:...||::.:... ||:..||...||..:.:|
 Worm  1060 TGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDAYELILKCGGYVTEQREKIVLK 1124

  Fly  1081 GKGQLMTFYLQGKSQSS 1097
            .|.::||:::...|:.:
 Worm  1125 NKLEVMTYWMNDYSKDA 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485	23/122 (19%)
		Guanylate_cyc	294..476	CDD:278633	30/145 (21%)
		CYCc	860..1071	CDD:214485	65/216 (30%)
		Guanylate_cyc	892..1092	CDD:278633	60/205 (29%)
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743	69/371 (19%)
		CYCc	923..1116	CDD:214485	65/217 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810