Protein Alignment Ac3 and odr-1

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001362115.1
• Gene: odr-1 / 181479
• WormBaseID: WBGene00003848
• Length: 1047
• Species: Caenorhabditis elegans
• Alignment Length: 1123
• Identity: 223/1123 - (19%)
• Similarity: 395/1123 - (35%)
• Gaps: 349/1123 - (31%)

  Fly   203 YSHWDSLLSNQLAANAVLIATA--------ALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQ 259
            :.:|.|  :..:.|:||..|||        ..|...:...|:...|.|      |..:..|....
 Worm    26 FDNWPS--AQNVCASAVADATANGQCTTKSIQINQQHGCSGDNSVKSA------SYAINAVASRT 82

  Fly   260 SAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDL 324
            |.|.:.:.       |......|:.:...  |.:|:.|          .::|:..:......|:|
 Worm    83 SGELDFVF-------VGPTCTTDIRTIGD--FAEIWKS----------PVIGYEPVFEARGVQEL 128

  Fly   325 VKMLNELFARFD---------RLAEKYQQLRIKILGDCYYCISG---APDERPDHAVLCVHMGLS 377
            ..::|  .|:|.         .|.::.:|:.|.::|......:|   :.|.|..:.:      ::
 Worm   129 TSVIN--VAQFSVGGVAETLVFLMKELEQVEITLVGSVKVLPNGLSLSNDLRSYNEI------MN 185

  Fly   378 MVKAIKYVQQKAN----SPVDMRV--GIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAG 436
            ..|..:||:...|    :.||.::  |.....|.|..       :|:||....:..:..|..:..
 Worm   186 SFKIREYVEVDENDVDWTKVDQKIKRGARMIVVCADF-------YDIYSAFYNIGIRSLSGFRFI 243

  Fly   437 RVHISD------------KTLAFLNGEF-------EVEAAFGEKREELLRIAGLKTYFITKVVKA 482
            .|.|.:            |.|.:.:..|       :...||...::.:..:|..:.....::..|
 Worm   244 IVVILNKPPDEILNQPNVKNLLYGSNAFIISPLQEQYSDAFSIMQDVIPNLADDQFTTFLRIYHA 308

  Fly   483 FASPCAKKIN--ETQAEIAHPNPNGS--TTDIVSDEDDND--------------ATLDDEELLAQ 529
            ..:.|...:|  |||.:..|...:|.  ||...:...||.              |.:..|.:|..
 Worm   309 CYAYCVGSVNGAETQTDNYHTAMSGKAVTTKYGTFTFDNSGSVLTNYAVFTINPAEMTFESILTL 373

  Fly   530 NSVS------NGHQIGIAVTAD------------------------------------------- 545
            .||:      |..|:....|:|
 Worm   374 KSVAKSCDTYNCFQLSPNKTSDLLWTLKDMDPPDDCVAKSSCVNYIPHIIAAVVIVTIIVIAIVI 438

  Fly   546 ------------------EEEQVKL---ENFKQRLKDELVTR----DGHENLTKDTNIF------ 579
                              .:|.:|:   :|...:::.||..|    |....||....:|
 Worm   439 IVKQRRHKLNIYKLTWKVPKESLKIIVNKNADAKMQRELENRASNTDNAAALTSRRRVFGSYALV 503

  Fly   580 --LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTL-HFINIAAPLVPIAML 641
              .|.:..|.:|:..: ..|.::|           |.|||...|....| .|..|......:.|.
 Worm   504 GTQRAEYVQFKQIRKI-NFPETTL-----------DYLYSLKQLQHDNLAKFYGIQVNDDIMTMT 556

  Fly   642 VVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSE 706
            ::.:|.|  .|.|.:|.:|           |:         .|..:.....|....::....:.:
 Worm   557 ILHTLVE--RGTLEEFCLD-----------RD---------FGMDDTFKSAFMRDILKGLQYLHK 599

  Fly   707 SEFNVTASLES-----DINLVVE----GMVTAEHLLPASFVEQMRDA----VPTE---RVLYPSY 755
            |.......|::     |||.|::    |:        ::|:....||    ||.:   .:.||.|
 Worm   600 SSIGYHGHLQASTCLIDINWVLKLTLYGV--------SNFMSDQLDAENIKVPEQAAHMITYPQY 656

  Fly   756 LSNFGVLILIAIAVIAQLTHL----------TKILLLLSIAALHCYFNIFIM----QDLYALEDD 806
                         |.....|:          .:::.......::|...||.|    :|.|.|...
 Worm   657 -------------VCFPPEHIREYDDSGKQPPRVVRGSPKGDIYCVGMIFYMMVEREDPYHLIHS 708

  Fly   807 FE--------------HQPIISTRYAASGLLL----------------VAAL--ALSTL-----A 834
            .|              |.|.|:..|....:||                :..|  ::||:     .
 Worm   709 VERPNATLIKQILNENHMPRITDDYRQENMLLEMCKECWDRNPDKRPTIKKLIESISTVYPLSKG 773

  Fly   835 RHMDHEDRVIFKWKTEVAEQK--ETAN--DMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQ 895
            ..:|...|:..|:..|:.:..  .||:  |.:.:...|:..:||..:|:. :||..    .:..:
 Worm   774 NLVDQMIRMSEKYADELEQMVAIRTADLADAQMQTMRLLNEMLPASIAKD-LKNGL----IMPPR 833

  Fly   896 SYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYM 960
            ||....|:|..:.:|:......:..    :.:.|||::...||.:::.   .|..|::|.|.|||
 Worm   834 SYESATVMFVQICDFNALMKRSSPE----QVIAFLNDIYDQFDTVIKR---HDAYKVETTGETYM 891

  Fly   961 AASGINVQRTVRNDAPITERWSHLAILVEFALELK-----HALQSINEQSFNHFVLKMGINHGPI 1020
            .|||:          |......|:..:.|.:||::     :.||  :::::. ..:::|.:.|||
 Worm   892 VASGV----------PHENEGRHIFEVAEISLEIREISYIYVLQ--HDKNYK-LRIRIGFHAGPI 943

  Fly  1021 TAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFG---YTFLQRGLVAVKGK 1082
            .|||||.|.|.|.::|:|||.||||:|......||.:|.|..:  ||.   |.|::||:|.||||
 Worm   944 AAGVIGIRSPRYCLFGDTVNFASRMQSNCPPNQIQTSEITARL--LFDSHEYKFVKRGIVHVKGK 1006

  Fly  1083 GQLMTFYLQGKSQSSAEP 1100
            |::..::|........||
 Worm  1007 GEVNCYWLNEHLHEETEP 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	52/296 (18%)
		Guanylate_cyc	294..476	CDD:425528	36/218 (17%)
		Guanylate_cyc	892..1092	CDD:425528	65/207 (31%)
odr-1	NP_001362115.1	Periplasmic_Binding_Protein_type1	63..378	CDD:471960	63/354 (18%)
		PK_GC	495..768	CDD:270894	58/327 (18%)
		CYCc	803..996	CDD:214485	62/219 (28%)