DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and Npr3

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_032754.2	Gene:	Npr3 / 18162	MGIID:	97373	Length:	536	Species:	Mus musculus

Alignment Length:	513	Identity:	102/513 - (19%)
Similarity:	181/513 - (35%)	Gaps:	144/513 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 VEGMVTAEHLLPASFVEQMR---------------DAVPTERVLYPSYLSNFGVLILIAIAVIAQ 772
            |||..|...|||.....|:.               |.|...|...|..:  .|.:...|.|.:|:
Mouse    78 VEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLI--LGPVCEYAAAPVAR 140

  Fly   773 L-THLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARH 836
            | :|..  |.:||..||...|.        ..:.::.|...::..||..|.:::|      |.||
Mouse   141 LASHWD--LPMLSAGALAAGFQ--------HKDTEYSHLTRVAPAYAKMGEMMLA------LFRH 189

  Fly   837 MDHEDRVIFKWKTEVAEQKETANDMRQRN-----EAL--VYNVLPVHVAEHFMKNTK-RSHDDL- 892
             .|..|....:          ::|..:||     |.:  |:....:|.:.:....|| ...||:
Mouse   190 -HHWSRAALVY----------SDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIV 243

  Fly   893 -YSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIG 956
             |.|....|.::.|         |.:|:....|...|  :.:.|...|...:..|.        .
Mouse   244 RYIQGSERVVIMCA---------SGDTIRRIMLAVHR--HGMTSGDYAFFNIELFN--------S 289

  Fly   957 STYMAASGINVQRTVRNDAPITERWSHLAILV----------EFALELKHAL--QSINEQSF-NH 1008
            |:|...|.   :|..::|:...:.:|.|..:.          :|::|:|.::  |.:||:.: |.
Mouse   290 SSYGDGSW---RRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNM 351

  Fly  1009 FV--------LKMGINHGPITAGVIGARKPHYDI----WGNT-------VNVASRMESTGKAGAI 1054
            ||        |.:...|..:.||.  ::|....|    |..|       |::.:..:..|....:
Mouse   352 FVEGFHDAILLYVLALHEVLRAGY--SKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVV 414

  Fly  1055 QVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVEST 1119
            .:|:.......:.|..|.:.|...::...:    |..|..:...:...    ::...:||..:|:
Mouse   415 AMTDTEAGTQEVIGDYFGKEGRFQMRSNVK----YPWGPLKLRLDETR----IVEHTNSSPCKSS 471

  Fly  1120 SELEASDI------------------------KMPLLKMNGPEQSLEIDQDRSLRNDS 1153
            ..||.|.:                        ::.:.:.|..|:| .|.:.|.||.||
Mouse   472 GGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEES-NIGKHRELREDS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		CYCc	860..1071	CDD:214485	49/252 (19%)
		Guanylate_cyc	892..1092	CDD:278633	42/233 (18%)
Npr3	NP_032754.2	PBP1_NPR_C_like	49..440	CDD:107381	85/414 (21%)
		ANF_receptor	66..419	CDD:279440	82/393 (21%)
		TM_EphA1	471..502	CDD:214014	3/30 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900